Effect of the extract of Annona muricata and Petunia nyctaginiflora on Herpes simplex virus

Padma, P. R.; Pramod, N P; Thyagarajan, Sadras Panchatcharam; Khosa, R. L.

doi:10.1016/s0378-8741(98)00013-0

Cited by 64 publications

(33 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In Colombia, it is used to treat malaria (Blair et al, 1991); it has been used in folk medicine because of anti-diarrheic, anti-diabetic and abortive properties (Coee and Anderson, 1996). This plant also has antiviral, insecticide, molluscacide and antiparasitic properties (Bories et al, 1991;Padma et al, 1998;Dos Santos and Sant'Ana, 2001;Labaut et al, 2001;Luna et al, 2005Luna et al, , 2006. Previous studies have described antiparasitic activity of seed extracts of Annona muricata and other Annona species (Bories et al, 1991;Sahpaz et al, 1994).…”

Section: Discussionmentioning

confidence: 99%

Antiprotozoal and cytotoxic activities in vitro of Colombian Annonaceae

Osorio

Arango

Jimenez

et al. 2007

Journal of Ethnopharmacology

141

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Antiprotozoal and cytotoxic activities in vitro of Colombian Annonaceae

Osorio

Arango

Jimenez

et al. 2007

Journal of Ethnopharmacology

141

View full text Add to dashboard Cite

“…5) Methanol extracts of Indonesian plants were tested for cytotoxicity and antiviral activity (HSV-1 and poliovirus) in murine and human cell lines. Piper aduncum was found to be active on poliovirus, while Elytranthe tubaeflora and Melastoma malabathricum inhibited HSV-1.…”

mentioning

confidence: 99%

Antiviral Effect of Guazuma ulmifolia and Stryphnodendron adstringens on Poliovirus and Bovine Herpesvirus

Felipe

Rincão

Benati

et al. 2006

Biological & Pharmaceutical Bulletin

View full text Add to dashboard Cite

Works on antiviral compounds date back to the 1950s, but for several reasons, only a couple of drugs were approved for clinical use about a decade later. To date, many antiviral drugs have been developed after extensive research and demanding trials, some of them with selective mechanisms against viral replication. 1) Although the primary focus has been on synthetic products, the number of natural compounds with antiviral action for different DNA and RNA viruses that are being studied is increasing. Many phytochemical compounds are being investigated based primarily on ethnopharmacologic knowledge and have been considered of great importance in new drug development. 2)Extracts of many plant species, such as Tridax procumbens, Carissa carandas, Mallotus philippensis, Streblus aspere, Terminatta alata, Macaranga pustulata, Sibbaldia micropetala, Hypericum cordifolium, H. uralum and Maesa macrophylla were found to be active against the replication of poliovirus and herpes simplex-1 (HSV-1), with some of them also active against Sindbis virus.3,4) A methanol extract of Annona muricata and aqueous extract of Petunia myctaginiflora were shown to inhibit HSV-1 cytopathic effect in Vero cells, at a concentration of 1 mg/ml. 5)Methanol extracts of Indonesian plants were tested for cytotoxicity and antiviral activity (HSV-1 and poliovirus) in murine and human cell lines. Piper aduncum was found to be active on poliovirus, while Elytranthe tubaeflora and Melastoma malabathricum inhibited HSV-1. 6) Dengue virus was inhibited by an aqueous extract of Azadirachta indica when assayed in mice. 7)Stem bark of Stryphnodendron adstringens (MART.) COV-ILLE, Leguminosae, popularly known in our country as barbatimão, has been empirically used as wound healing, astringent, antimicrobial, antifungal, antidiarrheal and hypoglycemic agents.8) Similarly, Guazuma ulmifolia LAM., Sterculiaceae, popularly known as mutamba, is known to have medicinal properties, such as wound healing, antiulcerogenic, hypoglycemic and antimicrobial. 9) G. ulmifolia aqueous and methanol fractions were found to inhibit HSV-1 replication, respectively, by 16.8% and 4.5%, at a concentration of 100 mg/ml, in a study of various plants. Those showing antiviral activity in vitro were also tested in HSV-1 infected mice. Melaleuca leucadendron and Nephelium lappaceum reduced mortality and delayed the appearance of lesions. 10)Among plant antiviral compounds, anthraquinones found in Aloe barbadensis inhibited HSV-1, HSV-2, varicela-zoster, pseudorabies and influenza.11) Stevia rebaudiana polysaccharides inhibited adsorption of human rotavirus in MA-104 cells.12) Flavonoids present in Troillius chinensis flowers also inhibited parainfluenza in HEp-2 cells.13) Quassia africana extracts were tested for HSV-1, coxsackie B2, polio-1, measles, Semliki Forest virus and vesicular stomatitis virus, where simalikalactone D was found to be responsible for the antiviral effect.14) Anagyrine, oxymatrine, sophoranol, wogonin and oroxylin found in Sophora flavescens and Scutellaria b...

show abstract

“…An early study reported their cardiotonic activity [119]. Soursop (Annona muricata) has been studied for anti-HSV-1 (herpes simplex virus 1) activity showing a total cytopathic effect inhibition at 1 mg/mL [120]. Sugar apples (Annona squamosa) yielded positive hypoglycemic effects on alloxan-induced diabetic rabbits.…”

Section: Annonaceae Familymentioning

confidence: 99%

Major Australian tropical fruits biodiversity: Bioactive compounds and their bioactivities

Pierson

Dietzgen

Shaw

et al. 2011

Molecular Nutrition Food Res

View full text Add to dashboard Cite

The plant kingdom harbours many diverse bioactive molecules of pharmacological relevance. Temperate fruits and vegetables have been highly studied in this regard, but there have been fewer studies of fruits and vegetables from the tropics. As global consumers demand and are prepared to pay for new appealing and exotic foods, tropical fruits are now being more intensively investigated. Polyphenols and major classes of compounds like flavonoids or carotenoids are ubiquitously present in these fruits, as they are in the temperate ones, but particular classes of compounds are unique to tropical fruits and other plant parts. Bioactivity studies of compounds specific to tropical fruit plants may lead to new drug discoveries, while the synergistic action of the wide range of diverse compounds contained in plant extracts underlies nutritional and health properties of tropical fruits and vegetables. The evidence for in vitro and animal bioactivities is a strong indicator of the pharmacological promise shown in tropical fruit plant biodiversity. In this review, we will discuss both the occurrence of potential bioactive compounds isolated and identified from a selection of tropical fruit plants of importance in Australia, as well as recent studies of bioactivity associated with such fruits and other fruit plant parts.

show abstract

Effect of the extract of Annona muricata and Petunia nyctaginiflora on Herpes simplex virus

Cited by 64 publications

References 5 publications

Antiprotozoal and cytotoxic activities in vitro of Colombian Annonaceae

Antiprotozoal and cytotoxic activities in vitro of Colombian Annonaceae

Antiviral Effect of Guazuma ulmifolia and Stryphnodendron adstringens on Poliovirus and Bovine Herpesvirus

Major Australian tropical fruits biodiversity: Bioactive compounds and their bioactivities

Contact Info

Product

Resources

About