Effect of the Composition and Structure of Excipient Emulsion on the Bioaccessibility of Pesticide Residue in Agricultural Products

Zhang, Ruojie; Wu, Wenhao; Zhang, Zipei; Park, Yeonhwa; He, Lili; Xing, Baoshan; McClements, David Julian

doi:10.1021/acs.jafc.7b02607

Cited by 21 publications

(12 citation statements)

References 48 publications

(98 reference statements)

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“…In addition to these areas, pyrazole derivatives have been successfully used in many fields such as pharmacy, agriculture, electronic industry, etc. They are used in a wide variety of agriculture industry as pesticides and insecticides agents and as pharmaceutical designers in industrial fields such as pharmacy and also are used in the technology industries to optical properties . For example, polymers containing pyrazole group are too useful for optoelectronic devices such as light emitting diodes and transistors due to low band gap …”

Section: Introductionmentioning

confidence: 99%

Some pyrazoles derivatives: Potent carbonic anhydrase, α‐glycosidase, and cholinesterase enzymes inhibitors

Türkan

Çetin

Taslimi

et al. 2018

Archiv der Pharmazie

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A series of substituteed pyrazol‐4‐yl‐diazene derivatives were found to be effective inhibitors against α‐glycosidase, cytosolic carbonic anhydrase I and II isoforms (hCA I and II), butyrylcholinesterase (BChE), and acetylcholinesterase (AChE) with Ki values in the range of 33.72 ± 7.93 to 90.56 ± 27.52 nM for α‐glycosidase, 1.06 ± 0.16 to 9.83 ± 0.74 nM for hCA I, 0.68 ± 0.12 to 7.16 ± 1.14 nM for hCA II, 44.66 ± 10.06 to 78.34 ± 17.83 nM for AChE, and 50.36 ± 13.88 to 88.36 ± 20.03 nM for BChE, respectively. Recently, inhibition of these metabolic enzymes has been considered as a promising factor for pharmacologic intervention in a diversity of disturbances, such as diabetes, glaucoma, obesity, epilepsy, cancer, and neurodegenerative diseases.

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Section: Introductionmentioning

confidence: 99%

Some pyrazoles derivatives: Potent carbonic anhydrase, α‐glycosidase, and cholinesterase enzymes inhibitors

Türkan

Çetin

Taslimi

et al. 2018

Archiv der Pharmazie

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“…Co-ingestion of emulsions with fruits and vegetables may therefore increase the bioavailability of undesirable pesticides, as well as any desirable nutraceuticals or vitamins. Indeed, in a previous study, we showed that oil-in-water emulsions could increase the bioaccessibility of hydrophobic pesticides on tomatoes . Moreover, we found that the efficacy of these emulsions at enhancing the bioaccessibility of the pesticides depended on their composition and structure.…”

Section: Introductionmentioning

confidence: 66%

“…The initial samples were passed through an in vitro simulated GIT model containing mouth, stomach, and small intestine phases, which has been described in detail in our previous study …”

Section: Methodsmentioning

confidence: 99%

Impact of Food Emulsions on the Bioaccessibility of Hydrophobic Pesticide Residues in Co-Ingested Natural Products: Influence of Emulsifier and Dietary Fiber Type

Zhang

et al. 2019

J. Agric. Food Chem.

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In the typical Western diet, fruits and vegetables are often consumed with food products that exist as oil-in-water emulsions, such as creams, dressings, and sauces. Studies have shown that coingestion of fruits and vegetables with emulsions can increase the bioavailability of beneficial lipophilic bioactive agents, such as nutraceuticals or vitamins. Agricultural produce, however, may also be contaminated with low levels of detrimental lipophilic agents, such as hydrophobic pesticides. We therefore examined the impact of coingesting a common agricultural product (tomatoes) with model food emulsions on the bioaccessibility of a hydrophobic pesticide (chlorpyrifos). The impact of emulsifier types (phospholipids, whey protein, Tween 80) and dietary fiber types (xanthan, chitosan, β-glucan) on the bioaccessibility of the pesticide was measured using a simulated gastrointestinal model. Chlorpyrifos bioaccessibility depended on the type of emulsifier used to formulate the emulsions: phospholipids > Tween 80 > whey protein. Dietary fiber type also influenced pesticide bioaccessibility by an amount that depended on the nature of the emulsifier used. Overall, our results suggest that the bioaccessibility of undesirable pesticides on fruits and vegetables will depend on the nature of the emulsions they are consumed with.

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“…Pesticides are commonly applied to fruits and vegetables during their growth and/or postharvest processing [20][21][22]. Previously, we demonstrated that mixing emulsions with tomatoes prior to digestion increased the bioaccessibility of chlorpyrifos, a non-polar pesticide [23]. As mentioned earlier, the digestion of oil droplets results in the production of mixed micelles within the gastrointestinal fluids, which solubilize any non-polar substances and carry them to the intestinal lining where they can be absorbed [10,11].…”

Section: Introductionmentioning

confidence: 80%

“…Three representative pesticides with different Log P values were examined: Bendiocarb (Log P = 1.7); parathion (Log P = 3.8); and chlorpyrifos (Log P = 5.3). The bioaccessibilities of the pesticides were measured after the samples were passed through a simulated gastrointestinal tract (GIT) [23]. Samples containing different amounts of oil droplets (0%, 4%, and 8%) were used to study the impact of the oil content of emulsion-based foods on pesticide bioaccessibility.…”

Section: Introductionmentioning

confidence: 99%

Impact of Pesticide Type and Emulsion Fat Content on the Bioaccessibility of Pesticides in Natural Products

Zhang

et al. 2020

Molecules

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There is interest in incorporating nanoemulsions into certain foods and beverages, including dips, dressings, drinks, spreads, and sauces, due to their potentially beneficial attributes. In particular, excipient nanoemulsions can enhance the bioavailability of nutraceuticals in fruit- and vegetable-containing products consumed with them. There is, however, potential for them to also raise the bioavailability of undesirable substances found in these products, such as pesticides. In this research, we studied the impact of excipient nanoemulsions on the bioaccessibility of pesticide-treated tomatoes. We hypothesized that the propensity for nanoemulsions to raise pesticide bioaccessibility would depend on the polarity of the pesticide molecules. Bendiocarb, parathion, and chlorpyrifos were therefore selected because they have Log P values of 1.7, 3.8, and 5.3, respectively. Nanoemulsions with different oil contents (0%, 4%, and 8%) were fabricated to study their impact on pesticide uptake. In the absence of oil, the bioaccessibility increased with increasing pesticide polarity (decreasing Log P): bendiocarb (92.9%) > parathion (16.4%) > chlorpyrifos (2.8%). Bendiocarb bioaccessibility did not depend on the oil content of the nanoemulsions, which was attributed to its relatively high water-solubility. Conversely, the bioaccessibility of the more hydrophobic pesticides (parathion and chlorpyrifos) increased with increasing oil content. For instance, for chlorpyrifos, the bioaccessibility was 2.8%, 47.0%, and 70.7% at 0%, 4%, and 8% oil content, respectively. Our findings have repercussions for the utilization of nanoemulsions as excipient foods in products that may have high levels of undesirable non-polar substances, such as pesticides.

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Effect of the Composition and Structure of Excipient Emulsion on the Bioaccessibility of Pesticide Residue in Agricultural Products

Cited by 21 publications

References 48 publications

Some pyrazoles derivatives: Potent carbonic anhydrase, α‐glycosidase, and cholinesterase enzymes inhibitors

Some pyrazoles derivatives: Potent carbonic anhydrase, α‐glycosidase, and cholinesterase enzymes inhibitors

Impact of Food Emulsions on the Bioaccessibility of Hydrophobic Pesticide Residues in Co-Ingested Natural Products: Influence of Emulsifier and Dietary Fiber Type

Impact of Pesticide Type and Emulsion Fat Content on the Bioaccessibility of Pesticides in Natural Products

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