Effect of the configuration of poly(lactic acid) and content of poly(oxyethylene) blocks to the structure and functional properties of poly(lactic acid)‐block‐poly(oxirane)‐based nanofibrous electrospun polyester–ether–urethanes used as potential drug‐delivery system

Abstract

Poly(lactic acid)‐block‐poly(oxirane)s (PLA‐b‐POE) of various compositions were prepared using a one‐pot approach and then extended in a reaction with l‐lysine diethyl ester diisocyanate, thereby forming polyester–ether–urethanes (PEU) with prolonged chains and units with increased degradability. The PEUs are processed by electrospinning to prepare degradable nanofibrous sheet materials with and without encapsulating the antibiotic Vancomycin (VAC). PLA block isomerism and POE blocks oligomeric content (1000 g/mol) affect the thermal properties, processability, nanofibrous sheet morphology, abiotic degradation, cytocompatibility, and encapsulated antibiotic release rate of prepared PEUs. Therefore, our findings provide an effective approach to tuning the functional properties of these advanced biocompatible materials. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 107B: 2378–2387, 2019.

Threads Made with Blended Biopolymers: Mechanical, Physical and Biological Features

“…To date, there is no scientific study in the literature on the application of PLA/PCL/LTI blends as sutures. A good biological interaction of co-polyester-urethane networks from biodegradable polyesters and Lysine Isocyanate compounds has been proven by some other studies [23,24]. For these reasons, we started this characterization of our threads by tensile mechanical features correlated with a calorimetric and a morphological investigation, and finally, checking their bioactivity and antibacterial activity.…”

Precise Control of the Surface and Internal Morphologies of Porous Particles Prepared Using a Spontaneous Emulsification Method

“…Porous materials are used in a range of fields as drug delivery systems, − absorption agents, − and regeneration scaffolds. − Among the various forms of materials used in biomaterial fields, such as gels, sheets, and fibers, particles are of particular interest. Porous particles are produced using various methods, such as spray drying, − spray freeze drying, − and double emulsion–solvent evaporation. ,,− The double emulsion–solvent evaporation method is based on the precipitation of hydrophobic polymers contained in the droplets of water-in-oil-in-water (w/o/w) emulsions, which typically requires two-step mechanical emulsification.…”