Effect of the ionic antineoplastic agent Cytoreg on blood chemistry in the Wistar rat model

Abstract

Cytoreg is an ionic therapeutic agent comprising a mixture of hydrochloric, sulfuric, phosphoric, hydrofluoric, oxalic, and citric acids. In diluted form, it has demonstrated efficacy against human cancers in vitro and in vivo. Although Cytoreg is well tolerated in mice, rats, rabbits, and dogs by oral and intravenous administration, its mechanism of action is not understood. The acidic nature of Cytoreg could potentially disrupt the pH and levels of ions and dissolved gases in the blood. Here, we report the effects of the intravenous administration of Cytoreg on the arterial pH, oxygen and carbon dioxide pressures, and bicarbonate, sodium, potassium, and chloride concentrations. Our results demonstrate that Cytoreg increases oxygen levels and can be used from a therapeutic point of view.

Evaluation of dermal corrosion and irritation by Cytoreg in rabbits

“…In vitro and in vivo studies have shown Cytoreg to have oncolytic activity [ [2] , [3] , [4] , [5] ]. In Wistar rats, oral administration of Cytoreg is well tolerated [ 6 ] and was recently shown to increase arterial blood oxygen pressure (pO 2 ) by iv administration [ 7 ]. We became interested in the potential use of Cytoreg topical solution for the treatment of diabetic foot ulcers, owing to the possible improvement of oxygenation to the damaged tissue.…”