Effect of the Molecularly Imprinted Polymer Component Ratio on Analytical Performance

Pratama, Kelvin Fernando; Manik, Maretty; Rahayu, Driyanti; Hasanah, Aliya Nur

doi:10.1248/cpb.c20-00551

Cited by 35 publications

(22 citation statements)

References 70 publications

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“…The template/monomer/crosslinker molar ratio is most frequently 1:4:20. This ratio is probable to provide optimum imprinting efficiency [66] and in the most cases the mentioned value of the molecular ratio is confirmed by the results of computer molecular modelling. The proportion of reagents is very important in non-covalent imprinting as it requires the presence of template-monomer complexes.…”

Section: The Greenness Assessment Of Mi-spe Technique For Pesticide Determinationsupporting

confidence: 53%

Multivariate Assessment of Procedures for Molecularly Imprinted Polymer Synthesis for Pesticides Determination in Environmental and Agricultural Samples

2021

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In the case of quantitative and qualitative analysis of pesticides in environmental and food samples, it is required to perform a sample pre-treatment process. It allows to minimalize the impact of interferences on the final results, as well as increase the recovery rate. Nowadays, apart from routinely employed sample preparation techniques such as solid-phase extraction (SPE) or solid-phase microextraction (SPME), the application of molecularly imprinted polymers (MIPs) is gaining greater popularity. It is mainly related to their physicochemical properties, sorption capacity and selectivity, thermo-mechanical resistance, as well as a wide range of polymerization techniques allowing to obtain the desired type of sorption materials, adequate to a specific type of pesticide. This paper targets to summarize the most popular and innovative strategies since 2010, associated with the MIPs synthesis and analytical procedures for pesticides determination in environmental and food samples. Application of multi-criteria decision analysis (MCDA) allows for visualization of the most beneficial analytical procedures in case of changing the priority of each step of analysis (MIPs synthesis, sample preparation process—pesticides extraction, chromatographic analysis) bearing in mind metrological and environmental issues.

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Section: The Greenness Assessment Of Mi-spe Technique For Pesticide Determinationsupporting

confidence: 53%

Multivariate Assessment of Procedures for Molecularly Imprinted Polymer Synthesis for Pesticides Determination in Environmental and Agricultural Samples

2021

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“…The following ratios were used for this synthesis: the template: monomer:crosslinker ratio for MIP1 and MIP3 was 1:6:20, while for MIP2 and MIP 4 it was 1:4:20. MIP1 and MIP3 used the ratio from the computational approach and Jobs results, while MIP 2 and MIP 4 used the ratio from the study of Pratama et al, 37 which demonstrated that the use of template-monomer (1:4) provides an excellent specific affinity and high recovery of template compound compared with NIP sorbents. The bulk method was used for the synthesis of MIPs and NIPs.…”

Section: Preparation Of the Mip And Nipmentioning

confidence: 99%

Rational design of salmeterol xinafoate imprinted polymer through computational method: Functional monomer and crosslinker selection

Suryana

Mutakin

Rosandi

et al. 2021

Polymers for Advanced Techs

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A molecular imprinted polymer (MIP) was computationally designed and synthesized for the selective extraction of salmeterol xinafoate (SLX) from human serum. In this study, semi-empirical PM3 calculations were used to find a suitable functional monomer (FM), the ratio of template (T) to FM, and types of crosslinkers. MIPs were synthesized with 2-hydroxyethyl methacrylate (HEMA) with T:FM mol ratios of 1:6 and 1:4 and ethylene glycol dimethacrylate (EGDMA) or trimethylolpropane trimethacrylate (TRIM) as a crosslinker. On the basis of computational and experimental results, HEMA and TRIM in the mol ratio 1:6 of T-FM (MIP3) were found to be the best choices of FM and crosslinker, respectively. These polymers were then used as a selective sorbent to develop a molecularly imprinted solid-phase extraction procedure followed by high performance liquid chromatography with UV detection for the determination of SLX in serum. The extraction ability of MIP3 was excellent with a recovery of 92.17% ± 2.66% of SLX in spiked serum, and 91.15% ± 1.12% when SLX was spiked as a mixture with another analogous structure. By comparing the performance of the synthesized sorbent with a C-18 cartridge with a recovery of 79.11% ± 2.96%, it was determined that MIP had better performance over the latter. On the basis of these results, the imprinted receptor MIPs, especially MIP 3, can be applied for the direct extraction of SLX in clinical analysis.

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“…The emphasis on monomer-template ratio here is a product of standard imprinting theory, in that affinity and selectivity are presumed to derive from the interaction of multiple polymer functionalities in the binding site [ 179 , 180 ]. Multiple studies suggest the optimal functional monomer-template ratio is 4:1 for most applications [ 164 , 179 , 181 ]. This does not include the crosslinker, which is often the major component of the polymer.…”

Section: Introductionmentioning

confidence: 99%

Template Imprinting Versus Porogen Imprinting of Small Molecules: A Review of Molecularly Imprinted Polymers in Gas Sensing

Cowen

Cheffena

2022

IJMS

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The selective sensing of gaseous target molecules is a challenge to analytical chemistry. Selectivity may be achieved in liquids by several different methods, but many of these are not suitable for gas-phase analysis. In this review, we will focus on molecular imprinting and its application in selective binding of volatile organic compounds and atmospheric pollutants in the gas phase. The vast majority of indexed publications describing molecularly imprinted polymers for gas sensors and vapour monitors have been analysed and categorised. Specific attention was then given to sensitivity, selectivity, and the challenges of imprinting these small volatile compounds. A distinction was made between porogen (solvent) imprinting and template imprinting for the discussion of different synthetic techniques, and the suitability of each to different applications. We conclude that porogen imprinting, synthesis in an excess of template, has great potential in gas capture technology and possibly in tandem with more typical template imprinting, but that the latter generally remains preferable for selective and sensitive detection of gaseous molecules. More generally, it is concluded that gas-phase applications of MIPs are an established science, capable of great selectivity and parts-per-trillion sensitivity. Improvements in the fields are likely to emerge by deviating from standards developed for MIP in liquids, but original methodologies generating exceptional results are already present in the literature.

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Effect of the Molecularly Imprinted Polymer Component Ratio on Analytical Performance

Cited by 35 publications

References 70 publications

Multivariate Assessment of Procedures for Molecularly Imprinted Polymer Synthesis for Pesticides Determination in Environmental and Agricultural Samples

Multivariate Assessment of Procedures for Molecularly Imprinted Polymer Synthesis for Pesticides Determination in Environmental and Agricultural Samples

Rational design of salmeterol xinafoate imprinted polymer through computational method: Functional monomer and crosslinker selection

Template Imprinting Versus Porogen Imprinting of Small Molecules: A Review of Molecularly Imprinted Polymers in Gas Sensing

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