Effect of the surface chemistry on the stability and mechanical properties of the Zirconia-Hydroxyapatite bioceramic

Es-saddik, M.; Laasri, Said; Taha, Mohammed A.; Laghzizil, A.; Guidara, Awatef; Chaari, Kamel; Bouaziz, Jamel; Hajjaji, A.; Nunzi, Jean‐Michel

doi:10.1016/j.surfin.2021.100980

Cited by 7 publications

(2 citation statements)

References 25 publications

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“…Fluorescence-conjugated nanomaterials developed as multifunctional platforms are powerful in cancer diagnosis and therapy, which attracts significant attention nowadays. − These nanoparticles (NPs) could be divided into several types: fluorescent dye-doped NPs, , semiconductor quantum dots, , metal nanoclusters, , rare-earth NPs, , and fluorescent carbon-based nanomaterials. , Generally, NPs are synthesized from a host system and doping material to exploit the advantages of both elements . Among nanomaterial hosts, hydroxyapatite (HAp), which possesses a unique hexagonal structure and actively replaceable Ca 2+ units, has been investigated in several studies. , Accordingly, numerous studies have revealed that several free ions, such as monovalent Na + ; divalent Zn 2+ , Cu 2+ , and Mg 2+ ; − trivalent Au 3+ and Ag 3+ ; , tetravalent Ti 4+ and Zr 4+ , − can be replaced with the Ca 2+ ions of HAp, indicating the host potential of doped HAp in biomedical applications.…”

Section: Introductionmentioning

confidence: 99%

Yb–Gd Codoped Hydroxyapatite as a Potential Contrast Agent for Tumor-Targeted Biomedical Applications

Doan

et al. 2023

ACS Biomater. Sci. Eng.

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Recently, various nanomaterials based on hydroxyapatite (HAp) have been developed for bioimaging applications. In particular, HAp doped with rare-earth elements has attracted significant attention, owing to its enhanced bioactivity and imaging properties. In this study, the wet precipitation method was used to synthesize HAp codoped with Yb and Gd. The synthesized Yb x -Gd x -HAp nanoparticles (NPs) were characterized via various techniques to analyze the crystal phase, functional groups, thermal characteristics, and particularly, the larger surface area. The IR783 fluorescence dye and a folic acid (FA) receptor were conjugated with the synthesized Yb x -Gd x -HAp NPs to develop an effective imaging contrast agent. The developed FA/IR783/Yb-Gd-HAp nanomaterial exhibited improved contrast, sensitivity, and tumor-specific properties, as demonstrated by using the customized LUX 4.0 fluorescence imaging system. An in vitro cytotoxicity study was performed to verify the biocompatibility of the synthesized NPs using MTT assay and fluorescence staining. Photodynamic therapy (PDT) was also applied to determine the photosensitizer properties of the synthesized Yb x -Gd x -HAp NPs. Further, reactive oxygen species generation was confirmed by Prussian blue decay and a 2′,7′-dichlorofluorescin diacetate study. Moreover, MDA-MB-231 breast cancer cells were used to evaluate the efficiency of Yb x -Gd x -HAp NP-supported PDT.

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Section: Introductionmentioning

confidence: 99%

Yb–Gd Codoped Hydroxyapatite as a Potential Contrast Agent for Tumor-Targeted Biomedical Applications

Doan

et al. 2023

ACS Biomater. Sci. Eng.

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“…Meanwhile, Young's modulus of the samples was lower than that of pure AZ91 alloy (1136 MPa), and this value of AZR15 was decreased to 652 MPa. Its mechanical strength depended on porosity, which depended on its manufacturing process (Es-saddik et al, 2021). During the MAO process, ZrSiO 4 particles could separate into ZrO 2 , thereby reducing the micro-cracks and other defects in the film and affecting the mechanical properties of the samples.…”

Section: Mechanical Propertiesmentioning

confidence: 99%

Effect of ZrSiO4 Concentration on the Microstructure and Corrosion Resistance of MAO Coatings Formed on AZ91 Magnesium Alloy

Chen

Xiang

et al. 2022

Front. Mater.

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As a metallic material with lightweight and high specific strength, magnesium alloy has excellent application prospects. However, the rapid corrosion rate and localized corrosion behavior of magnesium alloys limit the practical application in the automobile industry. In this study, to improve the corrosion resistance of AZ91 alloy, the film of different concentrations containing zirconium (AZR0, AZR5, AZR10, AZR15) was prepared on the surface of AZ91 alloy by micro-arc oxidation technology in the Na2SiO3-Na3PO4 system. Furthermore, the influence of electrolyte composition on the corrosion resistance of the MAO film was systematically investigated. The experimental results revealed that the ZrSiO4 particles added in the electrolyte could enter into the MAO film and ZrSiO4 particles were also decomposed into ZrO2 and Mg2Zr5O11 in the process of micro-arc oxidation. More importantly, the formation of micro-cracks and other defects in the film could be reduced after this process. The addition of 15 g l−1 ZrSiO4 in the electrolyte was contributed to the best comprehensive properties of MAO-processed AZ91 specimens, including improved Vickers hardness of 167.16 Hv, Young’s modulus of 652 MPa, and enhanced corrosion resistance (RP = 9.82 × 105 Ω cm2). This approach could provide the approach for developing Mg-based materials with high anticorrosion in industrial fields.

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Recent trends on biomaterials for tissue regeneration applications: review

Farag

2023

J Mater Sci

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Tissue engineering is approach of replacing or regeneration of biological functions of tissues or organs by using combination of biomaterials, biomolecules and cells. Tissue engineering mainly depends scaffold biomaterials and scaffold fabrication methods. Therefore, there have been progressive investigation and development of new biomaterials with different formulations to help and achieve necessary requirements in the tissue engineering applications. This review is briefly representing necessary features associated with biomaterial type and design required for tissue regeneration applications, and presenting earlier research in tissue engineering field and new trends for future implementation. It is mainly focusing on generations of biomaterials and discovery tissue engineering field. As well as, different types of biomaterials, such as bioceramics, bioactive glasses, synthetic and natural polymers and their derived composites, used in fabrication of scaffolds (as a main part of tissue engineering) are demonstrated in this review. Scaffold fabrication methods are also reviewed here. Moreover, it is showing the recent achievements in tissue engineering field for bone, skin, cartilage, neural, and cardiac regeneration as a pre-clinical procedure for repair of injured and diseased tissues and organs. Finally, recent trends and challenges of biomaterials for tissue regeneration are presented also in this review. Graphical abstract

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Effect of the surface chemistry on the stability and mechanical properties of the Zirconia-Hydroxyapatite bioceramic

Cited by 7 publications

References 25 publications

Yb–Gd Codoped Hydroxyapatite as a Potential Contrast Agent for Tumor-Targeted Biomedical Applications

Yb–Gd Codoped Hydroxyapatite as a Potential Contrast Agent for Tumor-Targeted Biomedical Applications

Effect of ZrSiO4 Concentration on the Microstructure and Corrosion Resistance of MAO Coatings Formed on AZ91 Magnesium Alloy

Recent trends on biomaterials for tissue regeneration applications: review

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