Effect of the enterotropic carcinogen 1,2-dimethylhydrazine on the hypothalamic biogenic amine level in rats

Anisimov, Vladimir N.; Pozdeev, V. K.; Dmitrievskaya, A. Yu.; Gracheva, G. M.; Il'in, A. P.; Dilman, V.M.

doi:10.1007/bf00790390

Cited by 2 publications

(1 citation statement)

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“…Shortly after starting DMH treatment, exposed organisms experienced significant disturbances in their neuroendocrine and immune systems and lipid and carbohydrate metabolisms. DMH treatment was followed by an increase in sensitivity threshold of the hypothalamus to inhibition by estrogen 21 , decrease in hypothalamic biogenic amine content 22 , and disturbances in diurnal rhythms at biogenic amine levels in hypothalamic nuclei of rats 23 . Anti-diabetic biguanide treatment alleviated immunodepression in rodents exposed to DMH 24 and AOM 25 .…”

Section: Discussionmentioning

confidence: 99%

Metformin prevents hormonal and metabolic disturbances and 1,2-dimethylhydrazine-induced colon carcinogenesis in non-diabetic rats

Bekusova

Patsanovskii

Nozdrachev

et al. 2017

Cancer Biology &Amp; Medicine

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Effects of two doses of the anti-diabetic drug, metformin (MF), on hormonal and metabolic levels of serum of non-diabetic male Wistar rats with 1,2-dimethylhydrazine (DMH)-induced colon tumor adenocarcinomas were studied. Carcinogenesis in the animals was also observed. Rats with DMH-induced colon adenocarcinomas had elevated levels of serum glucose, insulin, insulin-like growth factor-1, total cholesterol, triglycerides, catalase, malonic dialdehyde, glycated hemoglobin, aspartate aminotransferase, and alanine aminotransferase and decreased hemoglobin. Treatment with two doses of MF normalized majority of these changes in DMH-treated rats, whereas the drug was ineffective in rats without DMH treatment. The only exception was the decreased triglyceride levels in MF-treated rats. A 100 mg/kg dose of MF increased DMH-induced exophytic colon carcinomas and decreased endophytic tumors compared with untreated rats. Moreover, both MF doses increased DMH-induced and highly differentiated tumors and decreased the invasiveness of colon carcinomas compared with rats provided with DMH and water. Therefore, effects of MF on metabolic homeostasis are critical for preventing colon cancer.

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Section: Discussionmentioning

confidence: 99%