Effect of the Peripheral Trpm8 Ion Channel Activation on the Cardiovascular Parameters

Tv, Kozyreva; Vp, Kozaruk; Es, Meyta

doi:10.23937/2572-3987.1510019

Cited by 3 publications

(2 citation statements)

References 20 publications

(21 reference statements)

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“…In the study of the impact of peripheral ion channel TRPM8 activation by menthol on some parameters of the cardiovascular system [ 20 ], a pronounced influence of this channel’s stimulation was detected that was aimed at increasing blood pressure in normotensive animals; in hypertensive animals, these responses were weaker. On the basis of those results and the data about decreased Trpm8 gene expression in hypertensive animals, the authors concluded that the downregulation of the TRPM8 ion channel may be a compensatory response aimed at preventing a blood pressure surge.…”

Section: Discussionmentioning

confidence: 99%

Effect of Skin Ion Channel TRPM8 Activation by Cold and Menthol on Thermoregulation and the Expression of Genes of Thermosensitive TRP Ion Channels in the Hypothalamus of Hypertensive Rats

Voronova

Khramova

Evtushenko

et al. 2022

IJMS

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ISIAH (inherited stress-induced arterial hypertension) rats are characterized by high blood pressure and decreased Trpm8 gene expression in the anterior hypothalamus. Thermosensitive ion channel TRPM8 plays a critical role in the transduction of moderately cold stimuli that give rise to cool sensations. In normotensive animals, the activation of skin TRPM8 is known to induce changes in gene expression in the hypothalamus and induce alterations of thermoregulatory responses. In this work, in hypertensive rats, we studied the effects of activation of the peripheral TRPM8 by cooling and by application of a 1% menthol suspension on (1) the maintenance of body temperature balance and (2) mRNA expression of thermosensitive TRP ion channels in the hypothalamus. In these hypertensive animals, (1) pharmacological activation of peripheral TRPM8 did not affect the thermoregulatory parameters either under thermoneutral conditions or during cold exposure; (2) the expression of Trpm8 in the anterior hypothalamus approximately doubled (to the level of normotensive animals) under the influence of (a) slow cooling and (b) at pharmacological activation of the peripheral TRPM8 ion channel. The latter fact seems the quite important because it allows the proposal of a tool for correcting at least some parameters that distinguish a hypertensive state from the normotensive one.

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Section: Discussionmentioning

confidence: 99%

Effect of Skin Ion Channel TRPM8 Activation by Cold and Menthol on Thermoregulation and the Expression of Genes of Thermosensitive TRP Ion Channels in the Hypothalamus of Hypertensive Rats

Voronova

Khramova

Evtushenko

et al. 2022

IJMS

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“…We would like to draw attention to the fact that our previous studies on the effect of activation of another cold-sensitive ion channel TRMP8 showed its opposite effect on blood pressure. Activation of the TRPM8 ion channel by its agonist menthol contributes to raising blood pressure [23]. Moreover, in hypertensive animals, the expression of the TRMP8 ion channel gene is reduced [24], which can be regarded as a compensatory change.…”

Section: Conflicts Of Interestmentioning

confidence: 99%

Effect of Various Activation of the Skin TRPA1 Ion Channel on Cardiovascular Systemic Parameters in Hypertensive Rats

Tv¹,

Es²

2021

Int Arch Clin Pharmacol

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The effect of different activation of the skin TRPA1 ion channel on the parameters of the cardiovascular system was studied in rats with hereditary stress-induced hypertension while recovery from anesthesia. The activation of the TRPA1 ion channel was performed by application to skin its agonist -allyl isothiocyanate (AITC) in two concentrations 2.5% and 0.5%. The following parameters were measured that characterize the work of the cardiovascular system: Blood pressure (systolic, diastolic, and mean), heart rate, blood flow, and tail blood volume. Stimulation of the TRPA1 ion channel by 2.5% AITC resulted in a diminishing rate of increase in blood pressure and a sharp increase in heart rate while recovering from anesthesia. The mean rate of the arterial pressure rise during recovery from anesthesia was 0.4 ± 0.16 mmHg/min compared to 1.4 ± 0.19 mmHg/ min in control (solvent application), P < 0.01. The heart rate increase was 4.7 ± 0.28 beats/min2 compared to 0.6 ± 0.39 beats/min2 in control (P < 0.001). Parameters of blood flow and the tail blood volume were not significantly changed at 2.5% AITC compared to control. The effect of 0.5% AITC on cardiovascular parameters was another. There was no influence on the recovery of arterial pressure and the heart rate, but there was a pronounced acceleration in the recovery of blood flow and tail blood volume after anesthesia. The mean rate for blood flow recovery at 0.5% AITC application was 0.3 ± 0.07 ml/min2 against 0.1 ± 0.05 ml/min2 in control (P < 0.03) and for the tail blood volume was 1.2 ± 0.33 μl/ min against 0.4 ± 0.14 μl/min in control (P < 0.02). Thus, the influence of the skin TRPA1 ion channel on the parameters of the cardiovascular system depends on the degree of its activation. A low level of the TRPA1 stimulation enhanced the blood flow, while a higher level of the TRPA1 activation discouraged to increase in arterial pressure and significantly increased the heart rate. The results suggest the possibility of the therapeutic use of TRPA1 ion channel activation.

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Population-enriched innate immune variants may identify candidate gene targets at the intersection of cancer and cardio-metabolic disease

Yeyeodu,

Hanafi,

Webb

et al. 2024

Front. Endocrinol.

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Both cancer and cardio-metabolic disease disparities exist among specific populations in the US. For example, African Americans experience the highest rates of breast and prostate cancer mortality and the highest incidence of obesity. Native and Hispanic Americans experience the highest rates of liver cancer mortality. At the same time, Pacific Islanders have the highest death rate attributed to type 2 diabetes (T2D), and Asian Americans experience the highest incidence of non-alcoholic fatty liver disease (NAFLD) and cancers induced by infectious agents. Notably, the pathologic progression of both cancer and cardio-metabolic diseases involves innate immunity and mechanisms of inflammation. Innate immunity in individuals is established through genetic inheritance and external stimuli to respond to environmental threats and stresses such as pathogen exposure. Further, individual genomes contain characteristic genetic markers associated with one or more geographic ancestries (ethnic groups), including protective innate immune genetic programming optimized for survival in their corresponding ancestral environment(s). This perspective explores evidence related to our working hypothesis that genetic variations in innate immune genes, particularly those that are commonly found but unevenly distributed between populations, are associated with disparities between populations in both cancer and cardio-metabolic diseases. Identifying conventional and unconventional innate immune genes that fit this profile may provide critical insights into the underlying mechanisms that connect these two families of complex diseases and offer novel targets for precision-based treatment of cancer and/or cardio-metabolic disease.

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Effect of the Peripheral Trpm8 Ion Channel Activation on the Cardiovascular Parameters

Cited by 3 publications

References 20 publications

Effect of Skin Ion Channel TRPM8 Activation by Cold and Menthol on Thermoregulation and the Expression of Genes of Thermosensitive TRP Ion Channels in the Hypothalamus of Hypertensive Rats

Effect of Skin Ion Channel TRPM8 Activation by Cold and Menthol on Thermoregulation and the Expression of Genes of Thermosensitive TRP Ion Channels in the Hypothalamus of Hypertensive Rats

Effect of Various Activation of the Skin TRPA1 Ion Channel on Cardiovascular Systemic Parameters in Hypertensive Rats

Population-enriched innate immune variants may identify candidate gene targets at the intersection of cancer and cardio-metabolic disease

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