Effect of the pretreatment with acerola (Malpighia emarginata DC.) juice on ethanol-induced oxidative stress in mice – Hepatoprotective potential of acerola juice

Abstract

Background and objectives: Acerola (Malpighia emarginata DC.) is a tropical fruit known for its nutritional and functional properties due to its great contents vitamin C, carotenoids and anthocyanins. The antioxidant potential from plants extracts associated to hepatoprotective activity has been widely studied. However, the effect of antioxidants in natural fruit juice has not been fully searched. The aim of this work was to investigate the antioxidant properties of acerola juice and its hepatoprotective potential against acute ethanol-induced stress. Materials and methods: Ripe acerola were collected, processed into juice and initially analyzed to antioxidant properties in vitro. Afterwards, in vivo hepatoprotective activity was evaluated in mice. The animals received the juice by gavage as pretreatment for 15 consecutive days and then, were submitted to ethanol-induced stress in single dose (5 g/kg). The activities of serum enzymes as well as lipid peroxidation degree were evaluated. The activities of serum marker enzymes for liver damage as well as lipid peroxidation degree were evaluated. Results: Acerola juice presents great vitamin C (1799.5 mg/100 g FW) and total phenolic (188.4 mg GAE/ 100 g FW), anthocyanins (9.2 mg/100 g FW), flavonols (7.8 mg/100 g FW) contents and high activity of superoxide dismutase (1053.6 UA/g DM) with a total antioxidant activity of 137.5 mmol Trolox/g FW. The juice treatment inhibited lipid peroxidation and reduced the activities of aminotransferases (p 0.05), in mice liver. Conclusion: These results indicate that acerola juice is able to prevent the hepatic damage induced by ethanol, probably as a result of an enhancement of the antioxidant status in the animals.

Antioxidative Response in a Silkworm, Bombyx mori larvae to Dichlorvos insecticide

“…An increased activity of SOD in acerola juice revealed that SOD plays an important role in dismutation of superoxide radicas. 22 Mahmud et al 23 also found a potential antioxidant activity of SOD against carbon tetrachloride induced liver damage in rats. Previous study reported that induction of SOD activity is the main response to organophosphate toxicity and other dietary prooxidant exposure in lepidopteran insectS 9,24 CAT catalyzes the conversion of hydrogen peroxide to water and molecular oxygen.…”

Acerola (Malpighia spp.) Waste: A Sustainable Approach to Nutraceutical, Pharmaceutical, and Energy Applications

“…A complete characterization of other parts and tissues of this plant could yield new and valuable information on other properties that could differ from those of other structures analyzed. Antihyperglycemic: [16], antitumor: [26] Antigenotoxic: [27]; Hepatoprotective: [16,28,29], Antimutagenic: [16], Antimicrobial: [17,24], Antiobesity: [25]; Antifungal: [22,30], , Free radical scavenging: [30]. ; Anti-inflamatory: [16], Antihyperglycemic: [16], antitumor: [26] Antigenotoxic: [27]; Hepatoprotective: [16,28,29], Antimutagenic: [16], Antimicrobial: [17,24], Antiobesity: [25]; Antifungal: [22,30], Free radical scavenging: [30].…”

“…Antihyperglycemic: [16], antitumor: [26] Antigenotoxic: [27]; Hepatoprotective: [16,28,29], Antimutagenic: [16], Antimicrobial: [17,24], Antiobesity: [25]; Antifungal: [22,30], , Free radical scavenging: [30]. ; Anti-inflamatory: [16], Antihyperglycemic: [16], antitumor: [26] Antigenotoxic: [27]; Hepatoprotective: [16,28,29], Antimutagenic: [16], Antimicrobial: [17,24], Antiobesity: [25]; Antifungal: [22,30], Free radical scavenging: [30]. (1980) and Brücher (1989) [20,21].…”

“…No literature was found concerning the properties of the Malpighia spp flowers (figure self-made). References for Activity: Antioxidative: [22][23][24][25]; Anti-inflamatory:[16 Antihyperglycemic: [16], antitumor: [26] Antigenotoxic: [27]; Hepatoprotective: [16,28,29 Antimutagenic: [16], Antimicrobial: [17,24], Antiobesity: [25]; Antifungal: [22,30], , Free radica scavenging: [30].…”

Encapsulation of W/O/W Acerola Emulsion by Spray Drying: Optimization, Release Kinetics, and Storage Stability

“…Acerola (Malpighia emarginata DC.) is indigenous to the Caribbean and is renowned for its numerous health benefits, including its antihyperglycemic effect [1], hepatoprotective effect [2], skin lightening [3], and its potential in preventing hyperglycemia and dyslipidemia in diabetic individuals [4]. Acerola fruits are particularly notable for their exceptionally high vitamin C content, ranging from 1500 to 4500 mg per 100 g, which is approximately 50 to 100 times higher than that of oranges or lemons [5].…”