Effect of the opiate antagonist naloxone on body temperature in rats

Goldstein, Avram; Lowery, Patricia J.

doi:10.1016/0024-3205(75)90445-2

Cited by 91 publications

(14 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This agrees with the reports of Lal, Reddy & Drawbaugh (1973) and Goldstein & Lowery (1975). However, in morphine dependent rats naloxone produced a consistent hypothermic response with falls in body temperature of up to a maximum of 1.1"C. This finding agrees with the observations of Martin et al (1963), Schwartz & Eidelberg (1970), La1 et al (1973 and Hosoya (1975), all of whom have reported hypothermic responses in the rat on withdrawal of morphine.…”

Section: Brain Aminessupporting

confidence: 94%

Physical Dependence in the Rat Induced by Slow Release Morphine: Dose-Response, Time Course and Brain Biogenic Amines

Laska

Fennessy

1976

Clin Exp Pharmacol Physiol

View full text Add to dashboard Cite

1. Physical dependence was induced in rats by administration of a slow release morphine emulsion (morphine SR), and assessed by scoring abstinence signs and temperature changes after i.p. administration of naloxone (5 mg/kg). Three groups of rats received doses of 75, 100 or 150 mg/kg of morphine SR. Dependence was evaluated in each of these groups after 24, 48 and 72 h. 2. The effect of these treatments at the different times on brain levels of serotonin, 5-hydroxyindoleacetic acid, noradrenaline and dopamine was determined. 3. A ceiling level of dependence was reached 24 h after 75 and 100 mg/kg and 48 h after 150 mg/kg of morphine SR. 4. These different treatments produced no significant effect on the brain levels of noradrenaline, dopamine or serotonin. The levels of 5-hydroxyindoleacetic acid were significantly raised in morphine-dependent rats and the changes correlated well with the changes in abstinence behaviour and temperature after naloxone. 5. The results suggest that a relationship exists between serotonin turnover and physical dependence on morphine.

show abstract

Section: Brain Aminessupporting

confidence: 94%

Physical Dependence in the Rat Induced by Slow Release Morphine: Dose-Response, Time Course and Brain Biogenic Amines

Laska

Fennessy

1976

Clin Exp Pharmacol Physiol

View full text Add to dashboard Cite

show abstract

“…However, Goldstein and Lowery demonstrated no effect of naloxone in coldexposed rats (20,16 hr; table 1 of ref. 9). By contrast, we found a profound hyperthermia in response to naloxone injections in acutely and chronically heated rats (Figs.…”

Section: Discussionmentioning

confidence: 44%

“…Goldstein and Lowery (9) were unable to show an effect of naloxone on animals subjected to cold stress; however, Lal and coworkers (10) were able to reverse conditioned hyperthermia with naloxone.…”

mentioning

confidence: 99%

Endorphins may function in heat adaptation.

Holaday¹,

Wei²,

Loh³

et al. 1978

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

Administration of the opiate antagonist naloxone to rats after acute or chronic heat exposure precipitates an increase in colonic temperature, an increase in escape attempts, and a decrease in body weight. These changes are accompanied by signs associated with hyperthermia such as salivation, diarrhea, and an abnormal extended posture. Although brain endorphin involvement is possible, hypophysectomy diminishes the intensity and magnitude of these naloxone effects, indicating that the naloxone effect in intact animals may be due to a functional antagonism of pituitary endorphins. These observations suggest that endorphins attenuate physiological responses to thermal and noxious stimuli triggered in common neuroanatomical pathways by heat.

show abstract

“…Mild and strong stressors also affect body temperature [6,7,15,29,39] and, accord ingly, in our study hyperthermia was ob served in rats, both shocked or exposed to the unelectrified grid and even in rats that were simply saline-injected and tested for body temperature. CATH has been found to induce a hyperthermic response in rabbits [22], and in the present experiment it en hanced the hyperthermic response to the ex perimental procedure.…”

Section: Discussionmentioning

confidence: 78%

Brief Footshock Analgesia: Long-Lasting Enhancement Induced by Cathinone, an Amphetamine-Like Agent

Nencini¹,

Anania²,

Moscucci³

et al. 1988

Pharmacology

View full text Add to dashboard Cite

In view of the analgesic effects produced by cathinone (CATH), an amphetamine-like agent, and of the interaction of amphetamines with stressful environmental stimuli, the present study evaluated in rats the influence of CATH on the nonopioid analgesia induced by a brief electric footshock (FSA; 3 min of continuous 2.5 mA current). The influence of this combination on body temperature was also evaluated. CATH (5 mg/kg, i.p.) alone induced a brief and slight increase in latency during the hot plate test (HPT), but enhanced and prolonged the analgesic effect induced by FS. In addition, the presentation of the environment (shock box with unelectrified grid) where other rats received FS, caused CATH to induce a slow-rising analgesic effect for 180 min. A hyperthermic response paralleling the analgesic effect was observed in shocked and nonshocked rats receiving CATH. After 24 h, rats that had received both CATH and FS on the previous day showed prolonged latencies on the HPT before and after a 1-min presentation of unelectrified grid. These animals also showed an increased analgesic response to the subsequent application of a 15-second FS. At the same time no differences in body temperature were observed between treatment groups. These results suggest that CATH can interact with environmental stimuli to induce an analgesic effect, the time-course of which depends upon the intensity of the stimulus applied.

show abstract

Effect of the opiate antagonist naloxone on body temperature in rats

Cited by 91 publications

References 9 publications

Physical Dependence in the Rat Induced by Slow Release Morphine: Dose-Response, Time Course and Brain Biogenic Amines

Physical Dependence in the Rat Induced by Slow Release Morphine: Dose-Response, Time Course and Brain Biogenic Amines

Endorphins may function in heat adaptation.

Brief Footshock Analgesia: Long-Lasting Enhancement Induced by Cathinone, an Amphetamine-Like Agent

Contact Info

Product

Resources

About