Effect of the coexposure of sulfadiazine, ciprofloxacin and zinc on the fate of antibiotic resistance genes, bacterial communities and functions in three-dimensional biofilm-electrode reactors

Response behavior of antibiotic resistance genes to zinc oxide nanoparticles in cattle manure thermophilic anaerobic digestion process: A metagenomic analysis

“…It is observed that relative abundances of ARGs for tetracycline fosfomycin, mupirocin could be decreased in the presence of ZnO NPs, while ARGs for nitromidazole increased. These variety in the relative abundance of different ARGs was also reported previously and led to inconsistent conclusions due to mainly the application of different experimental conditions, such as the environmental matrix and the duration and dose of zinc exposure (Li et al, 2020a;Li et al, 2020b). The decreased ARGs belonging to category I in G1 (Figure 2b) might have resulted from the blockage on antibiotic resistance induced by ZnO NPs, since zinc has been found to be an inhibitor on SOS-induced hypermutation to rifampin antibiotic in Escherichia coli, and then on SOS-response-related horizontal transfer of ARGs (Crane et al, 2018).…”

“…Zinc is one of the most popular components used as animal food supplement to improve livestock growth. In particular, zinc oxide nanoparticles (ZnO NPs), which are known to have better bioavailability than bulk ZnO, have been recently applied as feed additives in livestock industry (Fawzy et al, 2021;Li et al, 2020a), and part of these nanoparticles eventually end up in livestock manure. It has been pointed out that Zn concentration in livestock manure can range from 39.5 to 11379.0 mg/kg dry weight (Li et al, 2020c).…”

“…Currently, many efforts have been made to clarify the role of ZnO NPs in ARGs' behavior, but findings are inconsistent mainly due to the different matrices and processes assayed. For example, on the one hand it was observed that zinc could promote the abundance propagation of ARGs in various processes, such as in a three-dimensional biofilm-electrode reactor (Li et al, 2020a), in co-composting swine manure and cotton stalks (Zhang et al, 2018), and over bacterial exposure (Otinov et al, 2020). On the other hand, Li et al (2020b) pointed out that excessive zinc concentration could lead to a decline in the abundance of total ARGs.…”

Current Progress in Natural Degradation and Enhanced Removal Techniques of Antibiotics in the Environment: A Review

“…Guo and colleagues found significant removal of chloramphenicol at lower chloramphenicol concentrations and high cathode potentials while at intermediate cathode potentials, both enrichment of chloramphenicol-resistant bacteria and the expression of ARGs were suppressed [ 146 ]. A study by Li et al utilized a three-dimensional biofilm electrode reactor (activated sludge of wastewater treatment plant) to investigate the removal of sulfonazine, ciprofloxacin, and zinc from wastewater, and showed that the reactor not only had the ability to eliminate both antibiotics and zinc but also greatly reduced the risk of ARG transmission by removing the intI 1 gene in wastewater [ 147 ]. Xue et al reported that more than 85% of sulfamethoxazole was degraded within 60 h, which may have been due to the continuous electrical stimulation or the metabolism of microorganisms.…”

Seasonal variations of microbial community structure, assembly processes, and influencing factors in karst river

“…With increasing human activities, the constant input of nitrogen, phosphorus and emerging pollutants such as antibiotics had disrupted the physicochemical properties, the structure and interactions of microbial communities, as well as their carbon and nitrogen cycles ( Zhang et al, 2013 ; Xi et al, 2015 ; Mahana et al, 2016 ; Zhernakova et al, 2016 ; Subirats et al, 2019 ; Roose-Amsaleg et al, 2021 ). Not only had antibiotics affected the microbial community structure, but also influenced their metabolic mechanisms, such as carbon sequestration, nitrification and denitrification ( Gonzalez-Martinez et al, 2014 ; Xiong et al, 2015 ; Li H. et al, 2020 ; Slipko et al, 2021 ). Different bacteria acquired resistance genes variously under the selection pressure caused by antibiotics, which regulated their metabolic strategies and the efficiency of element cycles ( Ming et al, 2020 ; Yang et al, 2020 ; Zhang et al, 2022 ).…”