Effect of the combination of mexidol and diclofenac sodium on exudative inflammation in rats after ten-day preventive oral administration

Abstract

In rats with carrageenan-induced paw edema, diclofenac sodium significantly reduces exudation after ten-day preventive oral administration at a dose of 10 mg/kg but not 5 mg/kg. Mexidol at a dose of 100 mg/kg in combination with diclofenac sodium at a dose of 5 mg/kg (preventively orally, during 10 days, once a day) reduces paw edema during the first two out of four hours of its recording compared with the control group. However, ten-day preventive oral administration of mexidol at a dose of 100 mg/kg (once a day) increases the severity of carrageenan-induced paw edema in rats at four hours after the injection of the phlogogen.

Multicomponent Photocomposition as A Source for Development New Anti-Inflammatory Medicines

“…It was interesting to compare the activity of the studied phytocompositions with the phytopreparation -canefron [9], which reduced the degree of edema by 24.0%, and the anti-inflammatory activity was 28.2% in our studies. The obtained results were also compared with the effect of the gold standard NSAID -diclofenac sodium [10], which under the conditions of our experiment suppressed the development of aseptic inflammation by 42.4% compared with the control group and the value of anti-inflammatory activity was 39.8%. Therefore, the studied new phytocompositions have distinct anti-edematous effects in the model of dextran-induced aseptic arthritis.…”

Study of the anti-inflammatory, analgesic, ulcerogenic and anti-ulcerogenic activity of N-isopropenylimidazole zinc complex derivative

“…Furthermore, Bystrova et al (2021) suggest that histamine and its receptors may function as parts of signaling pathways connected to the development of inflammatory and pain responses and that through a histamine-dependent mechanism, toll-like receptors (TLRs) may control the expression pattern of TRPV1 receptors on sensory neurons, which are important for nociception and inflammation. It has recently been shown that diclofenac decreases the blood plasma histamine concentration, but has no effect on the serotonin level or the histamine and serotonin content of peritoneal exudates in rats with experimental acetic peritonitis, which is accompanied by a significant increase in the concentrations of histamine and serotonin in blood plasma (Ivanova and Voronina, 2018;Beskhmelnitsyna et al 2019). Based on the above data, it is possible that the antiinflammatory and analgesic effect of Pilim-1 is also associated with impaired histamine production.…”