We observe anisotropic Hanle lineshape with unequal in-plane and out-of-plane non-local signals for spin precession measurements carried out on lateral metallic spin valves with transparent interfaces. The conventional interpretation for this anisotropy corresponds to unequal spin relaxation times for in-plane and out-of-plane spin orientations as for the case of 2D materials like graphene, but it is unexpected in a polycrystalline metallic channel. Systematic measurements as a function of temperature and channel length, combined with both analytical and numerical thermoelectric transport models, demonstrate that the anisotropy in the Hanle lineshape is magneto-thermal in origin, caused by the anisotropic modulation of the Peltier and Seebeck coefficients of the ferromagnetic electrodes. Our results call for the consideration of such magnetothermoelectric effects in the study of anisotropic spin relaxation.Electrical spin injection and detection in non-local lateral spin valves have been used extensively to study pure spin currents in non-magnetic (NM) materials [1][2][3][4][5][6][7][8].Hanle measurements allow the manipulation of the spin accumulation in the NM via a perpendicular magnetic field, which induces spin precession as the carriers diffuse along the NM channel. From these experiments, we can extract the spin transport parameters of the channel, like the spin relaxation length and time, and hence get an insight about the nature of spin-orbit interaction (SOI) causing spin relaxation. This is particularly relevant for 2D materials like graphene, where the SOI acting along the in-plane and out-of-the plane directions can differ and lead to anisotropic spin relaxation, manifested by different signals for the in-plane and out-of-plane spin configurations in the Hanle experiments [9,10]. In contrast, for polycrystalline films, spin relaxation is expected to be isotropic [11].In this work we use metallic non-local spin valves (NLSVs), with aluminium (Al) as the NM material, to study spin precession as a function of temperature. Permalloy (Ni 80 Fe 20 , Py) has been used as the ferromagnetic (FM) electrodes to inject a spin-polarized current into Al across a transparent interface and to nonlocally detect the non-equilibrium spin accumulation in Al at a distance L from the injector. This model system with transparent FM/NM interfaces has been thoroughly studied via spin valve measurements. But curiously, corresponding spin precession studies in such systems are scarce. Only recently a few groups have demonstrated spin precession in NLSVs with transparent FM/NM interfaces [12,13], with the NM channel being either silver or copper. More importantly, these few experiments have been done only at low temperatures (T ≤ 10 K), with no reports on Hanle measurements at room temperature for transparent FM/NM interfaces.We demonstrate, through non-local spin precession experiments on Py/Al NLSVs with transparent interfaces, an anomalous Hanle lineshape for T > 150 K, in which the in-plane and out-of-plane spin signals ar...