Effect of the Heat-Treated Ti6Al4V Alloy on the Fibroblastic Cell Response

Chávez-Díaz, Mercedes Paulina; Escudero-Rincón, María Lorenza; Arce-Estrada, E.M.; Cabrera-Sierra, R.

doi:10.3390/ma11010021

Cited by 7 publications

(3 citation statements)

References 85 publications

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“…It has been demonstrated that different surface microstructures, e.g. globular, martensitic, bimodal and lamellar types, have been attained on the surface of Ti6Al4V alloy after using various surface treatments [31]. When applying the combination of the alkali -heat pretreatment techniques, a uniform porous sodium hydrogen titanate is formed on the origin substrate surface with the diffusion TiO 2 layer of thickness ranging from several hundreds of nm to several m depending on the heat treatment temperature [32,33].…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Needle-less electrospinning employed for calcium and magnesium phosphate coatings on titanium substrates

Strečková

Sopčák

Štulajterová

et al. 2018

Surface and Coatings Technology

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The needle-less electrospinning method was employed for a preparation of calcium phosphate (CP) and magnesium calcium phosphate (MgCP) fibers as biocompatible coatings on Ti substrate. The polyvinylalcohol, triethyl phosphite, calcium and magnesium nitrates were used for a preparation of spun solutions and subsequent precursor fiber formation. The citric acid of 10 wt% was added to the spun solution in order to increase conductivity as well as a convenient complexing agent. A possible mechanism of complexation process of triethyl phosphite with calcium and magnesium nitrates with citric acid is presented. The optimization of calcination temperatures was defined according to the results obtained from TG/DSC analysis. The XRD analysis confirmed the formation of hydroxyapatite and Mg-whitlockite phases at both used temperatures 600 and 800 °C. The final morphology and thickness of prepared CP and MgCP fibrous coatings was designed by a suitable choice of the used sols, spinning time and calcination temperature. The SEM/FIB observations revealed that the average thickness of the CP coating was around 1 μm, which is almost two times thinner than the MgCP coating with the approximate width 2 μm. The in vitro cytotoxicity tests of the substrate surfaces revealed that the osteoblastic MC3T3-E1 cells have a good proliferation activity when cultured on the 600°C calcined substrates covered by smooth and uniform fibrous nets. A strong cytotoxic cell response was observed in the samples treated at 800°C, where the fibrous coatings were disrupted by the newly formed sharp rutile (TiO 2 ) micro-crystals. Such surface topography acts against the initial adhesion and proliferation of osteoblast like cells.

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Section: Accepted Manuscriptmentioning

confidence: 99%

Needle-less electrospinning employed for calcium and magnesium phosphate coatings on titanium substrates

Strečková

Sopčák

Štulajterová

et al. 2018

Surface and Coatings Technology

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“…Hence, bone tissue is continually changing, being restructured and biologically remodeled throughout life [26]. Biocompatibility is also affected by microstructural changes because the chemical composition of the passive oxide formed on the metal surface is different affecting cell adhesion, biocompatibility, and, consequently, osseointegration [4,[27][28][29]. Some studies on the performance of Ti and titanium alloys against real biological environments have been carried out through in vivo tests with experimental animals [30][31][32][33][34][35].…”

Section: Introductionmentioning

confidence: 99%

Implantation of heat treatment Ti6al4v alloys in femoral bone of Wistar rats

Chávez-Díaz

Henche

Yanchuck

et al. 2022

J Mater Sci: Mater Med

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Two heat treatments were carried out at below (Ti6Al4V800) and above (Ti6Al4V1050) the beta-phase transformation temperature (TTRANSUS = 980 °C), to study the effect of microstructural changes on osseointegration. The alloys were implanted in the femurs of hind legs of Wistar rats for 15, 30, and 60 days. Histology of the femur sections obtained for the first 15 days showed inflammatory tissue surrounding the implants and tissue contraction, which prevented osseointegration in early stages. After 30 days, trabecular bone, reduction of inflammatory tissue around the implants, and osseointegration were observed in Ti6Al4V as received and Ti6Al4V1050 alloys, while osseointegration was detected for the three alloys after 60 days. These results were supported through morphometric studies based on the analysis of Bone Implant Contact (BIC), where there was a larger bone contact after 60 days for the Ti6Al4V1050 alloy; indicating that microstructural features of the Ti6Al4V alloys influence their osseointegration, with the lamellar microstructure (Ti6Al4V1050), being the most responsive.

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“…The microstructure type (bimodal, lamellar and equiaxed) affects the mechanical properties of Ti based alloys [18]. Even though the corrosion of Ti-alloys in different environments has previously beenstudied [19,20,21,22,23], to the best of our knowledge, the literature contains no reports onthe passive layer growth kinetics and breakdown, and subsequent initiation and propagation of pitting corrosion over the surfaces of Ti-6Al-7Nb, Ti-6Al-4V, and TC21 alloys. In this context, the mainobjective of our studywas to assess the effect of microstructure changes of tested alloys on their surface morphology and chemistry using different techniques such as scanning electron microscopy with electron dispersive X-ray spectroscopy (SEM/EDX), X-ray diffraction (XRD), and X-ray Photoelectron Spectroscopy (XPS).…”

Section: Introductionmentioning

confidence: 99%

The Influence of Microstructure on the Passive Layer Chemistry and Corrosion Resistance for Some Titanium-Based Alloys

et al. 2019

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The effect of microstructure and chemistry on the kinetics of passive layer growth and passivity breakdown of some Ti-based alloys, namely Ti-6Al-4V, Ti-6Al-7Nb and TC21 alloys, was studied. The rate of pitting corrosion was evaluated using cyclic polarization measurements. Chronoamperometry was applied to assess the passive layer growth kinetics and breakdown. Microstructure influence on the uniform corrosion rate of these alloys was also investigated employing dynamic electrochemical impedance spectroscopy (DEIS). Corrosion studies were performed in 0.9% NaCl solution at 37 °C, and the obtained results were compared with ultrapure Ti (99.99%). The different phases of the microstructure were characterized by X-ray diffraction (XRD) and scanning electron microscopy (SEM). Chemical composition and chemistry of the corroded surfaces were studied using X-ray photoelectron spectroscopy (XPS) analysis. For all studied alloys, the microstructure consisted of α matrix, which was strengthened by β phase. The highest and the lowest values of the β phase’s volume fraction were recorded for TC21 and Ti-Al-Nb alloys, respectively. The susceptibility of the investigated alloys toward pitting corrosion was enhanced following the sequence: Ti-6Al-7Nb < Ti-6Al-4V << TC21. Ti-6Al-7Nb alloy recorded the lowest pitting corrosion resistance (Rpit) among studied alloys, approaching that of pure Ti. The obvious changes in the microstructure of these alloys, together with XPS findings, were adopted to interpret the pronounced variation in the corrosion behavior of these materials.

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Effect of the Heat-Treated Ti6Al4V Alloy on the Fibroblastic Cell Response

Cited by 7 publications

References 85 publications

Needle-less electrospinning employed for calcium and magnesium phosphate coatings on titanium substrates

Needle-less electrospinning employed for calcium and magnesium phosphate coatings on titanium substrates

Implantation of heat treatment Ti6al4v alloys in femoral bone of Wistar rats

The Influence of Microstructure on the Passive Layer Chemistry and Corrosion Resistance for Some Titanium-Based Alloys

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