Effect of the preparation method on the drug loading of alginate-chitosan microspheres

Abreu, Flávia Oliveira Monteiro da Silva; Forte, Maria M.C.; Kist, Tarso B. Ledur; Honaiser, L. P.

doi:10.3144/expresspolymlett.2010.58

Cited by 18 publications

(8 citation statements)

References 21 publications

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“…The above finding was similar to the reports presented previously [ 42 , 43 ]. Comparing the effectiveness of preparation methods, Abreu et al (2010) observed that particles produced in water-in-oil emulsion method presented relatively higher EE values [ 44 ].…”

Section: Resultsmentioning

confidence: 99%

Antibacterial Activity of Ciprofloxacin-Encapsulated Cockle Shells Calcium Carbonate (Aragonite) Nanoparticles and Its Biocompatability in Macrophage J774A.1

Isa

Zakaria

Rukayadi

et al. 2016

IJMS

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The use of nanoparticle delivery systems to enhance intracellular penetration of antibiotics and their retention time is becoming popular. The challenge, however, is that the interaction of nanoparticles with biological systems at the cellular level must be established prior to biomedical applications. Ciprofloxacin–cockle shells-derived calcium carbonate (aragonite) nanoparticles (C-CSCCAN) were developed and characterized. Antibacterial activity was determined using a modified disc diffusion protocol on Salmonella Typhimurium (S. Typhimurium). Biocompatibilittes with macrophage were evaluated using the 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and 5-Bromo-2′-deoxyuridine (BrdU) assays. Transcriptional regulation of interleukin 1 beta (IL-1β) was determined using reverse transcriptase-polymerase chain reaction (RT-PCR). C-CSCCAN were spherical in shape, with particle sizes ranging from 11.93 to 22.12 nm. Encapsulation efficiency (EE) and loading content (LC) were 99.5% and 5.9%, respectively, with negative ζ potential. X-ray diffraction patterns revealed strong crystallizations and purity in the formulations. The mean diameter of inhibition zone was 18.6 ± 0.5 mm, which was better than ciprofloxacin alone (11.7 ± 0.9 mm). Study of biocompatability established the cytocompatability of the delivery system without upregulation of IL-1β. The results indicated that ciprofloxacin–nanoparticles enhanced the antibacterial efficacy of the antibiotic, and could act as a suitable delivery system against intracellular infections.

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Section: Resultsmentioning

confidence: 99%

Antibacterial Activity of Ciprofloxacin-Encapsulated Cockle Shells Calcium Carbonate (Aragonite) Nanoparticles and Its Biocompatability in Macrophage J774A.1

Isa

Zakaria

Rukayadi

et al. 2016

IJMS

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“…Besides, it equally possesses Immunological, mucoadhesive, antitumoral hemostatic and anticoagulant, healing, bacteriostatic ability. Chitosomes are also an excellent drug loading and delivering system [96].…”

Section: Food Applications Of Chitosanmentioning

confidence: 99%

Ultrasonic Modification of Selected Polysaccharides-Review

Ogutu¹,

Mu²,

Elahi³

et al. 2015

J Food Process Technol

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This review is a survey on ultrasonic application in selected carbohydrate polymers based upon available research reports. It covers a brief discussion on the fundamentals of ultrasound technology, before delving on the effects of ultrasound on specific polymers; pectin, chitin, starch, carrageenan and guar gum, their modification products and possible applications in food, pharmaceutical, biomedical and packaging sectors. Sonication generally leads to depolymerization and side chain break within molecules resulting into oligosugars. Oligosugars are widely used as prebiotics and specific delivery systems; moreover, nano sized products of sonication can be applied in diverse fields. Presently, ultrasonic is finding application in wider sectors therefore better understanding of the complex physico-chemical changes and mechanism of the action of high-intensity ultrasound and its effect on techno-functional properties of compounds would immensely fortify the application of ultrasonic technology.

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“…Another research group illustrated the success of this approach in enhancing the encapsulation of lisinopril. 69 Alginate-coated chitosan microspheres have also been reported as good vectors for oral administration of protein and peptides, such as insulin with enhanced insulin stability, sustained-release effect, and ability to reduce the blood glucose level in diabetic rats for more than 60 hours following oral administration. 70 Another way to decrease the burst effect and enhance stability in pure chitosan microspheres was achieved by formation of polymer/layered silicate composites.…”

Section: Chitosan Micro-/nanoparticles As Drug Delivery Systemmentioning

confidence: 99%

Preparation, characterization, and potential application of chitosan, chitosan derivatives, and chitosan metal nanoparticles in pharmaceutical drug delivery

Ahmed¹,

Aljaeid²

2016

DDDT

508

254

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Naturally occurring polymers, particularly of the polysaccharide type, have been used pharmaceutically for the delivery of a wide variety of therapeutic agents. Chitosan, the second abundant naturally occurring polysaccharide next to cellulose, is a biocompatible and biodegradable mucoadhesive polymer that has been extensively used in the preparation of micro-as well as nanoparticles. The prepared particles have been exploited as a potential carrier for different therapeutic agents such as peptides, proteins, vaccines, DNA, and drugs for parenteral and nonparenteral administration. Therapeutic agent-loaded chitosan micro- or nanoparticles were found to be more stable, permeable, and bioactive. In this review, we are highlighting the different methods of preparation and characterization of chitosan micro- and nanoparticles, while reviewing the pharmaceutical applications of these particles in drug delivery. Moreover, the roles of chitosan derivatives and chitosan metal nanoparticles in drug delivery have been illustrated.

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Effect of the preparation method on the drug loading of alginate-chitosan microspheres

Cited by 18 publications

References 21 publications

Antibacterial Activity of Ciprofloxacin-Encapsulated Cockle Shells Calcium Carbonate (Aragonite) Nanoparticles and Its Biocompatability in Macrophage J774A.1

Antibacterial Activity of Ciprofloxacin-Encapsulated Cockle Shells Calcium Carbonate (Aragonite) Nanoparticles and Its Biocompatability in Macrophage J774A.1

Ultrasonic Modification of Selected Polysaccharides-Review

Preparation, characterization, and potential application of chitosan, chitosan derivatives, and chitosan metal nanoparticles in pharmaceutical drug delivery

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