Effect of the indenopyridine RTI-4587-073 (l) on feline testicle

Abstract

The aim of this study was to describe the seminal, histomorphological and hormonal effects of the oral indenopyridine RTI-4587-073(l) on the cat testicle. Side effects were also recorded. Sixty testicles of adult cats that had been treated (d 0) with RTI-4587-073(l) 12.5 mg/kg PO and randomly hemi-

Key aspects of domestic cat spermatogenesis

“…We have described two typical feline testicular histological patterns, the one caused by androgen deprivation (Garcia Romero et al., 2012) and the massive germ cell desquamation caused by disruption of Sertoli cell junctions (D'Francisco et al., 2019). Thus, mild androgen deprivation during spermatogenesis is often manifested by the retention of mature spermatids without spermiation (Vidal & Whitney, 2014).…”

“…When the Sertoli cell toxicant, RTI‐4587‐073(l), was administered orally (12.5 mg/kg) to tom cats the seminiferous epithelium rapidly vacuolized and sloughed into the tubular lumen causing severe tubular disorganization (D'Francisco et al., 2019). Furthermore, multinucleated giant cells were found both in the germinal epithelium and semen.…”

“…Furthermore, multinucleated giant cells were found both in the germinal epithelium and semen. These cells arose from fusion of exfoliated spermatids with abnormal intercellular bridges (D'Francisco et al., 2019; Vidal & Whitney, 2014). Both pathologic patterns showed to be reversible in one or two spermatogenic cycles after ceasing the administration of the corresponding drugs (D'Francisco et al., 2019; Garcia Romero et al., 2012).…”

Highly efficient microwave‐assisted solvent free sequential one‐pot multicomponent synthesis of novel 2‐hydroxy indenopyridin‐5‐ones and mechanismic computational study

“…Other compounds containing indenopyridine skeleton have also found application as anticancer, antidepressant, coronary dilating, calcium modulating, and anti‐inflammatory agents [10,11]. Because of their beneficial and intriguing biological activities, many researchers in chemistry and medicinal chemistry focus on design and synthesis of novel indenopyridine analogs [12–15]. These purposive efforts evinced the compounds that consist of pyridine‐fused indone (Figure 1B) and benzofuran (Figure 1C) scaffold instead of pyridine‐fused indene (Figure 1D).…”

Divergent Synthesis of Functionalized Indenopyridin-2-ones and 2-Pyridones via Benzyl Group Transfer: Two Cases of Aza-semipinacol-Type Rearrangement

“…Extension of the initial studies, focused on the novel type of rearrangement, revealed that C5-phenyl-substituted 3,6-dihydro-2-pyridone 2b , under the same reaction conditions, gave a greater amount of the rearranged product 5b, together with a small amount of indeno[1,2- b ]pyridin-2-one 6b , both possessing a novel quaternary chiral center ( Scheme 2 , part II). The interesting biological activity of the species built on an indeno[1,2- b ]pyridine skeleton 18 (the same as in 6b ) and a new way of its formation (through the aza-semipinacol rearrangement followed by an electrophilic substitution) prompted us to work out the best possible method for their synthesis. We also wanted to check some possibilities of further functionalization, in particular the applicability of N -iodosuccinimide (NIS) in these transformations.…”