Effect of the sulfonylurea glyburide on glycogen synthesis in alloxan-induced diabetic rat hepatocytes

Atalay, Tuba; Altan, Nilgün; Co, Ongun; Alagöl, H

doi:10.1016/0306-3623(94)90170-8

Cited by 5 publications

(1 citation statement)

References 26 publications

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“…Glib is an important drug for the management of hyperglycaemia in moderate DM (Caro, 1985). Recent studies have shown that Glib is a potent insulin-like agent that promotes glucose uptake, glucose oxidation and activation of glycogen synthase in rat liver and adipocytes (Altan et al, 1985;Atalay et al, 1994). The present work aimed to evaluate the effect CTS-SeNPs to reduce the diabetic complications, toxicity and restore insulin resistance accompanied with diabetes compared to Glib as a pharmaceutical product used in treatment of diabetes in male rats.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of antidiabetic effect of nanoselenium in STZ induced diabetes in rats

zaid

El-Sonbaty

ahmed

2021

Benha Veterinary Medical Journal

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This study was designed to investigate the anti-diabetic effects of selenium nano-particles (SeNPs) at dose of 2 mg/kg body weight in streptozotocin (STZ) induced diabetes in a rat model at dose 50 mg/kg body weight. Rats were administered SeNPs orally in normal and experimentally induced diabetic rats for 35 days and glibenclamide (Glib) at the dose rate of 20 mg/kg, which was used as a reference drug. Blood samples and pancreatic tissue were collected at the end of experiment. Administration of SeNPs significantly decreased blood glucose levels and enhanced serum insulin concentration, the result showed also decrease in liver function enzymes alanine aminotransferase (ALT) and aspartate aminotransferase (AST).All groups showed non-significant changes in serum creatinine levels, decrease in the cardiac function enzymes creatine kinase-MB (CK-MB). Cholesterol, triglyceride, and lowdensity lipoprotein (LDL) levels were significantly decreased and high-density lipoprotein (HDL) was significantly increased. Histological study revealed that SeNPs were able to prevent atrophy of island of Langerhans cells compared to diabetic group. However, Glib injection also exhibited a significant improvement in diabetic animals after 35 days of treatment. This study suggests that SeNPs capped with chitosan can be used as an antidiabetic showing synergistic effect in STZ-induced diabetic rats,. Diabetes mellitusGlibenclamide.

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Section: Introductionmentioning

confidence: 99%