Effect of the probiotic<i>Lactobacilli reuteri</i>(Prodentis) in the management of periodontal disease: a preliminary randomized clinical trial

Rangaraju, Vivekananda M; Vandana, K L; Bhat, Kishore

doi:10.3402/jom.v2i0.5344

Cited by 225 publications

(356 citation statements)

References 29 publications

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“…Although probiotics have only included commensal bacteria and shown their usefulness as an adjunct therapy in chronic periodontitis, 21,22 P. gingivalis strains with a low virulence may be also used for the prevention of colonization or replacement of highly virulent P. gingivalis. The aims of the present study were to identify a P. gingivalis strain with a low virulence among clinical isolates based on its invasive ability and cytokine proteolytic activities, and to explore the preferential degradation of a certain cytokine by P. gingivalis.…”

Section: Introductionmentioning

confidence: 99%

Association of the invasion ability ofPorphyromonas gingivaliswith the severity of periodontitis

Baek

Ji²,

Kim

et al. 2015

Virulence

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(2015) Association of the invasion ability of Porphyromonasgingivalis with the severity of periodontitis, Virulence, 6:3, 274-281, DOI: 10.1080/21505594.2014 Keywords: cytokine proteolytic activity, invasion ability, Porphyromonas gingivalis, periodontitis, severityPorphyromonas gingivalis is one of the well-characterized periodontal pathogens involved in periodontitis. The invasive and proteolytic activities of P. gingivalis clinical isolates have been shown to be associated with heterogenic virulence, as determined in a mouse abscess model. The aims of the present study were to identify a P. gingivalis strain with a low virulence among clinical isolates, based on its invasive ability and cytokine proteolytic activities, and to explore the preferential degradation of a certain cytokine by P. gingivalis. P. gingivalis ATCC 33277, W50, and 10 clinical isolates were used. After incubating bacteria with IL-4, IL-6, IL-10, IL-17A, TNFa, IFNg, and IL-1a, the amounts of remaining cytokines were determined by ELISA. Invasion ability was measured by a flow cytometric invasion assay. There was inter-strain variability both in the cytokine proteolytic activities and invasion ability. In addition, differential degradation of cytokines by P. gingivalis was observed: while IFNg and IL-17A were almost completely degraded, inflammatory cytokines TNFa and IL-1a were less susceptible to degradation. Interestingly, the invasion index, but not cytokine proteolytic activities, of P. gingivalis had strong positive correlations with clinical parameters of subjects who harbored the isolates. Therefore, the invasive ability of P. gingivalis is an important virulence factor, and the bacterial invasion step may be a good target for new therapeutics of periodontitis.

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Section: Introductionmentioning

confidence: 99%

Association of the invasion ability ofPorphyromonas gingivaliswith the severity of periodontitis

Baek

Ji²,

Kim

et al. 2015

Virulence

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“…The use of probiotics in oral care applications is gaining momentum [118]. There is increasing evidence that the use of existing probiotic strains can deliver oral health benefits.…”

Section: Discussionmentioning

confidence: 99%

“…However, the level of this reduction was higher in SRP + probiotic, and lower, in placebo (p <0.05). Probiotic, with or without SRP, reduced significantly P. gingivalis, A. actinomycetemcomitans and P. intermedia [118].…”

Section: Probiotics and Periodontitismentioning

confidence: 97%

“…The bacteria most frequently used as probiotic are L. reuteri (DSM 17938 + ATCC PTA 5289) [72,[118][119][120], Lactibacillus salivarius WB21 [121,122], L. reuteri (ATCC 55730 + ATCC PTA 5289) [123], L. reuteri (ATCC PTA 5289) [61], Streptoccus oralis KJ3 + Streptococcus uberis KJ2 + Streptoccus rattus JH145 [124] and L. rhamnosus SP1 [125].…”

Section: Probiotics and Periodontitismentioning

confidence: 99%

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Probiotics and Periodontal Diseases

Morales¹,

Bravo²,

Bedoya³

et al. 2017

Insights Into Various Aspects of Oral Health

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Probiotics are defined as live microorganisms that, when administered in adequate amounts, confer a health benefit on the host. Probiotics have been used to directly modify the resident oral microbiome and proposed to modulate immune responses. In dentistry, probiotics have been employed as useful adjuncts for the reduction of caries development, suppressing oral Candida infection and controlling halitosis. Plaque-induced gingivitis is a gingival inflammation caused by the adherent bacterial biofilm around teeth. Gingivitis and periodontitis are considered to be a continuum of the same inflammatory process, although many gingivitis lesions do not progress to periodontitis. Periodontitis is an inflammatory process that affects the attachment structures of teeth. It constitutes a second cause of tooth loss worldwide. Conventional treatment modalities of periodontal disease include non-surgical and/or surgical management, with an emphasis on mechanical debridement. However, mechanical debridement as a sole therapy is not always effective to improve clinical parameters. A growing number of studies support probiotic therapy to prevent or treat gingivitis and periodontitis. Oral administration of probiotics is an effective adjunct in reducing pathogenic bacteria and improving clinical signs of disease. Probiotics may serve as adjunct or replacement therapy substitute antibiotics in managing human periodontal infections in future.

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“…Only for black-pigmented anaerobic rods, which include most periodontopathic bacteria, a significant decrease was found [50]. A promising strain is also L. reuteri Prodentis, because not only antimicrobial, but also inflammatory, effects were found along with inhibition of plaque formation [51]. The reduction of proinflammatory cytokines (TNF-α, IL-8) in gingival crevicular fluid can be regarded proof of concept for the application of Lactobacillus reuteri in a chewing gum.…”

Section: Periodontal Diseasementioning

confidence: 99%

Lactobacilli for the Treatment of Oral Diseases

Hoffmann¹,

Daniels²

2017

J Prob Health

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Probiotics are defined as live microorganisms that beneficially affect the host. Probiotic bacteria have been used therapeutically for years to target gastrointestinal disease by rebalancing the complex microflora. Besides the gastrointestinal tract also the oral cavity is highly colonized by bacteria and many different bacterial species are part of the microbiota in the mouth, as it offers ideal conditions for bacteria with a stable temperature, moist surface with a relatively stable pH and regular supply of nutrients. By disturbing the balance of microorganisms in the oral cavity or by extensive accumulation of plaque, the ratio of pathogenic organisms can increase and lead to oral health problems. Probiotic bacteria, like lactobacilli, are a promising treatment strategy for oral diseases with a microbiological aetiology. Those include plaqueassociated diseases like dental caries, which is an infectious disease with microbial processes eroding and destroying the hard dental tissue or inflammation of periodontal tissue, namely gingivitis and the more severe periodontitis. Moreover, endodontic infections, and even fungal, viral and acute bacterial infections could be treated by a probiotic therapy. The interest of probiotics in the field of oral health is growing, although it is still in its infancy. The present review adresses criteria for the selection of probiotic lactobacilli strains. It encompasses existing evidence on the use of lactobacilli for caries, halitosis and candidiasis, as well as for periodontal disease like Gingivitis and periodontitis.

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Effect of the probioticLactobacilli reuteri(Prodentis) in the management of periodontal disease: a preliminary randomized clinical trial

Cited by 225 publications

References 29 publications

Association of the invasion ability ofPorphyromonas gingivaliswith the severity of periodontitis

Association of the invasion ability ofPorphyromonas gingivaliswith the severity of periodontitis

Probiotics and Periodontal Diseases

Lactobacilli for the Treatment of Oral Diseases

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