Effect of the mechanical properties of carbon-based coatings on the mechanics of cell–material interactions

Trembecka-Wójciga, Klaudia; Kopernik, Magdalena; Surmiak, Marcin; Major, R.; Gawlikowski, M.; Brückert, Franz; Kot, M.; Lackner, J.M.

doi:10.1016/j.colsurfb.2020.111359

Cited by 3 publications

(2 citation statements)

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“…The 3D models of blood–material adhesion tests were developed using finite volume method (FVM) in the Ansys Fluent code (Ansys, Inc., Canonsburg, PA, USA): radial flow test model and cone and plane test (Impact-R) model. The first test as a fundamental research test measures cell detachment which occurs for the critical value of the stress [ 51 , 52 ], and the second as a technology test is designed to examine the influence of shear stresses on cardiovascular tissue [ 53 , 54 ]. The values of shear stress and blood flow velocity were computed, implementing boundary conditions imitating real materials surface roughness.…”

Section: Methodsmentioning

confidence: 99%

Hemocompatibile Thin Films Assessed under Blood Flow Shear Forces

et al. 2022

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The aim of this study was to minimize the risk of life-threatening thromboembolism in the ventricle through the use of a new biomimetic heart valve based on metal–polymer composites. Finite volume element simulations of blood adhesion to the material were carried out, encompassing radial flow and the cone and plane test together with determination of the effect of boundary conditions. Both tilt-disc and bicuspid valves do not have optimized blood flow due to their design based on rigid valve materials (leaflet made of pyrolytic carbon). The main objective was the development of materials with specific properties dedicated to contact with blood. Materials were evaluated by dynamic tests using blood, concentrates, and whole human blood. Hemostability tests under hydrodynamic conditions were related to the mechanical properties of thin-film materials obtained from tribological tests. The quality of the coatings was high enough to avoid damage to the coating even as they were exposed up to maximum loading. Analysis towards blood concentrates of the hydrogenated carbon sample and the nitrogen-doped hydrogenated carbon sample revealed that the interaction of the coating with erythrocytes was the strongest. Hemocompatibility evaluation under hydrodynamic conditions confirmed very good properties of the developed coatings.

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Section: Methodsmentioning

confidence: 99%

Hemocompatibile Thin Films Assessed under Blood Flow Shear Forces

et al. 2022

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“…The mechanical properties were estimated by measuring the micro-hardness by applying the scratch test and the wear test at the contact point of the shield. The method was similar to one described elsewhere [ 55 , 56 ]. Indentation tests were carried out at loads of 2 mN and 5 mN and accompanying growth and deceleration speeds of 4 mN/min and 10 mN/min.…”

Section: Methodsmentioning

confidence: 99%

Antibacterial Optimization of Highly Deformed Titanium Alloys for Spinal Implants

et al. 2021

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The goal of the work was to develop materials dedicated to spine surgery that minimized the potential for infection originating from the transfer of bacteria during long surgeries. The bacteria form biofilms, causing implant loosening, pain and finally, a risk of paralysis for patients. Our strategy focused both on improvement of antibacterial properties against bacteria adhesion and on wear and corrosion resistance of tools for spine surgery. Further, a ~35% decrease in implant and tool dimensions was expected by introducing ultrahigh-strength titanium alloys for less-invasive surgeries. The tested materials, in the form of thin, multi-layered coatings, showed nanocrystalline microstructures. Performed direct-cytotoxicity studies (including lactate dehydrogenase activity measurement) showed that there was a low probability of adverse effects on surrounding SAOS-2 (Homo sapiens bone osteosarcoma) cells. The microbiological studies (e.g., ISO 22196 contact tests) showed that implanting Ag nanoparticles into Ti/TixN coatings inhibited the growth of E. coli and S. aureus cells and reduced their adhesion to the material surface. These findings suggest that Ag-nanoparticles present in implant coatings may potentially minimize infection risk and lower inherent stress.

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