Effect of the Quantity of Tissue Removed on Regeneration of Organs

Timashkevich, T. B.

doi:10.1007/978-1-4684-8456-4_2

Cited by 2 publications

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“…Alternatively, differences in growth plate regenerative capacity along the length of the hindlimb may indicate differences in the magnitude of the regeneration stimulus, noting that femoral amputations remove a considerably a greater mass and volume of the limb, and expose a greater wound surface, than amputations that divide the tibiofibula. In the former regard it has been shown in studies of regrowth of mammalian viscera that, following incomplete extirpation, the magnitude of the regenerative response is proportional to the quantity of tissue removed (25). In comparing femoral with tibiofibular amputations in the context of this perspective, we estimate that the former removes about twice the volume of limb tissue ablated by the latter.…”

Section: Discussionmentioning

confidence: 97%

Regeneration of growth plate cartilage induced in the neonatal rat hindlimb by reamputation

Libbin

Rivera

1989

Journal Orthopaedic Research

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Following primary hindlimb amputations dividing the lower femur or the central tibiofibula, the neonatal rat innately regenerates the distal growth plate(s) with a frequency of about 20-30%. One or two reamputation procedures were performed in an effort to increase the frequency of physeal regeneration, noting that such procedures, and related forms of tissue stimulation, have been repeatedly shown to induce regenerative growth at limb amputation sites of some amphibians that display little innate regenerative capacity. The present reamputation sequences divided the skeletal stump through the cartilaginous mass arising at its distal end. Following first reamputation an approximate three fold increase in the frequency of growth plate cartilage regeneration was observed at transfemoral and transtibiofibular sites. Only after second reamputation, however, did tibiofibular physeal cartilage regeneration equal in frequency that observed after first reamputation through the lower femur. Ectopic growth plate cell architecture was identified in cartilaginous extensions arising from the side of the distal femoral shaft, and also within the regrown secondary cartilage body, which unites the lower tibia and fibula in the shank of the rat. Moreover, among 3 of 11 femoral amputees that had sustained reamputations, regrowth of the distal femoral condylar mass and profile were achieved to varying degrees. It is concluded that a regimen of reamputation, known to induce regenerative growth in the amphibian limb, also induces skeletal regneration in the mammalian limb, and lead to the appearance of ectopic growth plate cell architecture at adjacent sites.

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Section: Discussionmentioning

confidence: 97%

Regeneration of growth plate cartilage induced in the neonatal rat hindlimb by reamputation

Libbin

Rivera

1989

Journal Orthopaedic Research

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Partial regeneration of the above‐elbow amputated rat forelimb. II. Electrical and mechanical facilitation

Libbin

Person

Papierman

et al. 1979

Journal of Morphology

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This investigation was undertaken to examine the observations of Becker ('72) pertaining to the electrical facilitation of partial limb regenerative responses by means of Ag-Pt wire couples applied to the limb stumps of young, forelimb-amputated white rats. Additionally, in order to examine the possible role of mechanical effects of such device implantations, we have employed uncoupled devices delivering no current or potential difference. In the present experiments, in response to coupled device implantation, cartilage and bone were actively formed in the vicinity of the Pt electrode tip. These tissues contributed to the lengthwise extension of the limb and to the partial restoration of the distal humeral extremity. In limbs bearing the uncoupled electrical devices, qualitatively similar responses were noted, but osteogenesis was diminished in extent compared to that seen in limbs bearing the active or coupled devices. It is therefore necessary to consider the role of mechanical factors in the elicitation of the observed regenerative responses. Myogenesis was enhanced in electrically stimulated limbs, but not in those rats bearing uncoupled devices.

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Effect of the Quantity of Tissue Removed on Regeneration of Organs

Cited by 2 publications

References 0 publications

Regeneration of growth plate cartilage induced in the neonatal rat hindlimb by reamputation

Regeneration of growth plate cartilage induced in the neonatal rat hindlimb by reamputation

Partial regeneration of the above‐elbow amputated rat forelimb. II. Electrical and mechanical facilitation

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