Effect of the polymer matrix on the properties of fibres prepared by sintering polymer dispersions

Koldobskii, A. L.; Dreizenshtok, G. S.; Sorokin, E. Ya.; Perepelkin, K. E.; Slin'ko, L. V.

doi:10.1007/bf00544947

Cited by 2 publications

(2 citation statements)

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“…Usually high‐molecular‐weight PTFE is classified as nonmelt processable, because of its high‐melt viscosity 4. Conventional processing technique for converting PTFE into fibers involves multiple steps, such as formation of kerosene/PTFE paste followed by stretching and sintering5–7 or creation of PTFE/matrix polymer emulsion followed by emulsion spinning and sintering 8, 9. Because these processes involve the usage of large amount of solvent or decomposition of emulsion matrix, it is highly desired to develop a technique capable of processing PTFE fiber in a simple and environment friendly manner.…”

Section: Introductionmentioning

confidence: 99%

The molecular basis of skeletal muscle weakness in a mouse model of inflammatory myopathy

Coley¹,

Rayavarapu²,

Pandey³

et al. 2012

Arthritis & Rheumatism

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OBJECTIVE It is generally believed that muscle weakness in patients with polymyositis and dermatomyositis is due to autoimmune and inflammatory processes. However, it has been observed that there is a poor correlation between the suppression of inflammation and a recovery of muscle function in patients. We have therefore hypothesized that non-immune mechanisms also contribute to muscle weakness. In particular, it has been suggested that an acquired deficiency of AMP deaminase (AMPD1) may be responsible for muscle weakness in myositis. METHODS We have used comprehensive functional, behavioral, histological, molecular, enzymatic and metabolic assessments before and after the onset of inflammation in MHC class I mouse model of autoimmune inflammatory myositis. RESULTS We found that muscle weakness and metabolic disturbances were detectable in the mice prior to the appearance of infiltrating mononuclear cells. Force contraction analysis of muscle function revealed that weakness was correlated with AMDP1 expression and was myositis-specific. We also demonstrated that decreasing AMPD1 expression results in decreased muscle strength in healthy mice. Fiber typing suggested that fast-twitch muscles are converted to slow-twitch muscles as myositis progresses, and microarray results indicated that AMPD1 and other purine nucleotide pathway genes are suppressed, along with genes essential to glycolysis. CONCLUSION These data suggest that an AMPD1 deficiency is acquired prior to overt muscle inflammation and is responsible, at least in part, for the muscle weakness that occurs in the mouse model of myositis. AMPD1 is therefore a potential therapeutic target in myositis.

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Section: Introductionmentioning

confidence: 99%

The molecular basis of skeletal muscle weakness in a mouse model of inflammatory myopathy

Coley¹,

Rayavarapu²,

Pandey³

et al. 2012

Arthritis & Rheumatism

View full text Add to dashboard Cite

show abstract

“…4 Conventional processing technique for converting PTFE into fibers involves multiple steps, such as formation of kerosene/PTFE paste followed by stretching and sintering [5][6][7] or creation of PTFE/matrix polymer emulsion followed by emulsion spinning and sintering. 8,9 Because these processes involve the usage of large amount of solvent or decomposition of emulsion matrix, it is highly desired to develop a technique capable of processing PTFE fiber in a simple and environment friendly manner. Recently, Badding and coworkers 10 tried jet blow high-molecular-weight PTFE both above and below its melting point.…”

Section: Introductionmentioning

confidence: 99%

Melt processability of polytetrafluoroethylene: Effect of melt treatment on tensile deformation mechanism

Zhang

Wang

et al. 2011

J of Applied Polymer Sci

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It is widely accepted that the melt processibility of polytetrafluoroethylene (PTFE) is poor. In this article, a high-molecular-weight PTFE was extruded smoothly with a modified die; and critical shear rate could be raised to 4 s À1, using a die with L/D (length to diameter) ratio of 200. Meanwhile, we compared the current PTFE fiber spinning method with melt spinning to investigate the effects of high-temperature treatment on the drawability of PTFE and found that the processing sequence could play a key role. The deformation imposed before or after the high-temperature treatment could determine whether the fibrillation can be achieved continuously and effectively. Based on the experiment phenomenon, together with the results of differential scanning calorimetry, X-ray diffraction, and scanning electron microscopy characterization, we proposed a model to describe the submicron structural change of PTFE during extension. From this model, the fundamental mechanism for the poor melt processibility of PTFE was elucidated.

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Effect of the polymer matrix on the properties of fibres prepared by sintering polymer dispersions

Cited by 2 publications

References 0 publications

The molecular basis of skeletal muscle weakness in a mouse model of inflammatory myopathy

The molecular basis of skeletal muscle weakness in a mouse model of inflammatory myopathy

Melt processability of polytetrafluoroethylene: Effect of melt treatment on tensile deformation mechanism

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