Effect of the crossing-structure sequence on mixing performance within three-dimensional micromixers

Feng, Xiangsong; Ren, Yukun; Jiang, Hongyuan

doi:10.1063/1.4881275

Cited by 26 publications

(16 citation statements)

References 28 publications

(24 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Numerous investigations have been conducted to achieve efficient and effective mixing in short time and length. Passive and active mixers play an important role in this regard. Passive mixers employ large numbers of obstacles along the flow path to enhance interfacial area between two streams to be stirred .…”

Section: Introductionmentioning

confidence: 99%

Rapid mixing with high‐throughput in a semi‐active semi‐passive micromixer

Kunti

Bhattacharya

2017

Electrophoresis

View full text Add to dashboard Cite

In this paper, we investigate a novel alternating current electrothermal (ACET) micromixer driven by a high efficiency ACET micropump. The micromixer consists of thin film asymmetric pairs of electrodes on the microgrooved channel floor and array of electrode pairs fabricated on the top wall. By connecting electrodes with AC voltage, ACET forces are induced. Asymmetric microgrooved electrodes force the fluids along the channel, while lateral vortex pairs are generated by symmetric electrode pairs located on the top wall. Waviness of the floor increases contact area between two confluent streams within a narrow confinement. An active mixer operates as a semi active semi passive mixer. Effects of various parameters are investigated in details in order to arrive at an optimal configuration that provides for efficient mixing as well as appreciable transport. It is found that using a specific design, uniform and homogeneous mixing quality with mixing efficiency of 97.25% and flow rate of 1.794μm2/ min per unit width of the channel can be achieved.

show abstract

Section: Introductionmentioning

confidence: 99%

Rapid mixing with high‐throughput in a semi‐active semi‐passive micromixer

Kunti

Bhattacharya

2017

Electrophoresis

View full text Add to dashboard Cite

show abstract

“…However, it takes a few weeks and on average hundreds of dollars to manufacture one chip ( production steps including etching and dicing the silicon wafer and bonding it with glass). To this end, we are experimenting to apply a threedimensional micromixer to decrease the pressure drop within the chip [49], so that we can switch to plastic (e.g. polydimethylsiloxane) for faster and cheaper manufacture of the chips.…”

Section: Time-resolved Cryo-emmentioning

confidence: 99%

Two promising future developments of cryo-EM: capturing short-lived states and mapping a continuum of states of a macromolecule

Chen

Frank²

2015

Microscopy (Tokyo)

View full text Add to dashboard Cite

The capabilities and application range of cryogenic electron microscopy (cryo-EM) method have expanded vastly in the last two years, thanks to the advances provided by direct detection devices and computational classification tools. We take this review as an opportunity to sketch out promising developments of cryo-EM in two important directions: (i) imaging of short-lived states (10-1000 ms) of biological molecules by using timeresolved cryo-EM, particularly the mixing-spraying method and (ii) recovering an entire continuum of coexisting states from the same sample by employing a computational technique called manifold embedding. It is tempting to think of combining these two methods, to elucidate the way the states of a molecular machine such as the ribosome branch and unfold. This idea awaits further developments of both methods, particularly by increasing the data yield of the time-resolved cryo-EM method and by developing the manifold embedding technique into a user-friendly workbench.

show abstract

“…14,15 Of the various micromixers reported in the past years, passive mixers, which have included lamination, 16,17 intersecting or disturbing channels, 18,19 and droplet-based platforms, 20,21 have not required energy input or moving parts. Passive mixers are, however, difficult to integrate into organs-on-a-chip systems due to the complexity of their structures.…”

Section: Introductionmentioning

confidence: 99%

In-plane microvortices micromixer-based AC electrothermal for testing drug induced death of tumor cells

et al. 2016

Self Cite

View full text Add to dashboard Cite

Herein, we first describe a perfusion chip integrated with an AC electrothermal (ACET) micromixer to supply a uniform drug concentration to tumor cells. The inplane fluid microvortices for mixing were generated by six pairs of reconstructed novel ACET asymmetric electrodes. To enhance the mixing efficiency, the novel ACET electrodes with rotating angles of 0 , 30 , and 60 were investigated. The asymmetric electrodes with a rotating angle of 60 exhibited the highest mixing efficiency by both simulated and experimental results. The length of the mixing area is 7 mm, and the mixing efficiency is 89.12% (approximate complete mixing) at a voltage of 3 V and a frequency of 500 kHz. The applicability of our micromixer with electrodes rotating at 60 was demonstrated by the drug (tamoxifen) test of human breast cancer cells (MCF-7) for five days, which implies that our ACET inplane microvortices micromixer has great potential for the application of drug induced rapid death of tumor cells and mixing of biomaterials in organs-on-a-chip systems. Published by AIP Publishing. [http://dx

show abstract

Effect of the crossing-structure sequence on mixing performance within three-dimensional micromixers

Cited by 26 publications

References 28 publications

Rapid mixing with high‐throughput in a semi‐active semi‐passive micromixer

Rapid mixing with high‐throughput in a semi‐active semi‐passive micromixer

Two promising future developments of cryo-EM: capturing short-lived states and mapping a continuum of states of a macromolecule

In-plane microvortices micromixer-based AC electrothermal for testing drug induced death of tumor cells

Contact Info

Product

Resources

About