Effect of the Molecular Weights of Poly‐<scp>L</scp>‐Arginine on Membrane Strength and Permeability of Poly‐<scp>L</scp>‐Arginine Group Microcapsules

Wang, Shibin; Liu, Yuangang; Weng, Lian-Jin; Ma, Xiaojun

doi:10.1002/mabi.200350005

Cited by 10 publications

(7 citation statements)

References 6 publications

(6 reference statements)

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“…The effects of the reaction solvents, monomer concentration, and acid acceptors on the molecular weight of the resulting Arg‐PEA polymers were investigated. The combined characteristics of aqueous solubility and positive charge in Arg‐PEAs along with the reported study that Arg‐based polymers could enter cells more efficiently than other polycationic homopolymers36 could provide great potentials as transfection agents for the negatively charged nuclear acids like plasmid DNA and siRNA via electrostatic interaction. A preliminary study of using Arg‐PEAs to capture plasmid DNA was conducted to demonstrate the potential of such an application.…”

Section: Introductionmentioning

confidence: 94%

Synthesis and characterization of a new family of cationic amino acid‐based poly(ester amide)s and their biological properties

Song¹,

Chu²

2011

J of Applied Polymer Sci

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A new family of positively charged and water soluble amino acid-based poly(ester amide)s (PEAs) consisting of nontoxic L-arginine, diols, and aliphatic dicarboxylic acids building blocks was synthesized and characterized. The L-arginine based PEAs (Arg-PEAs) were prepared by a solution polycondensation of two monomers: tetra-p-toluenesulfonic acids salts or hydrochloride acid salts of bis-(L-arginine) a, x-alkylene diesters (monomer II), and di-p-nitrophenyl esters of saturated or unsaturated dicarboxylic acids (monomer I). Optimal reaction conditions were studied as functions of type of solvents and acid acceptors, concentrations of reactants. The molecular weights (M n and M w ) of Arg-PEAs measured by GPC ranged from 20,000 to 60,000 g mol À1 with a rather narrow molecular weight distribution below 1.5. The chemical structures were confirmed by IR and NMR spectra. ArgPEAs obtained were all amorphous materials with T g from 33 to 125 C, depending on the number and the type (saturated vs. unsaturated) of methylene groups in diols or diacids, and the type of counter-ions attached to the guanidine group of the Arg-based PEAs. The Arg-PEAs had a high solubility in all polar solvents, including water. Preliminary studies of cell morphology and DNA capture capability of Arg-PEAs indicated that this new family of cationic PEAs was nontoxic and more biocompatible than a commercial transfection agent (Superfect V R ), and can successfully capture plasma DNA. The strong positive charge of Arg-PEAs as well as their good water solubility could provide unique characteristics for potential gene transfection or other charge preferred biomedical applications.

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Section: Introductionmentioning

confidence: 94%

Synthesis and characterization of a new family of cationic amino acid‐based poly(ester amide)s and their biological properties

Song¹,

Chu²

2011

J of Applied Polymer Sci

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“…However, the low membrane strength of poly-L-arginine group microcapsules has limited their application and development. [8] In the present work, we attempted to prepare alginate/poly-Larginine/chitosan ternary complex microcapsules in order to enhance the membrane strength, mucosal adhesion and intervening therapeutic efficacy of microcapsules. The effect of drug-loading methods on drug load, the encapsulation efficiency and the release properties of the complex microcapsules were investigated.…”

Section: Introductionmentioning

confidence: 99%

Effect of Drug‐loading Methods on Drug Load, Encapsulation Efficiency and Release Properties of Alginate/Poly‐L‐Arginine/Chitosan Ternary Complex Microcapsules

Wang

Chen

Weng

et al. 2004

Macromolecular Bioscience

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The drug-loaded alginate/poly-L-arginine/chitosan ternary complex microcapsules were prepared by mixing method, absorption method and the combined method of mixing and absorption, respectively. The effect of drug-loading methods on drug load, the encapsulation efficiency and the release properties of the complex microcapsules were investigated. The results showed that the absorption process is a dominating factor to greatly increase the drug load of Hb into microcapsules. Upon loading Hb into microcapsules by combined method of mixing and absorption, the drug load (19.9%) is up to the maximum value, and the encapsulation efficiency is 93.8%. Moreover, the drug release is a zero-order kinetics process for the ternary complex microcapsules made by mixing. For the complex microcapsules made by absorption, the drug release is a first-order kinetics. However, for the complex microcapsules made by combining the mixing and the absorption, the drug release obeys a first-order kinetics during the first eighteen hours, changing afterwards to a zero-order kinetics process. Effect of drug-loading methods on drug load and encapsulation efficiency of alginate/poly-L-arginine/chitosan ternary complex microcapsules.

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“…The particles produced can, therefore, be characterized as microparticles, since the spectrum of sizes for microparticles varies between 1 and 1000 µm [18,19]. According to Wang et al [20], the concentration of sodium alginate may influence the particle shape and, usually, a mass concentration of sodium alginate between 0.8 and 1.5% is used to produce microparticles. These authors also consider that, when the percentage of sodium alginate is higher than the values cited the particles may present an oval shape.…”

Section: Sem Analysesmentioning

confidence: 99%

Development and Characterization of a Gel Formulation Integrating Microencapsulated Nitrofurazone

Balcão¹,

Santos²,

Martins

et al. 2014

CPB

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Nitrofurazone (NTZ) is usually employed in the topical treatment of infected wounds and lesions of both skin and mucosa. Microencapsulation is a process utilized in the incorporation of active ingredients within polymers aiming at, among other objectives, the prolonged release of pharmaceutical compounds and protection from atmospheric agents (viz. moisture, light, heat and/or oxidation). With the goal of utilizing the microparticles containing encapsulated NTZ in pharmaceutical formulations, one prepared microparticles containing NTZ via ionotropic gelation of sodium alginate. The microparticles were characterized via scanning electron microscopy analyses, Fourier transform infrared spectroscopy (FTIR) analyses, via determination of encapsulation efficiency, and via thermal analyses (both TGA and DSC). The final gel formulation was also characterized rheologically. The extrusion/solidification technique employed to obtain the calcium alginate microparticles with encapsulated NTZ was found to be adequate, and produced an NTZ encapsulation efficiency of ca. 97.8% ± 1.1%. The calcium alginate microparticles thus obtained, with encapsulated NTZ, exhibited an oval shape and hydrodynamic diameters between 500 μm and 800 μm. From the thermal analyses performed, together with information from the infrared spectra, one may conclude that NTZ did not strongly bind to the polymer, which may be favorable for the release of the active ingredient. From the results obtained in the present research effort, one may conclude that the microparticles produced possess the potential to be utilized as carriers for NTZ in pharmaceutical formulations such as gels, ointments, and solutions.

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Effect of the Molecular Weights of Poly‐L‐Arginine on Membrane Strength and Permeability of Poly‐L‐Arginine Group Microcapsules

Cited by 10 publications

References 6 publications

Synthesis and characterization of a new family of cationic amino acid‐based poly(ester amide)s and their biological properties

Synthesis and characterization of a new family of cationic amino acid‐based poly(ester amide)s and their biological properties

Effect of Drug‐loading Methods on Drug Load, Encapsulation Efficiency and Release Properties of Alginate/Poly‐L‐Arginine/Chitosan Ternary Complex Microcapsules

Development and Characterization of a Gel Formulation Integrating Microencapsulated Nitrofurazone

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