Effect of the topical application of an ethanol extract of quince seeds on the development of atopic dermatitis-like symptoms in NC/Nga mice

Abstract

BackgroundQuince (Cydonia oblonga Miller) is a deciduous shrub belonging to the Rosaceae family. Quince seed extract has long been used as a cosmetic ingredient for its moisturizing effect. However, little is known about whether quince seed extract has therapeutic effects on keratinocyte-associated skin inflammation.MethodsIn the present study, we investigated the effect of the topical application of ethanol extract of quince seeds (QSEtE) on atopic dermatitis (AD) symptoms in NC/Nga mice. The direct effect of QSEtE on keratinocytes was evaluated using the human keratinocyte cell line HaCaT.ResultsThe preliminary application of QSEtE markedly reduced house dust mite allergen-induced skin lesions. The expression of thymus- and activation-regulated chemokine (TARC) in dorsal skin was downregulated. QSEtE directly suppressed the expression and production of TARC in HaCaT cells.ConclusionsThe results suggest that the topical application of QSEtE is effective in preventing the onset of and ameliorating the atopic symptoms of keratinocyte-associated skin inflammation by suppressing TARC production in keratinocytes.

The Renaissance of Plant Mucilage in Health Promotion and Industrial Applications: A Review

“…Mucilages (from quince and aloe) are used as moisturizers in creams, lotions, and soaps. Their water-holding ability together with moisturizing and antimicrobial properties make mucilages suitable for the production of dressings for wounds and skin burns, as well as to treat inflammation [1,75].…”

“…Quince seed mucilage has been reported to have important pharmaceutical, medicinal, and cosmetic applications. It is used to heal wounds and treat inflammatory skin conditions (e.g., atopic dermatitis) as well as protect against skin toxicity caused by the T-2 toxin [75].…”

Inhibitory Effects of Urtica thunbergiana Ethanol Extract on Atopic Dermatitis-Induced NC/Nga Mice

“…Streptozotocin-induced diabetes 29749986 [35] * PMID: PubMed Identifier; ** DOI: Digital Object Identifier. [46] Anti-viral 28393840 [47] PMID: The PubMed IDentifier is a unique number assigned to each Pubmed record. The structures were downloaded from pubchem.…”

The Fatty Acid Composition and Quality of Oils from Post‐Industrial Waste of Quince Chaenomeles japonica

“…Studies have shown that incorporating oregano or thyme essential oils into quince seed mucilage film is a natural antibacterial agent that could be used for food safety . Studies to date have shown that EtEQS (ethanol extract of quince seeds) appears to be promising in protecting the skin from allergen‐induced Th2‐type inflammation and reduces the effects of atopic dermatitis …”

“…[10] Studies to date have shown that EtEQS (ethanol extract of quince seeds) appears to be promising in protecting the skin from allergen-induced Th2-type inflammation and reduces the effects of atopic dermatitis. [11] Cold-pressed quince seed oil is one of the products that can be used in food, as well as in skincare products and in the pharmaceutical industry. [12] However, no studies have yet been carried out to prove that the quince seeds after industrial processing are suitable for oil production.…”