2019
DOI: 10.3390/molecules25010057
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Effect of the Modifications on the Physicochemical and Biological Properties of β-Glucan—A Critical Review

Abstract: β-Glucan exhibits many biological activities and functions such as stimulation of the immune system and anti-inflammatory, anti-microbial, anti-infective, anti-viral, anti-tumor, anti-oxidant, anti-coagulant, cholesterol-lowering, radio protective, and wound healing effects. It has a wide variety of uses in pharmaceutical, cosmetic, and chemical industries as well as in food processing units. However, due to its dense triple helix structure, formed by the interaction of polyhydroxy groups in the β-d-glucan mol… Show more

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Cited by 50 publications
(34 citation statements)
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“…The pharmaceutical application of β-glucans is also limited by its purity, toxicity, viscosity, and weak solubility [ 7 , 107 ]. As an acceptable level of solubility is one of the most important parameters for pharmaceutical agents, improvement of the low solubility of β-glucans is required.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…The pharmaceutical application of β-glucans is also limited by its purity, toxicity, viscosity, and weak solubility [ 7 , 107 ]. As an acceptable level of solubility is one of the most important parameters for pharmaceutical agents, improvement of the low solubility of β-glucans is required.…”
Section: Discussionmentioning
confidence: 99%
“…The β-glucans, a group of polysaccharides consisting of β-(1,3)-linked β- d -glucopyranosyl units as the backbone and β-(1,6)-linked branching chain, exist widely in fungi, plants, some bacteria, seaweeds, and cereals [ 1 , 2 ]. While the anti-tumor, anti-infective, and immunomodulatory activities of β-glucans have been well discussed [ 3 , 4 , 5 , 6 , 7 ], their role in bone metabolism has not been reviewed.…”
Section: Introductionmentioning
confidence: 99%
“…The primary backbone structure of BDG is presented in Figure 3 , with a fungi-typical (1→6)-β-linked glucose branch. The β linkage imposes steric constraints upon the orientation of the adjacent glucose molecules leading to the formation of a helical structure as the polyglucan chain becomes elongated [ 34 , 35 , 36 ]. Side chain addition, or branching, in multiple forms and with multiple moieties is also observed to occur, creating characteristic BDG types among different taxonomic groups [ 37 ].…”
Section: (1→3)-β-glucan Distribution and Structurementioning
confidence: 99%
“…Specifically, routes of administration, dose, time points, populations and length of treatment all vary in preclinical and clinical applications. This approach has led to apparently conflicting findings [ 188 ].…”
Section: Translational Challenges and Opportunitiesmentioning
confidence: 99%