Effect of the molecular adsorbent recirculating system and Prometheus devices on systemic haemodynamics and vasoactive agents in patients with acute-on-chronic alcoholic liver failure

Laleman, Wim; Wilmer, Alexander; Evenepoel, Pieter; Elst, Ingrid Vander; Zeegers, Marcel; Zaman, Zahur; Verslype, Chris; Fevery, Johan; Nevens, Frederik

doi:10.1186/cc4985

Cited by 225 publications

(32 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Circumstances that call for an immediate treatment with renal replacement therapy, such as severe hyperkalemia, metabolic acidosis, and volume overload are infrequent in patients with type 1 HRS, particularly in the early stages. There are isolated reports and a small randomized study suggesting that the so-called artificial liver support systems, either the molecular adsorbents recirculating system (MARS) or Prometheus, may have beneficial effects in patients with type 1 HRS [224,225]. However, these approaches should still be considered investigational until more data are available.…”

Section: Renal Replacement Therapymentioning

confidence: 99%

EASL clinical practice guidelines on the management of ascites, spontaneous bacterial peritonitis, and hepatorenal syndrome in cirrhosis

Möller¹

2010

Journal of Hepatology

1,406

586

View full text Add to dashboard Cite

Section: Renal Replacement Therapymentioning

confidence: 99%

EASL clinical practice guidelines on the management of ascites, spontaneous bacterial peritonitis, and hepatorenal syndrome in cirrhosis

Möller¹

2010

Journal of Hepatology

1,406

586

View full text Add to dashboard Cite

“…69 Molecular Adsorbent Recirculating System (MARS) and single-pass albumin dialysis, both of which have shown benefit in acute and acuteon-chronic liver failure, have also been researched as potential therapeutic modalities in hypoxic hepatitis but with uncertain benefit. [70][71][72] To date, no liver-specific treatments have been proven to improve outcome. Furthermore, hypoxic hepatitis is not an indication for liver transplantation as the hepatic derangements are reversible with correction of the underlying disorder.…”

Section: Treatmentmentioning

confidence: 99%

“Cardiac Hepatopathy”: A Review of Liver Dysfunction in Heart Failure

Shah¹,

Sass²

2015

Liver Res Open J

View full text Add to dashboard Cite

The unique dual circulation of the liver confers relative protection against ischemic injury; however, low oxygen tension in the microcirculation (sinusoidal blood of the hepatic acinus) may render hepatocytes in zone 3 relatively vulnerable to ischemic injury and necrosis. Severe congestive heart failure is associated with two distinct forms of liver dysfunction under the umbrella term "cardiac hepatopathy". The two entities include: jaundice related to passive congestion (congestive hepatopathy from backward cardiac failure) and acute hepatocellular necrosis caused by impaired hepatic perfusion (hypoxic hepatitis from forward cardiac failure). This article provides a comprehensive, up-to-date review on the topic and focuses on the epidemiology, pathology, pathogenesis, clinical manifestations, diagnostic testing and treatment strategies pertaining to liver disease in circulatory failure.

show abstract

“…Furthermore, many patients with cirrhosis have elevated ammonia levels without evidence for encephalopathy. Recent work demonstrated that HE is the interplay between ammonia, inflammatory responses and autoregulation of cerebral hemodynamics [40]. 84 such cirrhotics were studied by Briegel et al [41].…”

Section: Role Of Cytokines In Liver Complicationsmentioning

confidence: 99%

Role of Cytokines in the Pathophysiology of Acute-on-Chronic Liver Failure

Liu¹

2009

Blood Purif

View full text Add to dashboard Cite

Background: This is the first ever decade which has witnessed the emergence of a highly lethal condition termed acute-on-chronic liver failure (ACLF), which today is the leading cause of death compared to acute and chronic liver failure. However, the complex pathophysiology of ACLF remains poorly understood. This article will attempt to summarize recent progress in the understanding of the mechanisms of cytokines in ACLF. Methods: The search terms used on PubMed were cytokines, liver injury, complications of liver disease, and hepatic progenitor cell. Results: Cytokines play a significant role in the pathophysiology of ACLF including hepatocellular death, extrahepatic complications and hepatocyte regeneration. The tissue-damaging mechanisms of cytokines are closely related to their hepatocyte proliferation and regeneration function. Conclusions: It remains a challenge to selectively prevent the detrimental effects of cytokines. To design interventions which selectively target the detrimental effects of cytokines, a detailed understanding of cytokines in the pathophysiology ACLF is critical.

show abstract

Effect of the molecular adsorbent recirculating system and Prometheus devices on systemic haemodynamics and vasoactive agents in patients with acute-on-chronic alcoholic liver failure

Cited by 225 publications

References 51 publications

EASL clinical practice guidelines on the management of ascites, spontaneous bacterial peritonitis, and hepatorenal syndrome in cirrhosis

EASL clinical practice guidelines on the management of ascites, spontaneous bacterial peritonitis, and hepatorenal syndrome in cirrhosis

“Cardiac Hepatopathy”: A Review of Liver Dysfunction in Heart Failure

Role of Cytokines in the Pathophysiology of Acute-on-Chronic Liver Failure

Contact Info

Product

Resources

About