Effect of the drug combination of magnesium sulfate and phentolamine on homocysteine and c‑reactive protein in the serum of patients with pregnancy‑induced hypertension syndrome

Abstract

Effect and clinical efficacy of magnesium sulfate combined with phentolamine on homocysteine and C-reactive protein in the serum of patients with pregnancy-induced hypertension syndrome were investigated. A total of 96 patients with pregnancy-induced hypertension syndrome who were diagnosed and treated in Jining No. 1 People's Hospital from February 2016 to January 2018 were retrospectively analyzed. The patients were grouped according to the dosage regimen. The patients who received the combination treatment of magnesium sulfate and phentolamine on the basis of magnesium sulfate were included in the observation group, and the patients who were treated with the intravenous infusion of magnesium sulfate alone were included in the control group. Mean arterial pressure (MAP), the content of 24 h urine protein, systolic blood pressure (SBP), diastolic blood pressure (DBP), Hcy, and CRP of the pregnant women were observed. MAP and the content of 24 h urine protein, SBP and DBP of the patients in the observation group after the treatment were significantly lower than those of the patients in the control group (P<0.001). Hcy and CRP of the patients in the observation group after the treatment were significantly lower than those of the patients in the control group (P<0.001). The total effective rate of the patients in the observation group was significantly higher than that of the patients in the control group (P<0.05). In conclusion, the meliorative effect of magnesium sulphate combined with phentolamine on the level of MAP, the content of 24 h urine protein, SBP, DBP, Hcy and CRP in pregnant woman had a greater impact than that of the single use of the intravenous infusion of magnesium sulfate in the treatment of pregnancy-induced hypertension syndrome, and the clinical efficacy of magnesium sulphate combined with phentolamine was better, thus worthwhile to promote widely in clinic.

Low Magnesium in Conjunction with High Homocysteine and Less Sleep Accelerates Telomere Attrition in Healthy Elderly Australian

“…We also found that Hcy is strongly associated with magnesium. Recently it has been shown in pregnant women that treatment with magnesium sulfate and phentolamine resulted in the significant lowering of Hcy levels [ 43 ]. We can therefore anticipate that magnesium might play an important role in correcting Hcy levels.…”

“…There are few reports in the literature that investigated the role of magnesium and Hcy together on TL. Higher Hcy is associated with shorter telomeres [ 17 , 43 , 44 ]. We then asked if magnesium level is associated with higher Hcy levels.…”

Effect of baicalin on gestational hypertension-induced vascular endothelial cell damage

“…The positive group was injected with magnesium sulfate (100 mg/kg), which is an effective drug to induce hypertension in pregnancy. 21 , 22 The baicalin groups were injected with different doses of the baicalin. The blood pressure (systolic blood pressure) in the caudal artery of these pregnant rats was detected on days 8 and 18, respectively.…”

Uterine Ultrasound Doppler Hemodynamics of Magnesium Sulfate Combined with Labetalol in the Treatment of Pregnancy-Induced Hypertension Using Empirical Wavelet Transform Algorithm

“…Pregnancy-induced hypertension (PIH) is one of the most serious complications during pregnancy, which is characterized by high morbidity and high mortality [ 1 ]. The incidence of PIH is 9.4% in China and 7% to 12% in foreign countries [ 2 ].…”