Effect of the new SARS-CoV-2 variant B.1.1.7 on children and young people

Brookman, Sarah; Cook, James; Zucherman, Mark; Broughton, Simon; Harman, Katharine; Gupta, Atul

doi:10.1016/s2352-4642(21)00030-4

Cited by 106 publications

(96 citation statements)

References 3 publications

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“…Our finding of lower age specific hazard ratio estimates in younger age groups are consistent with a previously reported age specific adjusted odds ratio of hospital admission of 1.0 for patients aged 0-19 with versus without SGTF variants in seven EU/EEA countries but contrasts with a study in Denmark that reported an adjusted odds ratio of 1.84 for patients aged 0-29 with SGTF variants. 23 24 Children and adolescents aged ≤18 who were admitted to hospital with covid-19 in November 2020 to January 2021 at King’s College Hospital in London (where the local prevalence of B.1.1.7 was high) were reported to have had similar clinical severity and treatment requirements to those admitted in March to May 2020, 25 corroborating the suggestion that patients in the youngest age groups experience no more severe disease if infected with B.1.1.7 than with wild-type SARS-CoV-2.…”

Section: Discussionmentioning

confidence: 99%

Risk of hospital admission for patients with SARS-CoV-2 variant B.1.1.7: cohort analysis

Nyberg

Twohig

Harris

et al. 2021

BMJ

137

114

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Objective To evaluate the relation between diagnosis of covid-19 with SARS-CoV-2 variant B.1.1.7 (also known as variant of concern 202012/01) and the risk of hospital admission compared with diagnosis with wild-type SARS-CoV-2 variants. Design Retrospective cohort analysis. Setting Community based SARS-CoV-2 testing in England, individually linked with hospital admission data. Participants 839 278 patients with laboratory confirmed covid-19, of whom 36 233 had been admitted to hospital within 14 days, tested between 23 November 2020 and 31 January 2021 and analysed at a laboratory with an available TaqPath assay that enables assessment of S-gene target failure (SGTF), a proxy test for the B.1.1.7 variant. Patient data were stratified by age, sex, ethnicity, deprivation, region of residence, and date of positive test. Main outcome measures Hospital admission between one and 14 days after the first positive SARS-CoV-2 test. Results 27 710 (4.7%) of 592 409 patients with SGTF variants and 8523 (3.5%) of 246 869 patients without SGTF variants had been admitted to hospital within one to 14 days. The stratum adjusted hazard ratio of hospital admission was 1.52 (95% confidence interval 1.47 to 1.57) for patients with covid-19 infected with SGTF variants, compared with those infected with non-SGTF variants. The effect was modified by age (P<0.001), with hazard ratios of 0.93-1.21 in patients younger than 20 years with versus without SGTF variants, 1.29 in those aged 20-29, and 1.45-1.65 in those aged ≥30 years. The adjusted absolute risk of hospital admission within 14 days was 4.7% (95% confidence interval 4.6% to 4.7%) for patients with SGTF variants and 3.5% (3.4% to 3.5%) for those with non-SGTF variants. Conclusions The results suggest that the risk of hospital admission is higher for people infected with the B.1.1.7 variant compared with wild-type SARS-CoV-2, likely reflecting a more severe disease. The higher severity may be specific to adults older than 30 years.

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Section: Discussionmentioning

confidence: 99%

Risk of hospital admission for patients with SARS-CoV-2 variant B.1.1.7: cohort analysis

Nyberg

Twohig

Harris

et al. 2021

BMJ

137

114

View full text Add to dashboard Cite

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“…Since March 2020, most governments around the world have closed schools and other educational institutions in an attempt to contain the diffusion of the COVID-19 pandemic, with an estimated dramatic impact on the education of over 850 million children and youths [1][2][3][4]. On the other hand, epidemiological data show that people aged 1-18 years tend to develop asymptomatic/paucisymptomatic disease, and, overall, present a significantly more favorable outcome than adults [5][6][7]. Furthermore, younger children seem to be less susceptible to infection and transmitting the disease compared to older children, adolescents, and adults [3,5].…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, younger children seem to be less susceptible to infection and transmitting the disease compared to older children, adolescents, and adults [3,5]. However, with the emergence of new variants, the risk of disease transmission and outcomes in children deserve close surveillance [5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Would Parents Get Their Children Vaccinated Against SARS-CoV-2? Rate and Predictors of Vaccine Hesitancy According to a Survey over 5000 Families from Bologna, Italy

et al. 2021

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In the near future, COVID-19 vaccine efficacy trials in larger cohorts may offer the possibility to implement child and adolescent vaccination. The opening of the vaccination for these strata may play a key role in order to limit virus circulation, infection spreading towards the most vulnerable subjects, and plan safe school reopening. Vaccine hesitancy (VH) could limit the ability to reach the coverage threshold required to ensure herd immunity. The aim of this study was to investigate the prevalence and determinants of VH among parents/guardians toward a potentially available COVID-19 vaccination for children and adolescents. An online survey was performed in parents/guardians of children aged <18 years old, living in Bologna. Overall, 5054 questionnaires were collected. A vast majority (60.4%) of the parents/guardians were inclined to vaccinate, while 29.6% were still considering the opportunity, and 9.9% were hesitant. Highest vaccine hesitancy rates were detected in female parents/guardians of children aged 6–10 years, ≤29 years old, with low educational level, relying on information found in the web/social media, and disliking mandatory vaccination policies. Although preliminary, these data could help in designing target strategies to implement adherence to a vaccination campaign, with special regard to web-based information.

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“…Another UK based study of a cohort of 198,420 patients reported an increase in disease severity, critical care admission and 60% increased risk of mortality associated with B.1.1.7 [ 33 ]. An increase in the pediatric cases with COVID-19 in the UK during the second wave of the pandemic is attributed to B.1.1.7 prevalence and high transmission nonetheless, no significant increase in morbidity or mortality on these young individuals were observed [ 34 ]. Pertaining to vaccine efficacy, despite being 45% more transmissible, prioritized vaccination with an mRNA vaccine coupled with proactive surveillance programs was shown to prevent B.1.1.7 infections especially in the elderly [ 35 ].…”

Section: B117: ‘Uk Variant’mentioning

confidence: 99%

COVID-19: Structural Considerations for Virus Pathogenesis, Therapeutic Strategies and Vaccine Design in the Novel SARS-CoV-2 Variants Era

Volkan

2021

Mol Biotechnol

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COVID-19 pandemic caused by SARS-CoV-2 globally impacted the humanity causing tragic outcomes; costing millions of lives, destroying economies and demolishing public health infrastructures. The emergence of vaccines using various ingenious approaches in less than a year was deemed the light at the end of the tunnel. However, recent emergence of variants of SARS-CoV-2 in several parts of the world revealed that another hurdle is ahead in the fight against COVID-19. This review will highlight how SARS-CoV-2 mutations, creating different virus variants could potentially impact virus pathogenesis as well as different therapy approaches and vaccine design.

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Effect of the new SARS-CoV-2 variant B.1.1.7 on children and young people

Cited by 106 publications

References 3 publications

Risk of hospital admission for patients with SARS-CoV-2 variant B.1.1.7: cohort analysis

Risk of hospital admission for patients with SARS-CoV-2 variant B.1.1.7: cohort analysis

Would Parents Get Their Children Vaccinated Against SARS-CoV-2? Rate and Predictors of Vaccine Hesitancy According to a Survey over 5000 Families from Bologna, Italy

COVID-19: Structural Considerations for Virus Pathogenesis, Therapeutic Strategies and Vaccine Design in the Novel SARS-CoV-2 Variants Era

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