Effect of the nervous system on cancer: Analysis of clinical studies

Mravec, Boris; Dubravicky, J.; Tibenský, Miroslav; Horváthová, Ľubica

doi:10.4149/bll_2019_019

Cited by 3 publications

(3 citation statements)

References 51 publications

(58 reference statements)

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“…Secondly, in our series, no patient affected only by non-secreting parasympathetic lesion (HNPGL) developed a second malignant tumor. This result is in line with previous studies showing the role of catecholamines in tumorigenesis [ 39 , 40 ]. Interestingly, this data could also explain why patients belonging to cluster 1 are less affected by second malignant tumors.…”

Section: Discussionsupporting

confidence: 93%

A Multicenter Epidemiological Study on Second Malignancy in Non-Syndromic Pheochromocytoma/Paraganglioma Patients in Italy

Canu

Puglisi

Berchialla

et al. 2021

Cancers

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No studies have carried out an extensive analysis of the possible association between non-syndromic pheochromocytomas and paragangliomas (PPGLs) and other malignancies. To assess >the risk of additional malignancy in PPGL, we retrospectively evaluated 741 patients with PPGLs followed-up in twelve referral centers in Italy. Incidence of second malignant tumors was compared between this cohort and Italian patients with two subsequent malignancies. Among our patients, 95 (12.8%) developed a second malignant tumor, which were mainly prostate, colorectal and lung/bronchial cancers in males, breast cancer, differentiated thyroid cancer and melanoma in females. The standardized incidence ratio was 9.59 (95% CI 5.46–15.71) in males and 13.21 (95% CI 7.52–21.63) in females. At multivariable analysis, the risk of developing a second malignant tumor increased with age at diagnosis (HR 2.50, 95% CI 1.15–5.44, p = 0.021 for 50–59 vs. <50-year category; HR 3.46, 95% CI 1.67–7.15, p < 0.001 for >60- vs. <50-year). In patients with available genetic evaluation, a positive genetic test was inversely associated with the risk of developing a second tumor (HR 0.25, 95% CI 0.10–0.63, p = 0.003). In conclusion, PPGLs patients have higher incidence of additional malignant tumors compared to the general population who had a first malignancy, which could have an impact on the surveillance strategy.

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Section: Discussionsupporting

confidence: 93%

A Multicenter Epidemiological Study on Second Malignancy in Non-Syndromic Pheochromocytoma/Paraganglioma Patients in Italy

Canu

Puglisi

Berchialla

et al. 2021

Cancers

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“…Apart from previously mentioned biomarkers, considerable effort is put into researching all the elements that have some impact on tumorigenesis, progression and recurrence. Nervous system and alterations to signalization between the nervous system and peripheral tissue have also been reported in association to initiation and cancer progression (30).…”

Section: Discussionmentioning

confidence: 99%

The prognostic value of E-cadherin and Ki-67 compared to standard histopathologic examination in non–muscle invasive bladder cancer

Harsanyi¹,

Žiaran²,

Bevizova³

et al. 2020

BLL

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OBJECTIVES: The objectives of this study were to determine the prognostic value of expression levels of selected biomarkers and their statistical analysis in relation to survival and standard histopathologic examination and other clinicopathologic variables in non-muscle invasive bladder cancer (NMIBC). BACKGROUND: Worldwide, bladder cancer is a frequent malignant disease with rising incidence. Characteristic invasiveness and high recurrence rates call for more diagnostic methods to obtain more accurate information. Prognosis is affected by a signifi cant interpersonal variability of the disease. For this reason, constant search for alternative and better diagnostic methods is essential. METHODS: We analysed cancer tissue from patients with Ta and T1 bladder cancer. E-cadherin and Ki-67 expression levels were analysed using immunohistochemical staining. The expression levels quantifi ed to a percentual amount were statistically analysed in relation to survival and their frequency distribution in the study group. RESULTS: E-cadherin and Ki-67 expression levels show high association with tumor stage and grade (p<0.001), in contrast, the association with recurrence has proven insignifi cant. Patients with non-aberrant biomarker expression levels have much higher survival rates than the cases with aberrant expression. CONCLUSION: Low expression levels of Ki-67 and high expression levels of E-cadherin positively affect survival of patients, whereas aberrant expressions pose poorer prognosis (Tab. 2, Fig. 2, Ref. 33).

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“…Tumors of glial origin are primary intracranial tumors of neuroepithelial tissues and at an advanced stage cause difficulties in the form of headache, nausea, vomiting, mental changes and cognitive impairment [26]. Although the symptomatic burden is high and the prognosis of high-grade glioma is poor, there is still a lack of supportive treatment for this disease.…”

Section: High-grade Brain Gliomamentioning

confidence: 99%

Yoga in the Life of a Cancer Patient – A Narrative Review

Obročníková¹,

Majerníková²

2021

hpc

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Authors' contributionWkład autorów: A. Study design/planning zaplanowanie badań B. Data collection/entry zebranie danych C. Data analysis/statistics dane -analiza i statystyki D. Data interpretation interpretacja danych E. Preparation of manuscript przygotowanie artykułu F. Literature analysis/search wyszukiwanie i analiza literatury G. Funds collection zebranie funduszy SummaryYoga exists in the context of health care, complementary therapy, movement training techniques as well as religious philosophy. Many studies suggest yoga is a non-demanding activity that can effectively reduce anxiety, depression, and pain in the adult population with acute and chronic health conditions without adverse effects. Based on the results of numerous studies, yoga intervention can improve mental health and improve the quality of life of cancer patients or survivors. This paper focuses on yoga and its impact on alleviating the symptoms of cancer and the treatment. Based on the reviewed literature, the results of the studies suggest the problem of heterogeneous study design, lack of quantitative findings and lack of evidence regarding the long-term effects of yoga on the personal well-being of cancer patients. Future research should focus on systematic reviews or meta-analyses to provide further evidence on the type and effectiveness of yoga during or after cancer treatment for specific cancers.

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Effect of the nervous system on cancer: Analysis of clinical studies

Cited by 3 publications

References 51 publications

A Multicenter Epidemiological Study on Second Malignancy in Non-Syndromic Pheochromocytoma/Paraganglioma Patients in Italy

A Multicenter Epidemiological Study on Second Malignancy in Non-Syndromic Pheochromocytoma/Paraganglioma Patients in Italy

The prognostic value of E-cadherin and Ki-67 compared to standard histopathologic examination in non–muscle invasive bladder cancer

Yoga in the Life of a Cancer Patient – A Narrative Review

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