Effect of the Nature of Ceratophyllum demersum Extracts on Lactuca sativa Seedlings

Viveros-Legorreta, José Luis; Sarma, S. S. S.; Guerrero-Zúñiga, Leonor Angélica; Rodríguez-Dorantes, Angélica

doi:10.20546/ijcrbp.2016.307.010

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“…Van Donk and van de Bund also confirmed an increase in the biomass of chlorophytes Chlorella and Chlamydomonas growing within Ceratophyllum demersum clumps 28 . Some researchers investigated the promoting or inhibiting effects of aqueous or acetone extracts from C. demersum on root elongation, seed germination, or seedling growth in terrestrial plants 29 , 30 .…”

Section: Introductionmentioning

confidence: 99%

Ceratophyllum demersum the submerged macrophyte from the mining subsidence reservoir Nadrybie Poland as a source of anticancer agents

Masłyk,

Lenard,

Olech

et al. 2024

Sci Rep

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Aquatic plants are a rich source of health-beneficial substances. One of such organisms is the submerged macrophyte Ceratophyllum demersum, which has not been sufficiently studied in this aspect so far. In this work, we have studied environmental conditions prevailing in a subsidence mining reservoir in Eastern Poland and shown that C. demersum can be harvested for further analysis even from artificial anthropogenic reservoirs. The phytochemical analysis of C. demersum ethanolic extract using LC–MS revealed high content of phenolic compounds (18.50 mg/g) (mainly flavonoids, 16.09 mg/g), including those that have not yet been identified in this plant, namely isorhamnetin, sakuranetin, taxifolin, and eriodictyol. Such rich flavonoid content is most likely responsible for the anticancer activity of the C. demersum extract, which was targeted especially at neoplastic cells of gastrointestinal tract origin. The flow cytometry analysis of treated cells showed an increased percentage of late apoptotic and necrotic cells. The fish embryo toxicity (FET) test showed safety of the extract towards Danio rerio fish up to the concentration of 225 µg/ml. This study has shown that the submerged macrophyte Ceratophyllum demersum can be taken into consideration as a rich source of a set of anticancer agents with chemopreventive potential.

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Section: Introductionmentioning

confidence: 99%