Effect of the glyceryl monooleate-based lyotropic phases on skin permeation using in vitro diffusion and skin imaging

Lim, Dae Gon; Jeong, Won-Wook; Kim, Nam Ah; Lim, Jun Yeul; Lee, Seol‐Hoon; Shim, Woo Sun; Kang, Nae Gyu; Jeong, Seong Hoon

doi:10.1016/j.ajps.2014.06.008

Cited by 29 publications

(12 citation statements)

References 15 publications

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“…The effects of the initial water proportion on drug release have been studied and several conflicting results were found among the researches. Some studies reported that LLC with a higher initial water proportion could provide a faster drug release because of the better hydrated matrix and bigger hydrophilic water channels (48,49). Other authors stated that there was no difference in the drug release behavior as a function of the initial water proportion because the water was rapidly taken up when the formation of a viscous cubic phase occurred (50,51).…”

Section: In Vitro Drug Release Studiesmentioning

confidence: 99%

Cubic Liquid Crystalline Gels Based on Glycerol Monooleate for Intra-articular Injection

Cao

et al. 2017

AAPS PharmSciTech

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In situ gels containing sinomenine hydrochloride (SMH) for intra-articular (IA) administration to treat rheumatoid arthritis (RA) were designed and investigated in this study. Glycerol monooleate (GMO) was used due to the potential to generate viscous crystalline phase structures upon water absorption. The gels were evaluated using different parameters: syringeability, gelation, viscosity, and drug release. And, polarized light microscopy (PLM), small-angle X-ray scattering investigation (SAXS), and rheological studies were used to analyze their internal structures. In vitro drug release studies were performed by the dialysis membrane diffusion method. The syringeability, viscosity, gelation time, and water for gelation of the obtained preparation met the requirements of IA injection. PLM, SAXS, and rheological analysis showed that all samples had transformed from flowable isotropic solution phases to the inverse cubic (V) phases upon excess water. And, the gels were found to be able to maintain the drug release for more than 1 week. Results showed that in situ gels based on GMO liquid crystalline could provide a sustained system for SMH. Due to its sustained release, the in situ cubic gels were suitable for IA injection to treat RA.

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Section: In Vitro Drug Release Studiesmentioning

confidence: 99%

Cubic Liquid Crystalline Gels Based on Glycerol Monooleate for Intra-articular Injection

Cao

et al. 2017

AAPS PharmSciTech

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“…The literature reports various approaches such as the use of bile salts, saponins [1] , straight chain fatty acids [2] , microemulsion [3] , nanoemulsion [4] , cyclodextrin inclusion complex [5] , chitosan derivatives [6] , self-micro-emulsifying drug delivery systems [7] , interfacial cohesion and supramolecular assembly of bioadhesive species [8] (including liquid crystals) for permeation enhancement of BCS-III drugs [9] . Additionally, advanced technologies, such as iontophoresis [10] , ultrasound [11] , microneedles [12] , [13] , electroporation [14] , radiofrequency [15] , and microporation [16] have been used for enhancing the transdermal permeation of drugs.…”

Section: Introductionmentioning

confidence: 99%

QbD based approach for optimization of Tenofovir disoproxil fumarate loaded liquid crystal precursor with improved permeability

Patil

Kadam

Pokharkar

2017

Journal of Advanced Research

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“…The so-called skin permeation enhancers (such as, surfactants, natural oils, hydrocarbons and fatty acids) which are being looked at by several researchers (Naik et al 1995;Tanojo et al 1999;Lim et al 2014;Pandey et al 2014) can improve the penetration of bioessential substances by perturbing the barrier function of the stratum corneum.…”

Section: Edible Claymentioning

confidence: 99%

Healing and edible clays: a review of basic concepts, benefits and risks

Gomes

2017

Environ Geochem Health

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The use of clay by humans for medicinal and wellness purposes is most probably as old as mankind. Within minerals, due to its ubiquitous occurrence in nature and easy availability, clay was the first to be used and is still used worldwide. Healing clays have been traditionally used by man for therapeutic, nutritional and skin care purposes, but they could impart some important health and skin care risks. For instance, clay particles could adsorb and make available for elimination or excretion any potential toxic elements or toxins being ingested or produced, but they could adsorb and make available for incorporation, through ingestion or through dermal absorption, toxic elements, e.g. heavy metals. Edible clays, a particular case of healing clays, have been traditionally used by man for nutritional and therapeutic purposes. Geophagy, the deliberate soil eating, earth eating, clay eating and pica (medical condition or eating disorder shown by individuals addicted to eat earth substances), has been observed in all parts of the world since antiquity, reflecting cultural practice, religious belief and physiological needs, be they nutritional (dietary supplementation) or as a remedy for disease. This paper pretends to review historical data, basic concepts and functions, as well as benefits and risks of the use of healing clays, in general, for therapeutic and cosmetic purposes, and of edible clays, in particular, for therapeutic purposes.

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Effect of the glyceryl monooleate-based lyotropic phases on skin permeation using in vitro diffusion and skin imaging

Cited by 29 publications

References 15 publications

Cubic Liquid Crystalline Gels Based on Glycerol Monooleate for Intra-articular Injection

Cubic Liquid Crystalline Gels Based on Glycerol Monooleate for Intra-articular Injection

QbD based approach for optimization of Tenofovir disoproxil fumarate loaded liquid crystal precursor with improved permeability

Healing and edible clays: a review of basic concepts, benefits and risks

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