Effect of the oral administration of Lactobacillus brevis subsp. coagulans on interferon-alpha producing capacity in humans.

Kishi, Atsuko; Uno, Kazuko; Matsubara, Y; Okuda, Chikao; Kíshida, Tsunataro

doi:10.1080/07315724.1996.10718617

Cited by 87 publications

(53 citation statements)

References 31 publications

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“…The ability of probiotic LAB to stimulate the human immune system has been demonstrated in previous studies (de Simone et al, 1986Simone et al, , 1991Solis-Pereyra & Lemmonier, 1991;Link-Amster et al, 1994;Schiffrin et al, 1995;Kishi et al, 1996). In particular, dietary consumption of some strains of LAB has been shown to enhance cellular immune responses, including phagocytosis, lymphocyte proliferation and cytokine production (de Simone et al, 1986;LinkAmster et al, 1994;Schiffrin et al, 1995).…”

Section: Discussionmentioning

confidence: 81%

“…It is well known that some strains of LAB can enhance cellular immune function, either innate or speci®c, when used as a probiotic (de Simone et al, 1986(de Simone et al, , 1991SolisPereyra & Lemmonier, 1991;Link-Amster et al, 1994;Schiffrin et al, 1995;Kishi et al, 1996). However, studies conducted to date have generally indicated a positive effect on one particular cellular function, such as phagocytosis or cytokine-secreting activity (Schiffrin et al, 1995;Kishi et al, 1996;Donnet-Hughes et al, 1999).…”

Section: Introductionmentioning

confidence: 99%

“…However, studies conducted to date have generally indicated a positive effect on one particular cellular function, such as phagocytosis or cytokine-secreting activity (Schiffrin et al, 1995;Kishi et al, 1996;Donnet-Hughes et al, 1999). Our laboratory has recently identi®ed and characterised a new strain of Bi®dobacterium lactis (B. lactis HN019) which has potent enhancing properties on several aspects of cellular immunity in animal models (Gill, 1998;Prasad et al, 1999).…”

Section: Introductionmentioning

confidence: 99%

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Enhancing immunity by dietary consumption of a probiotic lactic acid bacterium (Bifidobacterium lactis HN019): optimization and definition of cellular immune responses

et al. 2000

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Objective: To de®ne the cellular basis for immune enhancement by a probiotic lactic acid bacteria strain (Bi®dobacterium lactis HN019); and to determine whether immune enhancement can be optimized by delivery in oligosaccharide-enriched low-fat milk. Design: A double-blind, three-stage before-and-after intervention trial. Setting: Taipei Medical College Hospital, Taipei, Taiwan. Subjects: Fifty healthy Taiwanese citizens (age range 41 ± 81; median 60) randomly allocated to two groups. Interventions: In stage 1 (run-in control stage) all subjects consumed reconstituted low-fat milk (LFM) for 3 weeks; in stage 2 (probiotic intervention) subjects consumed B. lactis in LFM (group A) or B. lactis in lactosehydrolysed LFM (group B) for 3 weeks; in stage 3 all subjects returned to non-supplemented LFM for a further 3 weeks (washout stage). The innate immune functions of two different leucocyte types (polymorphonuclear (PMN) cells and natural killer (NK) cells) were assessed at four time points via in vitro analyses on peripheral blood samples. Results: While consumption of LFM alone had no signi®cant effect on immune responses, stage 2 results indicated signi®cantly enhanced PMN cell phagocytosis and NK cell tumour killing activity following consumption of milk containing B. lactis. These increases levelled off following cessation of B. lactis consumption, but remained above the pre-treatment values. Increases in PMN and NK cell activity were greatest among subjects who consumed B. lactis in lactose-hydrolysed LFM. Conclusions: Dietary consumption of the probiotic bacterium B. lactis HN019 enhanced immune function of two different types of leucocytes; the degree of enhancement was increased by consuming B. lactis in an oligosaccharide-rich substrate. Sponsorship: Financial support was provided by the New Zealand Dairy Board.

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Section: Discussionmentioning

confidence: 81%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Enhancing immunity by dietary consumption of a probiotic lactic acid bacterium (Bifidobacterium lactis HN019): optimization and definition of cellular immune responses

et al. 2000

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“…According to Kishi et al (1996), the effect of lactobacilli on the immune system depends on the dose. A higher intake of bacteria resulting in a superior response compared with a lower intake.…”

Section: Discussionmentioning

confidence: 99%

The Influence of Short-term and Continuous Administration of Lactobacillus casei on Basic Haematological and Immunological Parameters in Gnotobiotic Piglets

Herich¹,

Bomba²,

Nemcová³

et al. 1999

Food and Agricultural Immunology

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“…Factors that influence the immunomodulative activities of LAB: a) a wide difference in the ability of LAB to influence the immune system (Perdigón and Alvarez, 1992;De Petrino et al, 1995;Paubert-Braquet et al, 1995) b) the effect of LAB on the immune system depends on the dose (Kishi et al, 1996) c) live cultures are more efficient in some aspects of immune stimulation compared with dead bacteria (Portier et al, 1993;Vesely et al, 1995) d) LAB applied in fermented products induce higher responses compared with cells applied in non-fermented products (Perdigón et al, 1986;Saucier et al, 1992) Other factors that could influence the efficiency of LAB by stimulation of immunity are probably the age of the host, the physiological status of the host, and the quality and quantity of feeding.…”

Section: Stimulation Of the Immune System Induced By Lactic Acid Bactmentioning

confidence: 99%

Lactic acid bacteria, probiotics and immune system

Herich¹,

Levkut²

2002

Vet. Med. - Czech

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Mucous membranes of the body are in direct contact with the outside environment and they are colonised by a large number of different bacteria. Through mucous membranes, the organism is in permanent con-tact with different antigens. Mucous surfaces are protected by many defence mechanisms that ensure a permanent and effective protection. They include the production of secretory IgA, the production of mucus, cytoprotective peptides, defensins etc. Indigenous microflora markedly affects the structure of the host mucous, its function, and the development of the whole immune system. Protective microflora prevents pathogens from adhering by competi-tion for substrates and places of adhesion, and they simultaneously produce antibacterial substances and stimulate the production of specific antibodies and mucus. The early colonisation of the gut with living micro-organisms is important for the development of the gut protection barrier. The number of immune and epithelial cells increases. Probiotic micro-organisms including lactic acid bacteria (LAB) positively influence the composition of the gut microflora; they stimulate the production of secretory IgA; they affect the targeted transportation of the luminal antigens to Peyer’s patches and they increase the production of IFN-g. LAB stimulate the activity of non-specific and specific immune cells. These properties of the LAB depend on the particular species or strain of bacteria. These singularities are probably determined by differences in the cell wall composition. LAB belong to a group of benefi-cially acting bacteria and they are able to eliminate damage to the gut microenvironment; they stimulate local and systemic immune responses and they maintain the integrity of the gut wall.

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Effect of the oral administration of Lactobacillus brevis subsp. coagulans on interferon-alpha producing capacity in humans.

Cited by 87 publications

References 31 publications

Enhancing immunity by dietary consumption of a probiotic lactic acid bacterium (Bifidobacterium lactis HN019): optimization and definition of cellular immune responses

Enhancing immunity by dietary consumption of a probiotic lactic acid bacterium (Bifidobacterium lactis HN019): optimization and definition of cellular immune responses

The Influence of Short-term and Continuous Administration of Lactobacillus casei on Basic Haematological and Immunological Parameters in Gnotobiotic Piglets

Lactic acid bacteria, probiotics and immune system

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