Effect of the Center Post Establishment and Its Design Variations on the Performance of a Centrifugal Rotary Blood Pump

Fang, Peng; Du, Jianjun; Yu, Shunzhou

doi:10.1007/s13239-020-00464-0

Cited by 5 publications

(4 citation statements)

References 32 publications

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“…Specific design features of the HM3 pump core include no central post and large gaps. Consistent with the results of Fang et al ( 32 ) and Wiegmann et al ( 18 ), the absence of central post leads to the formation of a flow stagnation region centrally below the rotor under baseline conditions. This stagnation region was completely eradicated by flow reversal during the low-speed phase of the AP.…”

Section: Discussionsupporting

confidence: 89%

Insights Into the Low Rate of In-Pump Thrombosis With the HeartMate 3: Does the Artificial Pulse Improve Washout?

Fang

Boraschi

et al. 2022

Front. Cardiovasc. Med.

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While earlier studies reported no relevant effect of the HeartMate 3 (HM3) artificial pulse (AP) on bulk pump washout, its effect on regions with prolonged residence times remains unexplored. Using numerical simulations, we compared pump washout in the HM3 with and without AP with a focus on the clearance of the last 5% of the pump volume. Results were examined in terms of flush-volume (Vf, number of times the pump was flushed with new blood) to probe the effect of the AP independent of changing flow rate. Irrespective of the flow condition, the HM3 washout scaled linearly with flush volume up to 70% washout and slowed down for the last 30%. Flush volumes needed to washout 95% of the pump were comparable with and without the AP (1.3–1.4 Vf), while 99% washout required 2.1–2.2 Vf with the AP vs. 2.5 Vf without the AP. The AP enhanced washout of the bend relief and near-wall regions. It also transiently shifted or eliminated stagnation regions and led to rapid wall shear stress fluctuations below the rotor and in the secondary flow path. Our results suggest potential benefits of the AP for clearance of fluid regions that might elicit in-pump thrombosis and provide possible mechanistic rationale behind clinical data showing very low rate of in-pump thrombosis with the HM3. Further optimization of the AP sequence is warranted to balance washout efficacy while limiting blood damage.

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Section: Discussionsupporting

confidence: 89%

Insights Into the Low Rate of In-Pump Thrombosis With the HeartMate 3: Does the Artificial Pulse Improve Washout?

Fang

Boraschi

et al. 2022

Front. Cardiovasc. Med.

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“…Compared to HM3, one geometrical difference is the Corheart's central post below the rotor. Fang et al 25 found that the central post mainly affected the flow stagnation region centrally below the rotor. The low‐velocity zone under constant rotor speed, a scenario present in the HM3 (Figure 6, region II), does not appear in the Corheart.…”

Section: Discussionmentioning

confidence: 99%

Preclinical evaluation of the fluid dynamics and hemocompatibility of the Corheart 6 left ventricular assist device

Fang

Yang²,

Wei

et al. 2023

Artificial Organs

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Background Corheart 6 (Corheart) is a newly developed magnetically levitated continuous‐flow left ventricular assist device currently undergoing multicenter clinical trials in China. Featuring a small size, minimal weight, and low power consumption, the Corheart aims to improve pump hemocompatibility, reduce adverse events, and enhance the quality of life of heart failure patients. Methods Computational simulations assessed flow field, shear stress, and washout, while in vitro and in vivo experiments were performed to further demonstrate hemocompatibility. Results Numerical results show that the flow path in the Corheart blood pump is well designed. There is no significantly high shear stress in the majority of the flow domain. Short secondary flow paths and small pump size (small priming volume) provide good washing (0.049 and 0.165 s to remove 55% and 95% old blood, respectively), allowing low hemolysis levels both in computational and in vitro hemolysis tests (in vitro hemolysis index ranges from 0.00092 ± 0.00006 g/100 L to 0.00134 ± 0.00019 g/100 L). Good hemocompatibility was further evidenced by ten 60‐day sheep implants tested with relatively low flow rates of 2.0 ± 0.2 L/min; the results showed no hemolysis or thrombosis. Conclusions Numerical and experimental results shed light on the fluid dynamics characteristics and hemocompatibility of the Corheart. It is believed that the Corheart will provide more promising possibilities for minimally invasive implantation techniques and for those patients with a small body surface area.

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“…The results show that the rotating speed of the impeller has the greatest influence on the performance. In order to study the effect of center post establishment and its parameter changes on the performance of centrifugal blood pumps, Fang et al 11 used CFD to analyze the internal flow of blood pumps with different central posts in the extensive parametric approach, and RNG k -ε model was selected as the turbulence model. Fan et al 12 used the k- ω turbulence model to analyze the internal flow of the axial flow blood pump based on the established numerical method.…”

Section: Introductionmentioning

confidence: 99%

Analysis of the flow field characteristics of a centrifugal blood pump in a heartbeat cycle

Zhang,

Yang,

Shao

2024

Advances in Mechanical Engineering

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Blood pumps are medical devices that can temporarily or permanently replace the heart to perform the job of blood pumping. To study the internal flow field characteristics of the centrifugal blood pump, high-speed photography (HSP) images of the internal flow in the centrifugal blood pump were taken, and the internal flow field was numerically simulated. According to the heartbeat rule, the visualization experiment method and numerical simulation method for the internal flow of the centrifugal blood pump were developed. The internal flow rule of the centrifugal blood pump during a heartbeat cycle was revealed, as well as the influence of pump construction, flow rate, and other factors on the pump’s flow field. The results indicate that the flow rate and the rotor/stator interference of the blade and volute tongue cause two periodic changes in the pump pressure and velocity. One is the cycle of the heartbeat, and the other is the cycle of the blade’s rotation. The research results are of great significance in reducing the mechanical damage of blood, optimizing the structure of the pump and improving the stability of the centrifugal blood pump.

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Effect of the Center Post Establishment and Its Design Variations on the Performance of a Centrifugal Rotary Blood Pump

Cited by 5 publications

References 32 publications

Insights Into the Low Rate of In-Pump Thrombosis With the HeartMate 3: Does the Artificial Pulse Improve Washout?

Insights Into the Low Rate of In-Pump Thrombosis With the HeartMate 3: Does the Artificial Pulse Improve Washout?

Preclinical evaluation of the fluid dynamics and hemocompatibility of the Corheart 6 left ventricular assist device

Analysis of the flow field characteristics of a centrifugal blood pump in a heartbeat cycle

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