Effect of the type of hydrophobic polymers on the size of nanoparticles obtained by emulsification–solvent evaporation

Chernysheva, Yulia V.; Babak, Valéry G.; Кильдеева, Н. Р.; Boury, Frank; Benoit, J.; Ubrich, Nathalie; Maincent, Philippe

doi:10.1070/mc2003v013n02abeh001690

Cited by 41 publications

(24 citation statements)

References 7 publications

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“…The best known class of biodegradable materials for controlled release is poly (lactic acid-co-glycolic acid) (PLGA). 7 Many publications have described preparation of nanoparticles using PLGA and studied formulation variables, including the molecular weight of PLGA, 8 lyophilizing agents, 9 and surfactants. 10 Therefore, we investigated a sustained injection formulation of docetaxel prepared using PLGA by the solvent-evaporation method.…”

Section: Introductionmentioning

confidence: 99%

Practical preparation procedures for docetaxel-loaded nanoparticles using polylactic acid-co-glycolic acid

Cho¹,

Keum²,

Noh³

et al. 2011

IJN

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Background Nanoparticles fabricated from the biodegradable and biocompatible polymer, polylactic-co-glycolic acid (PLGA), are the most intensively investigated polymers for drug delivery systems. The objective of this study was to explore fully the development of a PLGA nanoparticle drug delivery system for alternative preparation of a commercial formulation. In our nanoparticle fabrication, our purpose was to compare various preparation parameters. Methods Docetaxel-loaded PLGA nanoparticles were prepared by a single emulsion technique and solvent evaporation. The nanoparticles were characterized by various techniques, including scanning electron microscopy for surface morphology, dynamic light scattering for size and zeta potential, x-ray photoelectron spectroscopy for surface chemistry, and high-performance liquid chromatography for in vitro drug release kinetics. To obtain a smaller particle, 0.2% polyvinyl alcohol, 0.03% D-α-tocopheryl polyethylene glycol 1000 succinate (TPGS), 2% Poloxamer 188, a five-minute sonication time, 130 W sonication power, evaporation with magnetic stirring, and centrifugation at 8000 rpm were selected. To increase encapsulation efficiency in the nanoparticles, certain factors were varied, ie, 2–5 minutes of sonication time, 70–130 W sonication power, and 5–25 mg drug loading. Results A five-minute sonication time, 130 W sonication power, and a 10 mg drug loading amount were selected. Under these conditions, the nanoparticles reached over 90% encapsulation efficiency. Release kinetics showed that 20.83%, 40.07%, and 51.5% of the docetaxel was released in 28 days from nanoparticles containing Poloxamer 188, TPGS, or polyvinyl alcohol, respectively. TPGS and Poloxamer 188 had slower release kinetics than polyvinyl alcohol. It was predicted that there was residual drug remaining on the surface from x-ray photoelectron spectroscopy. Conclusion Our research shows that the choice of surfactant is important for controlled release of docetaxel.

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Section: Introductionmentioning

confidence: 99%

Practical preparation procedures for docetaxel-loaded nanoparticles using polylactic acid-co-glycolic acid

Cho¹,

Keum²,

Noh³

et al. 2011

IJN

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“…As a result, the preparation of Eudragit RL pseudolatex using chloroform as a solvent was not possible and led to a massive aggregation of particles (Table 2). Saito et al 13 and recently Chernysheva et al 14 have confirmed that lowering the interfacial tension is effective for increasing the o/w emulsion stability.…”

Section: Role Of the Interfacial Tensionmentioning

confidence: 72%

Preparation of surfactant-free nanoparticles of methacrylic acid copolymers used for film coating

et al. 2006

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The aim of the present study was to prepare surfactant-free pseudolatexes of various methacrylic acid copolymers. These aqueous colloidal dispersions of polymeric materials for oral administration are intended for film coating of solid dosage forms or for direct manufacturing of nanoparticles. Nanoparticulate dispersions were produced by an emulsificationdiffusion method involving the use of partially water-miscible solvents and the mutual saturation of the aqueous and organic phases prior to the emulsification in order to reduce the initial thermodynamic instability of the emulsion. Because of the self-emulsifying properties of the methacrylic acid copolymers, it was possible to prepare aqueous dispersions of colloidal size containing up to 30% wt/vol of Eudragit RL, RS, and E using 2-butanone or methyl acetate as partially watermiscible solvents, but without any surfactant. However, in the case of the cationic Eudragit E, protonation of the tertiary amine groups by acidification of the aqueous phase was necessary to improve the emulsion stability in the absence of surfactant and subsequently to prevent droplet coalescence during evaporation. In addition, a pseudolatex of Eudragit E was used to validate the coating properties of the formulation for solid dosage forms. Film-coated tablets of quinidine sulfate showed a transparent glossy continuous film that was firmly attached to the tablet. The dissolution profile of quinidine sulfate from the tablets coated with the Eudragit E pseudolatex was comparable to that of tablets coated with an acetonic solution of Eudragit E. Furthermore, both types of coating ensured similar taste masking. The emulsificationevaporation method used was shown to be appropriate for the preparation of surfactant-free colloidal dispersions of the 3 types of preformed methacrylic acid copolymers; the dispersions can subsequently be used for film coating of solid dosage forms.

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“…Due to their quaternary ammonium groups, Eudragit  RS has surface active properties able to stabilize the first emulsion, and consequently hampers the coalescence of the droplets, leading to minimize the diameter of the particles (Chernysheva et al, 2003). Since the particle size is related to a great extent to the stability of the first emulsion, it can be assumed that some excipients included in the commercial presentation of Novorapid  could interfere with Eudragit  RS.…”

Section: Discussionmentioning

confidence: 99%

Influence of polymers ratio on insulin-loaded nanoparticles based on poly-ε-caprolactone and Eudragit^®RS for oral administration

Socha¹,

Sapin²,

Damgé³

et al. 2009

Drug Delivery

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Effect of the type of hydrophobic polymers on the size of nanoparticles obtained by emulsification–solvent evaporation

Cited by 41 publications

References 7 publications

Practical preparation procedures for docetaxel-loaded nanoparticles using polylactic acid-co-glycolic acid

Practical preparation procedures for docetaxel-loaded nanoparticles using polylactic acid-co-glycolic acid

Preparation of surfactant-free nanoparticles of methacrylic acid copolymers used for film coating

Influence of polymers ratio on insulin-loaded nanoparticles based on poly-ε-caprolactone and Eudragit^®RS for oral administration

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Effect of the type of hydrophobic polymers on the size of nanoparticles obtained by emulsification–solvent evaporation

Cited by 41 publications

References 7 publications

Practical preparation procedures for docetaxel-loaded nanoparticles using polylactic acid-co-glycolic acid

Practical preparation procedures for docetaxel-loaded nanoparticles using polylactic acid-co-glycolic acid

Preparation of surfactant-free nanoparticles of methacrylic acid copolymers used for film coating

Influence of polymers ratio on insulin-loaded nanoparticles based on poly-ε-caprolactone and Eudragit®RS for oral administration

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Product

Resources

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Influence of polymers ratio on insulin-loaded nanoparticles based on poly-ε-caprolactone and Eudragit^®RS for oral administration