Effect of the Resveratrol Rice DJ526 on Longevity

Abstract

Resveratrol is the best-known chemical for extending the lifespan of various organisms. Extensive recent research has shown that resveratrol can extend the lifespan of single-celled organisms, but its effects on the extension of animal lifespans are marginal. Despite the limited efficacy of pure resveratrol, resveratrol with the endogenous property of the DJ rice in the resveratrol rice DJ526 previously showed profound health benefits. Here, we report that the resveratrol rice DJ526 markedly extended the lifespan of the fruit fly Drosophila melanogaster by as much as 41.4% compared to that of the control. The resveratrol rice DJ526 also improved age-related symptoms such as locomotive deterioration, body weight gain, eye degeneration and neurodegeneration in D. melanogaster upon aging. This result shows the most significantly improved lifespan in animal experiments to date, meaning that the resveratrol rice DJ526 will assist in the development of a therapeutic agent for longevity or addressing age-related degeneration.

Recent Technologies for the Extraction and Separation of Polyphenols in Different Plants: A Review

“…A serial of technologies has been reported for the extraction of polyphenols from plant and biomass, including solvent extraction, supercritical fluid extraction, ultrasonic extraction, enzymatic extraction, [40,41] resin adsorption extraction, and pulsed electric field method. Hence, the recent work for polyphenol isolation by these technologies is comprehensively reviewed in this section.…”

Alteration of resveratrol-dependent glycosyltransferase activity by elicitation in DJ-526 rice

“…Both the callus and seeds of DJ-526 have been reported to have biological and pharmaceutical activities, e.g., cholesterol reduction, 1 whitening effects, 2 extension of the life cycle of fruit flies, 3 improvement of physical strength, and anti-aging properties. 4 However, the utilization of resveratrol is limited by glycosylation, which is a congenital process in plants. Synthesized resveratrol is naturally transformed to its glucoside form and stored in vacuoles to prevent self-toxicity and oxidation.…”

“…Both the callus and seeds of DJ-526 have been reported to have biological and pharmaceutical activities, e.g., cholesterol reduction, 1 whitening effects, 2 extension of the life cycle of fruit flies, 3 improvement of physical strength, and anti-aging properties. 4 …”

Enhancing Resveratrol Bioproduction and Anti-Melanogenic Activities through Elicitation in DJ526 Cell Suspension

“…In DJ526, resveratrol is produced in all tissues, but particularly in the seeds and callus, via expression of the resveratrol synthase (RS) gene of the peanut Palkwang variety. The seeds and callus of DJ526 were shown to possess many potential bioactivities such as caloric restriction [4], physical strength improvement [5], and lifespan extension in fruit flies [6].…”