Effect of the triterpene 3β, 6β, 16β-trihydroxylup-20(29)-ene isolated from the leaves of Combretum leprosum Mart. on cutaneous wounds in mice

Neto, Luiz Gonzaga do Nascimento; Evaristo, Francisco Flávio Vasconcelos; Alves, Mayara Freire de Alencar; Albuquerque, Maria Rose Jane R.; Santos, Hélcio Silva dos; Bandeira, Paulo Nogueira; Arruda, Francisco Vassiliepe Sousa; Teixeira, Edson Holanda

doi:10.1016/j.jep.2015.05.037

Cited by 16 publications

(10 citation statements)

References 33 publications

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“…Thus, M. hirsuta fraction, enriched in pentacyclic triterpenes, might be a promising potential source for the development of new wound dressings. In fact, studies have already reported beneficial effects of triterpenes on wound healing by inducing basal cell proliferation, keratinocyte differentiation and stimulating angiogenesis, and collagen production by fibroblasts [33,34]. These findings provided the basis for the formulation of CMHF.…”

Section: Chemical Composition Of Mhfmentioning

confidence: 88%

Chitosan Film Containing Mansoa hirsuta Fraction for Wound Healing

et al. 2020

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Chitosan films entrapped with the Mansoa hirsuta fraction (CMHF) was developed as a new dressing for wound care. The chromatographic profile of the M. hirsuta fraction (MHF) was evaluated by ultra-high-performance liquid chromatography-quadrupole time-of-flight mass spectrometry, and the results showed that MHF is rich in acid triterpenes. Physicochemical characterization of the films prepared using the solvent casting method was performed by Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), thermogravimetry (TGA), differential scanning calorimetry (DCS), scanning electron microscopy (SEM), atomic force microscopy (AFM), and mechanical properties. CMHF exhibited characteristic bands of both chitosan and MHF, revealing a physical mixture of both. CMHF presented an amorphous nature, thermostability, and dispersion of MHF in the chitosan matrix, resulting in a rough structure. Incorporation of M. hirsuta fraction into chitosan matrix favorably enhanced the mechanical performance and films thickness. The in vivo wound treatment with CMHF for seven days showed a characteristic area of advanced healing, re-epithelization, cell proliferation, and collagen formation. Furthermore, wound closure reached 100% contraction after 10 days of treatment with modulation of interleukins. The incorporation of M. hirsuta fraction into chitosan films was advantageous and showed great potential for stimulating wound repair and regeneration.

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Section: Chemical Composition Of Mhfmentioning

confidence: 88%

Chitosan Film Containing Mansoa hirsuta Fraction for Wound Healing

et al. 2020

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“…Nascimento-Neto et al [34] provided evidence of the role of C. leprosum on wound healing. Treatment with CLF-1 improved the formation of new blood vessels, structuring the extracellular matrix for migration of keratinocytes and increasing tensile strength of the injury, thus leading to a faster and more effective closure.…”

Section: Healing Activitymentioning

confidence: 99%

“…Among the bioactive triterpenes isolated from plants, the pentacyclic triterpene of the lupine class 3β, 6β, 16β-trihydroxilup-20(29)-eno (C 30 H 50 O 3 , hereafter named CLF-1) (Figures 3 and 4) can be highlighted. It is isolated from C. leprosum which has received attention due to its great pharmacological importance, evidenced by its antioxidant, anti-inflammatory, antiviral, antitumoral, antiparasitic, antinociceptive, healing, and antibacterial properties [32][33][34].…”

Section: Ethnopharmacology and Phytochemical Studymentioning

confidence: 99%

Pharmacological potential of the triterpene 3β,6β,16β‐trihidroxilup‐20 (29)‐ene isolated from Combretum leprosum: A literature review

Coutinho

Oliveira

Evaristo

et al. 2022

Fundamemntal Clinical Pharma

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Globally, plant‐derived medicines have been playing an increasing and relevant role in the treatment of several diseases, thus fostering the search for new bioactive substances. Among the various families of plants studied, those of the Combretum genus can be highlighted since they are widely used in folk medicine for the treatment of hepatitis, malaria, respiratory infections, cancer, skin hemorrhage, and anxiety. Phytochemical studies carried out on species of the Combretum genus demonstrated the presence of several classes of bioactive chemical compounds, including the triterpene 3β,6β,16β‐trihydroxilup‐20(29)‐ene (CLF‐1). In this perspective, the objective of this review was to gather all pharmacological activities attributed to the CLF‐1 triterpene, highlighting its importance for the pharmaceutical industry. The research was performed in scientific databases such as PubMed, SciELO, LILACS, SciFinder and Science Direct. The literature indicates a great pharmacological potential of CLF‐1, evidencing its antioxidant, anti‐inflammatory, antiviral, antiparasitic, antinociceptive, healing, and antibacterial action, antinociceptive and antitumor effect. Therefore, based on the different research above, it is plausible to consider CLF‐1, obtained from different parts of the C. leprosum plant, as a molecule with biotechnological potential that may contribute to the development of new drugs and, consequently, in the treatment of various human pathologies.

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“…In addition, the healing action is a complex process involving biochemical mediator aiming to restore the tissue integrity and functionality through cell proliferation and activation of extracellular matrix components (Nascimento-Neto et al, 2015;Silva et al, 2010b). The regeneration process can be interfered by the health status of the patient, nutrition, age, and place of injury, hampering the natural healing process (Choudhary et al, 2020;Moeini et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Anti-inflammatory and wound healing properties from Caatinga plant species: how they do it? – A literature review

Miranda

Fernandes

Silva

et al. 2022

RSD

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Being one of the phytogeographic domains exclusively present in Brazil, the Caatinga occupies approximately 11% of the Brazilian territory and is one of the drylands with the most diversity around the world. The Caatinga is home to a floristic variety that carries a plurality of bioactive compounds capable of reversing physiological disorders. Many bioactive products from Caatinga species have anti-inflammatory and healing potential. The present review aimed to summarize the works that explored the anti-inflammatory and healing activities of plant species present in this phytogeographic domain. The articles were selected from the databases: Elsevier, Springer links, and PubMed to build the present review. In total, 39 plant species were identified, which were studied about their biological potential with experimental assays, and we’ve discussed how its compounds are related to the anti-inflammatory and healing activities. Our results highlight that the most studied product obtained from those plant species is the plant extract, and still those studies aren’t clear about its phytochemical profile. On the other hand, the research focused on plant oils provides a better understanding of how Caatinga plant species promote anti-inflammatory and wound healing action.

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Effect of the triterpene 3β, 6β, 16β-trihydroxylup-20(29)-ene isolated from the leaves of Combretum leprosum Mart. on cutaneous wounds in mice

Cited by 16 publications

References 33 publications

Chitosan Film Containing Mansoa hirsuta Fraction for Wound Healing

Chitosan Film Containing Mansoa hirsuta Fraction for Wound Healing

Pharmacological potential of the triterpene 3β,6β,16β‐trihidroxilup‐20 (29)‐ene isolated from Combretum leprosum: A literature review

Anti-inflammatory and wound healing properties from Caatinga plant species: how they do it? – A literature review

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