Effect of the consumption of a fruit and vegetable soup with high in vitro carotenoid bioaccessibility on serum carotenoid concentrations and markers of oxidative stress in young men

Martínez-Tomás, Rebeca; Larqué, Elvira; González-Silvera, Daniel; Sánchez-Campillo, María; Burgos, M. I.; Wellner, Anna; Parra, Soledad; Bialek, Lucy; Alminger, Marie; Pérez‐Llamas, Francisca

doi:10.1007/s00394-011-0211-6

Cited by 18 publications

(15 citation statements)

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“…Serum carotenoids, a family of lipophilic plant pigments with potent antioxidant activity, are considered a reliable biomarker of fruit and vegetable intake [31]. Serum responses to carotenoids have been reported to depend on a variety of factors, including the amount consumed, food matrix, and half-life variability of individual carotenoids [32]. The predominant carotenoids in human sera are α-carotene, β-carotene, β-cryptoxanthin, lycopene, lutein, and zeaxanthin [33].…”

Section: Introductionmentioning

confidence: 99%

Fruit and vegetable intake, as reflected by serum carotenoid concentrations, predicts reduced probability of polychlorinated biphenyl–associated risk for type 2 diabetes: National Health and Nutrition Examination Survey 2003-2004

et al. 2014

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Type 2 diabetes has been shown to occur in response to environmental and genetic influences, among them nutrition, food intake patterns, sedentary lifestyle, body mass index (BMI), and exposure to persistent organic pollutants (POPs), such as polychlorinated biphenyls (PCBs). Nutrition is essential in the prevention and management of type 2 diabetes and has been shown to modulate the toxicity of PCBs. Serum carotenoid concentrations, considered a reliable biomarker of fruit and vegetable intake, are associated with the reduced probability of chronic diseases, such as type 2 diabetes and cardiovascular disease. Our hypothesis is that fruit and vegetable intake, reflected by serum carotenoid concentrations, is associated with the reduced probability of developing type 2 diabetes in US adults with elevated serum concentrations of PCBs 118, 126, and 153. This cross-sectional study utilized the CDC database, National Health and Nutrition Examination Survey (NHANES) 2003–2004 in logistic regression analyses. Overall prevalence of type 2 diabetes was approximately 11.6% depending on the specific PCB. All three PCBs were positively associated with the probability of type 2 diabetes. For participants at higher PCB percentiles (e.g., 75th and 90th) for PCB 118 and 126, increasing serum carotenoid concentrations were associated with a smaller probability of type 2 diabetes. Fruit and vegetable intake, as reflected by serum carotenoid concentrations, predicted notably reduced probability of dioxin-like PCB-associated risk for type 2 diabetes.

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Section: Introductionmentioning

confidence: 99%

Fruit and vegetable intake, as reflected by serum carotenoid concentrations, predicts reduced probability of polychlorinated biphenyl–associated risk for type 2 diabetes: National Health and Nutrition Examination Survey 2003-2004

et al. 2014

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“…The soups, used for the in vitro studies and two separate human studies [25,26] were produced by Unilever, the Netherlands within the "Healthy Structuring" project, supported by the European Commission. The project aimed to formulate validated processing solutions to improve the nutritional, structural and sensorial quality of readyto-eat fruit and vegetable products.…”

Section: Methodsmentioning

confidence: 99%

“…In the pilot human study [25], 14 male subjects consumed an optimized soup (300 ml/day) for 4 weeks. One serving of the soup contained 3.9 mg β-carotene, 4 mg lycopene and 5% olive oil.…”

Section: Studymentioning

confidence: 99%

Applicability of in Vitro Models in Predicting the in Vivo Bioavailability of Lycopene and β-Carotene from Differently Processed Soups

Alminger¹,

Svelander²,

Wellner³

et al. 2012

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Presently, there is no clear consensus on the best approach to estimate carotenoid bioavailability. The best alternative would be to use human studies, but they are labour-intensive and expensive and can only be used to investigate a limited number of samples. Hence, a number of in vitro models have been developed to study pre-absorptive processes and factors affecting bioavailability. The question is, however, how well the results obtained by the various methods correlate to each other and to the in vivo situation. In the present paper, we have compared in vivo data from two human studies on differently processed soups containing carrots, tomato and broccoli, with results obtained by in vitro characterisation of the same soups. In vitro bioaccessibility was estimated by a static in vitro digestion investigating matrix release and micellarization of carotenoids and by uptake studies in a human intestinal cell line (Caco-2). In vivo data was obtained from clinical studies measuring total plasma carotenoid concentrations in human subjects after 4 weeks daily consumption of the soups. Comparison of the in vitro and in vivo results indicate that the combination of a two-step in vitro digestion and Caco-2 cells seems to be a useful tool for estimation of β-carotene bioaccessibility and screening of factors governing the release of β-carotene from this type of food. For lycopene the in vitro and in vivo results were less consistent, suggesting that reliable prediction of lycopene bioavailability might be more problematic.

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“…Epidemiological evidence has shown an inverse correlation between regular consumption of fruits and vegetables and the prevalence of chronic diseases, with the protective effect being attributed to antioxidant nutrients in these foods (6,7). In this sense, the intake of these compounds appears to be a strategy for preventing lipid peroxidation and atherosclerosis (8).…”

Section: Introductionmentioning

confidence: 99%

Consumption of Nutrients with Antioxidant Action and its Relationship with Lipid Profile and Oxidative Stress in Student Users of University Restaurant

et al. 2017

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Consumption of nutrients with antioxidant action and its relationship with lipid profi le and oxidative stress in student users of a university restaurant ResumenIntroducción: la relación entre la dieta y la salud ha despertado interés científi co, especialmente en lo referente al consumo de nutrientes antioxidantes presentes de forma natural en los alimentos, debido a su acción contra los efectos nocivos de los radicales libres en el cuerpo. Objetivo: el objetivo de este estudio fue estimar la ingesta de nutrientes antioxidantes y su relación con el perfi l lipídico y el estrés oxidativo en estudiantes usuarios de un restaurante universitario, en comparación con los no usuarios. Métodos: este es un estudio transversal que incluye 145 estudiantes universitarios, divididos en dos grupos: los usuarios del restaurante universitario (grupo 1, n = 73) y no usuarios (grupo 2, n = 72). Fueron medidos el índice de masa corporal y la circunferencia de la cintura, y se estimó la ingesta de micronutrientes antioxidantes. Se determinaron las concentraciones séricas de colesterol total, colesterol unido a lipoproteínas de alta densidad, colesterol unido a lipoproteínas de baja densidad, los niveles de triglicéridos y las concentraciones plasmáticas de malondialdehído. Resultados y conclusiones: la ingesta de cobre, zinc, selenio y la vitamina C se encontraba dentro de las recomendaciones de los dos grupos, y la de vitaminas A y E estaba por debajo de los valores de referencia. Hubo una correlación entre el consumo de vitamina C y los triglicéridos. Miembros del grupo 1 mostraron mejores patrones dietéticos en relación con micronutrientes antioxidantes, lo que refl eja menos perfi l lipídico aterogénico y una menor exposición al estrés oxidativo en comparación con el grupo 2. AbstractIntroduction: The relationship between diet and health has aroused scientifi c interest, especially the consumption of antioxidant nutrients naturally present in foods, because of its action against the deleterious effects of free radicals in the body. Objective: This study aimed to estimate the intake of antioxidant nutrients and its relationship with lipid profi le and oxidative stress in student users of a university restaurant in comparison with non-users. Methods: This cross-sectional study involved 145 university students divided into two groups: users of the university restaurant (group 1, n = 73) and non-users (group 2, n = 72). We measured body mass index and waist circumference, and estimated the intake of antioxidant micronutrients. Serum concentrations of total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and triglyceride levels, and plasma concentrations of malondialdehyde were determined. Results and conclusion: Intake of copper, zinc, selenium, and vitamin C were within the recommendations in both groups, and vitamins A and E were below the reference values. There was a correlation between the intake of vitamin C and triglycerides. Group 1 members had better dietary patterns in relation t...

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Effect of the consumption of a fruit and vegetable soup with high in vitro carotenoid bioaccessibility on serum carotenoid concentrations and markers of oxidative stress in young men

Cited by 18 publications

References 50 publications

Fruit and vegetable intake, as reflected by serum carotenoid concentrations, predicts reduced probability of polychlorinated biphenyl–associated risk for type 2 diabetes: National Health and Nutrition Examination Survey 2003-2004

Fruit and vegetable intake, as reflected by serum carotenoid concentrations, predicts reduced probability of polychlorinated biphenyl–associated risk for type 2 diabetes: National Health and Nutrition Examination Survey 2003-2004

Applicability of <i>in Vitro</i> Models in Predicting the <i>in Vivo</i> Bioavailability of Lycopene and <i>β</i>-Carotene from Differently Processed Soups

Consumption of Nutrients with Antioxidant Action and its Relationship with Lipid Profile and Oxidative Stress in Student Users of University Restaurant

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Effect of the consumption of a fruit and vegetable soup with high in vitro carotenoid bioaccessibility on serum carotenoid concentrations and markers of oxidative stress in young men

Cited by 18 publications

References 50 publications

Fruit and vegetable intake, as reflected by serum carotenoid concentrations, predicts reduced probability of polychlorinated biphenyl–associated risk for type 2 diabetes: National Health and Nutrition Examination Survey 2003-2004

Fruit and vegetable intake, as reflected by serum carotenoid concentrations, predicts reduced probability of polychlorinated biphenyl–associated risk for type 2 diabetes: National Health and Nutrition Examination Survey 2003-2004

Applicability of &lt;i&gt;in Vitro&lt;/i&gt; Models in Predicting the &lt;i&gt;in Vivo&lt;/i&gt; Bioavailability of Lycopene and &lt;i&gt;β&lt;/i&gt;-Carotene from Differently Processed Soups

Consumption of Nutrients with Antioxidant Action and its Relationship with Lipid Profile and Oxidative Stress in Student Users of University Restaurant

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Applicability of <i>in Vitro</i> Models in Predicting the <i>in Vivo</i> Bioavailability of Lycopene and <i>β</i>-Carotene from Differently Processed Soups