Effect of the membrane surface charge on the host-guest complex of valinomycin in a synthetic lipid monolayer at the air-water interface

Sugawara, Masao; Sazawa, Hiroyuki; Umezawa, Yoshio

doi:10.1021/la00038a051

Cited by 24 publications

(10 citation statements)

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“…This observation led us to think of a “complexing surface effect” rather than of a “blocking effect”. The surface complexation between val and potassium was reported by Umezawa in ref for a negatively charged lipid layer. Despite the zwitterionic nature of DBPC, the negative potential applied to the interface, in our case, would favor the interaction K + −val.…”

Section: Resultssupporting

confidence: 53%

“…Monolayers of mixtures of val and fatty acids were applied to biosensors 6,11 or to study the conformational changes of val generated by the compression of the monolayer. ,, X-ray, crystallography, and high-resolution NMR techniques have been successfully used to assess the array of complexed and uncomplexed val (see ref and references therein). In ref a model has been proposed which describes the host−guest complexation behavior of val in charged lipid membranes at a water/air interface.…”

Section: Introductionmentioning

confidence: 99%

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Valinomycin Adsorption at the Water/1,2-Dichloroethane Interface. Effect on Cation-Transfer Processes

et al. 1998

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The interaction between K+ ions and valinomycin (val) at the water/1,2-dichloroethane interface was studied using voltammetric measurements. The effect of a dibehenoylphosphatidylcholine monolayer adsorbed at the interface was also analyzed. Significant differences between the experimental transfer current and the theoretical values were found, especially for high (C K/C val) concentration ratios, which suggest an interfacial complexation between val and K+ ions. This process is enhanced by the monolayer due to the ability of val to penetrate into phospholipid layers. The transfer of the other alkali cations facilitated by val in the presence and in the absence of the monolayer as well as the behavior of another ligand (dibenzo-18-crown-6, db-18c-6) were analyzed for comparison. In all these cases the experimental results were the expected ones according to a facilitated transfer mechanism. The outstanding results observed for K+ transfer assisted by val are explained, taking into account the high stability constant of the K+−val complex and the surface properties of val.

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Section: Resultssupporting

confidence: 53%

Section: Introductionmentioning

confidence: 99%

Valinomycin Adsorption at the Water/1,2-Dichloroethane Interface. Effect on Cation-Transfer Processes

et al. 1998

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“…Many studies based on this principle have been reported by Umezawa et al Valinomycin imbedded in membranes can act as a receptor molecule for K + . 1,2 The other receptor molecules that can form sensing membranes contain, cyclodextrin, 3,4 DNA, 5 poly(L-glutamic acid), 6,7 lipophilic derivatives of macrocyclic polyamine, 3 thiolcontaining dialkyl phosphate, 8 a hydrogen bond-forming bis(thiourea) compound, 9 glutathione, 10 peptide nucleic acid (PNA), 11 lipid, 1,12-14 etc. The receptor membranes include a Langmuir-Blodgett membrane, 1-4 a self-assembled membrane 5,8,10,11 and a cast membrane.…”

Section: Introductionmentioning

confidence: 99%

Ion-Channel Sensing of Ferricyanide Anion Based on a Supported Bilayer Lipid Membrane

Han

Wang

2001

ANAL. SCI.

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Ferricyanide anion has usually been used as a marker of ion-channel sensors. In this work we first found that ferricyanide, itself, can act as a stimulus to regulate the permeability of sBLM prepared from didodecyldimethylammonium bromide (a kind of synthetic lipid) on a GC electrode. We used cyclic voltammetry and a.c. impedance to investigate this phenomenon. The interaction between sBLM and ferricyanide concerns time. Furthermore, we developed a sensor for ferricyanide anion. The ion-channel sensor is highly sensitive. It can detect ferricyanide concentration as low as 5 µM.

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“…Therefore, valinomycin immobilized in a suitable artificial matrix can behave similarly to gramicidin A and alamethicin, although its native function is different. Valinomycin was investigated both in pure and mixed monolayers by different authors [7][8][9][10][11][12]. The important conclusion is that valinomycin organized in Langmuir monolayer is not able to complex potassium ions, even if spread on very concentrated (1 M) aqueous KCl solution.…”

Section: Introductionmentioning

confidence: 99%

Fluorinated vs hydrogenated surfactants in mixtures with valinomycin—The Langmuir monolayer study

Broniatowski¹,

Vila-Romeu²,

Dynarowicz-Łątka³

2010

Colloids and Surfaces B: Biointerfaces

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Effect of the membrane surface charge on the host-guest complex of valinomycin in a synthetic lipid monolayer at the air-water interface

Cited by 24 publications

References 0 publications

Valinomycin Adsorption at the Water/1,2-Dichloroethane Interface. Effect on Cation-Transfer Processes

Valinomycin Adsorption at the Water/1,2-Dichloroethane Interface. Effect on Cation-Transfer Processes

Ion-Channel Sensing of Ferricyanide Anion Based on a Supported Bilayer Lipid Membrane

Fluorinated vs hydrogenated surfactants in mixtures with valinomycin—The Langmuir monolayer study

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