Effect of the proteolytic enzyme serrapeptase on swelling, pain and trismus after surgical extraction of mandibular third molars

Al-Khateeb, Taiseer Hussain; Nusair, Y.M.

doi:10.1016/j.ijom.2007.11.011

Cited by 86 publications

(55 citation statements)

References 22 publications

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“…Previous studies have shown that metalloproteases isolated from Serratia strains have anti-inflammatory effects and thus therapeutic properties (12,19). Proteolytic enzymes that catalyze the hydrolysis of peptide bonds are present in all organisms and are involved in a large variety of physiological and biochemical functions.…”

Section: Discussionmentioning

confidence: 99%

“…It is an effective drug for the treatment of breast engorgement (18) and relieves swelling and pain following maxillary sinus antrostomy (11). Serrapeptase is also used to degrade atherosclerotic plaque and fibrin on the inside of arteries (19,20). In general, this major metalloprotease has been identified in various strains of Serratia (11)(12)(13)(14)(15)(16) and because of its economic significance, particularly as an anti-inflammatory agent (19), this enzyme is currently being produced commercially and under trade names: Serrapeptase, Aniflazym, Danzen, Serrazyme, Serracel and SerraGold is sold (16,18).…”

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confidence: 99%

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Purification and Characterization of 50 kDa ExtracellularMetalloprotease from Serratia sp. ZF03

et al. 2014

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Purification and Characterization of 50 kDa ExtracellularMetalloprotease from Serratia sp. ZF03

et al. 2014

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“…Several methods to control the immediate inflammatory response associated with head and neck surgery have been described and used, including the use of drugs such as analgesics [1][2][3], corticosteroids [3], antibiotics [4], and proteolytic enzymes [5], laser application [6], or physical therapeutic methods like cryotherapy [7] or manual lymph drainage (MLD) [8]. No single modality of management significantly prevents and/or significantly reduces the occurrence of swelling, pain and trismus without potential undesirable side effects.…”

Section: Introductionmentioning

confidence: 99%

Influence of Kinesiologic Tape on Post-operative Swelling After Orthognathic Surgery

Tozzi

Santagata

Sellitto

et al. 2015

J. Maxillofac. Oral Surg.

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Introduction Orthognathic surgery involves making several osteotomies that lead to varying degrees of post-operative swelling. The use of KT may be beneficial for postoperative treatment after head and neck surgery, accelerating drainage of tissue reaction or haemorrhages. The goal of this study was to find out if the application of KT prevents or improves swelling, pain and trismus after orthognathic surgery, improving patients' postoperative quality of life. Materials and Methods In this double-blinded, randomized, control trial, 24 patients in whom bimaxillary orthognathic surgery was indicated, were included. Before surgery each patient alternatively was randomly included in the study group (treated with K-Taping Ò and corticosteroid) or in the control group (treated with corticosteroid). In the present study a MakerBot Ò Digitizer 3D TM was used to assess accurate volume measurements. All swelling measurements were expressed as total 3-D area of the landmarks (cm 2 ) in T0 pre-operative, T1 fourth day after surgery. Results The differences T0-T1 are highly significant (p \ 0.01) between group 1 or study group (treated with K-taping Ò ) and group 2 (control group). Discussion The use of KT appears promising, because it is simple to carry out, less traumatic, economical, can be performed everywhere in the world, free from side effects on the body. Even when swelling persists, KT gives patients the impression of a minor swelling detracting them from their pain and morbidity. Further studies have to be performed to find out if KT can reduce or replace the need for additional medications such as the use of steroids.

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“…Murugesan et al [40] carried out a randomized study on 110 patients to evaluate the usefulness of serratiopeptidase compared to dexamethasone in impacted lower third molar surgery. Postoperatively, 1 mg dexamethasone was given thrice daily in the first group and 10 mg serratiopeptidase was given thrice daily in the second group for 3 days.…”

Section: Third Molar Surgerymentioning

confidence: 99%

The Emerging Role of Serratiopeptidase in Oral Surgery: Literature Update

Kumar

2018

Asian J Pharm Clin Res

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Serratiopeptidase, a proteolytic enzyme derived from Serratia E-15 species enterobacteria, is widely used in medical field for its anti-inflammatory, anti-edemic properties, and analgesic properties. It is being used commonly in various specialties such as orthopedics, otolaryngology, gynecology, surgery, pulmonology, ophthalmology, and dentistry. Research has shown that serratiopeptidase is the most effective anti-inflammatory agent compared to other enzyme preparations. This article reviews the efficacy, safety, and applications of serratiopeptidase in oral surgery. This article also discusses the mechanism of action of serratiopeptidase, its contraindications and complications. From the recently published literature, it is clear that the role of serratiopeptidase as a therapeutic agent in oral and maxillofacial surgery is expanding and they hold a promising future as a broad-spectrum anti-inflammatory drug with minimal side effects and complications. Further, research will broaden their applications in the field of medicine and dentistry.

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Effect of the proteolytic enzyme serrapeptase on swelling, pain and trismus after surgical extraction of mandibular third molars

Cited by 86 publications

References 22 publications

Purification and Characterization of 50 kDa ExtracellularMetalloprotease from Serratia sp. ZF03

Purification and Characterization of 50 kDa ExtracellularMetalloprotease from Serratia sp. ZF03

Influence of Kinesiologic Tape on Post-operative Swelling After Orthognathic Surgery

The Emerging Role of Serratiopeptidase in Oral Surgery: Literature Update

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