“…The formation of amide bonds between PVCL-COOH and chitosan amino groups has been confirmed by FTIR [78,80,85], 1 H-NMR [78,85] and Raman [85] spectroscopy techniques. EDC/NHS system is the activator agent usually used by many authors.…”
Section: Synthesismentioning
confidence: 87%
“…After this pioneering work, the synthesis of the chitosan-graft-PVCL by the grafting onto approach has been documented by other authors [79][80][81][82][83][84][85]. The formation of amide bonds between PVCL-COOH and chitosan amino groups has been confirmed by FTIR [78,80,85], 1 H-NMR [78,85] and Raman [85] spectroscopy techniques.…”
Section: Synthesismentioning
confidence: 89%
“…The phase transition behaviour of Cs-g-PVCL in aqueous solutions has been investigated by turbidimetry [78][79][80]85], DSC [79,85] and DLS [96]. The LCST of this copolymer has been estimated between 32 and 42 °C, and it was close to the transition of the corresponding homopolymers.…”
Section: Propertiesmentioning
confidence: 98%
“…In this sense, our group has reported the synthesis of PVCL-COOH samples with different molecular weights by means of controlled radical polymerization and their subsequent grafting onto the chitosan backbone using DMTMM as activator agent. This approach allows a control of the chain length of the grafted PVCL chains, as well as the spacing between grafted side chains onto the chitosan backbone [85].…”
Section: Synthesismentioning
confidence: 99%
“…These parameters have been evaluated by 1 H-NMR [78], thermogravimetric analysis (TGA) [85] and gravimetrically [79,85,90].…”
Thermosensitive polymers are materials capable of undergoing a reversible phase transition in aqueous media in response to a variation of the temperature. They have attracted high scientific interest for advanced applications in diverse areas, such as biotechnology, biomedical, environmental, food industry and other fields. At the same time, chitosan is a promising marine polysaccharide that has long been used in applications such as drug, peptide or gene delivery systems. Being the most abundant marine polysaccharide, chitin and chitosan do not exhibit thermoresponsive properties, but some of their derivatives do. In the present chapter, the efforts to produce chitosan-based thermosensitive materials are reviewed. Particularly, the properties and applications of chitosan-glycerophosphate thermogelling system are examined; the methods of synthesis of chitosan copolymers grafted with poly(Nisopropylacrylamide) or poly(N-vinylcaprolactam), their physicochemical properties and most of their prominent applications are discussed as well.
“…The formation of amide bonds between PVCL-COOH and chitosan amino groups has been confirmed by FTIR [78,80,85], 1 H-NMR [78,85] and Raman [85] spectroscopy techniques. EDC/NHS system is the activator agent usually used by many authors.…”
Section: Synthesismentioning
confidence: 87%
“…After this pioneering work, the synthesis of the chitosan-graft-PVCL by the grafting onto approach has been documented by other authors [79][80][81][82][83][84][85]. The formation of amide bonds between PVCL-COOH and chitosan amino groups has been confirmed by FTIR [78,80,85], 1 H-NMR [78,85] and Raman [85] spectroscopy techniques.…”
Section: Synthesismentioning
confidence: 89%
“…The phase transition behaviour of Cs-g-PVCL in aqueous solutions has been investigated by turbidimetry [78][79][80]85], DSC [79,85] and DLS [96]. The LCST of this copolymer has been estimated between 32 and 42 °C, and it was close to the transition of the corresponding homopolymers.…”
Section: Propertiesmentioning
confidence: 98%
“…In this sense, our group has reported the synthesis of PVCL-COOH samples with different molecular weights by means of controlled radical polymerization and their subsequent grafting onto the chitosan backbone using DMTMM as activator agent. This approach allows a control of the chain length of the grafted PVCL chains, as well as the spacing between grafted side chains onto the chitosan backbone [85].…”
Section: Synthesismentioning
confidence: 99%
“…These parameters have been evaluated by 1 H-NMR [78], thermogravimetric analysis (TGA) [85] and gravimetrically [79,85,90].…”
Thermosensitive polymers are materials capable of undergoing a reversible phase transition in aqueous media in response to a variation of the temperature. They have attracted high scientific interest for advanced applications in diverse areas, such as biotechnology, biomedical, environmental, food industry and other fields. At the same time, chitosan is a promising marine polysaccharide that has long been used in applications such as drug, peptide or gene delivery systems. Being the most abundant marine polysaccharide, chitin and chitosan do not exhibit thermoresponsive properties, but some of their derivatives do. In the present chapter, the efforts to produce chitosan-based thermosensitive materials are reviewed. Particularly, the properties and applications of chitosan-glycerophosphate thermogelling system are examined; the methods of synthesis of chitosan copolymers grafted with poly(Nisopropylacrylamide) or poly(N-vinylcaprolactam), their physicochemical properties and most of their prominent applications are discussed as well.
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