Effect of the Freezing Conditions and Microwave Thawing Power on the Stability of Cefuroxime in Dextrose 5% Infusion Polyolefin Bags at 4 °C

Abstract

The optimal conditions for advance preparation of a solution containing cefuroxime 1.5% in dextrose 5% may be freezing of individual containers followed by a light cycle of microwave thawing.

Stability of Commonly Used Antibiotic Solutions in an Elastomeric Infusion Device

“…Previously published studies for cefazolin, [15][16][17][18][19][20][21] ceftazidime, 7,18,20,22 ceftriaxone, 6,18,20,[23][24][25][26] clindamycin, 17,21,[26][27][28] and vancomycin 8,[29][30][31] all reported stability data and expiration dates that were in general agreement with the results reported here. In some cases, the recommended expiry dates in those previously studies were longer than those determined in the current study, largely because the beyond-use dates calculated here were based on 95% CIs, whereas 95% CIs were not calculated in most of the earlier studies.…”

“…[6][7][8][15][16][17][18][19][20][21][22][23][24][26][27][28][29][30] Previously published studies often used only linear regression to calculate the percent remaining on the last study day. The time to reach 90% of the initial concentration (T-90%) can be calculated on the basis of the observed concentration remaining as reported in previous publications [6][7][8][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31] and compared to the T-90% determined for each drug in the current study (Table 7, Figure 1). Calculation of T-90% yields a better overall estimate of expiry date because it minimizes the effect of study duration and day-to-day variability in the estimates of concentration.…”

Physico-chemical analysis of several injectable drug in ready-to-use infusion after microwave freeze-thaw treatment and final storage at 5±3̊C

“…The cycles were described in a previous publication [44], comparing light cycle and hard cycle of defrosting on the same drug, cefuroxime, in dextrose 5% infusion polyolefin bags. Ten bags were frozen individually in one drawer and ten bags were frozen with 40 other polyolefin bags in another drawer.…”

Microwave freeze-thaw technique of injectable drugs. A review from 1980 to 2014

“…Ampicilline need temperature of storage from -30 • C to -70 • C, not currently obtained with a majority of freezers [27]. Cefuroxime needs to be stored at a temperature equal or inferior to -20 • C [30,[38][39][40].…”