Effect of the bovine TG5 gene polymorphism on milk- and meat-producing ability

Dolmatova, I. Yu.; Седых, Т. А.; Valitov, F.R.; Gizatullin, R. S.; Khaziev, Danis; Kharlamov, Anatoly V

doi:10.14202/vetworld.2020.2046-2052

Cited by 8 publications

(5 citation statements)

References 16 publications

(20 reference statements)

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“…Several studies have reported the association of MASP2, TG5, and DQA1genes polymorphism with production and components in cattle (Al-Waith et al, 2018;Zhang et al, 2019;Dolmatova et al, 2020). However, unlike our study, all of these studies investigated the association of gene polymorphism in only one breed of cattle.…”

Section: Discussionmentioning

confidence: 67%

“…Moreover, thyroid hormones influence lipid metabolism and adipocyte development into adipose tissue. Consequently, the thyroglobulin gene is a functional and positional candidate gene that influences fat accumulation in tissues, including milk (Dolmatova et al, 2020). A single-nucleotide polymorphism in the 5′ untranslated region of the TG5 gene is used for marker-based selection targeted at raising marbling (Carvalho et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

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Genetic polymorphisms of MASP2, TG5, and DQA1 genes in Holstein and Brown Swiss dairy cows

Zeer

Fouda

Darwish

2023

J Hellenic Vet Med Soc

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The objective of this study was to investigate polymorphisms of MASP2, TG5 and DQA1 genes using PCR-DNA sequencing in seventy Holstein, and Brown Swiss dairy cows (35 cows each). Under complete aseptic condition, blood samples were collected from each animal into tubes containing disodium EDTA as an anticoagulant for DNA extraction. PCR was carried out for amplification of 305-bp of MASP2, 545-bp of TG5, and 373-bp of DQA1 genes. DNA sequencing assessment elaborated nucleotide sequence variations in forms of single nucleotide polymorphisms (SNPs) between two breeds. The SNPs identified in the investigated genes for Holstein breed were A46G in MASP2 gene and C371T in TG5 gene. A characteristic T53C SNP was also reported for Brown Swiss breed in DQA1 gene. Chi-square revealed a significant variation in distribution of all identified SNPs (P < 0.001). Consequently, identified SNPs could be used as candidates and a reference guide for efficient characterization of Holsteins, and Brown Swiss breeds; therefore, developing a marker assisted selection (MAS) for production and immunity traits in breeds of dairy cattle.

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Section: Discussionmentioning

confidence: 67%

Section: Introductionmentioning

confidence: 99%

Genetic polymorphisms of MASP2, TG5, and DQA1 genes in Holstein and Brown Swiss dairy cows

Zeer

Fouda

Darwish

2023

J Hellenic Vet Med Soc

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“…Hormone release occurs due to the stimulation of the thyroid cells by the thyrotropic hormone (TSH). Further activity by the released hormones stimulates the hepatic processes of gluconeogenesis and lipogenesis, as well as the occurrence of glycogenolysis [ 62 ].…”

Section: Thyroglobulinmentioning

confidence: 99%

Polymorphism of Genes and Their Impact on Beef Quality

Kostusiak

Slósarz

Gołębiewski

et al. 2023

CIMB

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The single-nucleotide polymorphism (SNP) form of genes is a valuable source of information regarding their suitability for use as specific markers of desirable traits in beef cattle breeding. For several decades, breeding work focused on improving production efficiency through optimizing the feed conversion ratio and improving daily gains and meat quality. Many research teams previously undertook research work on single-nucleotide polymorphism in myostatin (MSTN), thyroglobulin (TG), calpain (CAPN), and calpastatin (CAST) proteins. The literature review focuses on the most frequently addressed issues concerning these genes in beef cattle production and points to a number of relevant studies on the genes’ polymorphic forms. The four genes presented are worth considering during breeding work as a set of genes that can positively influence productivity and production quality.

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“…Nevertheless, the fat content and FA composition of beef remain important characteristics for both producers and consumers [ 9 ]. Many researchers have identified polymorphisms in the leptin ( LEP ) and thyroglobulin ( TG5 ) genes as significant genetic factors that influence the intensity and characteristics of fat metabolism in the body [ 10 , 11 ]. Thus, the C422T polymorphism occurs in the 5’-promoter region of the TG5 gene [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Effect of TG5 and LEP polymorphisms on the productivity, chemical composition, and fatty acid profile of meat from Simmental bulls

Sycheva,

Latynina,

Mamedov

et al. 2023

Vet World

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Background and Aim: Enhancing the nutritional and biological value of meat obtained from young surplus replacement animals of dual-purpose breeds is a critical objective in the livestock industry. This study aimed to investigate the impact of thyroglobulin (TG5, c. −422C > T) and leptin (LEP, c. 239C > T) polymorphisms on the productivity, chemical composition, and fatty acid (FA) profile of meat from Simmental bulls. Materials and Methods: A total of 26 Simmental bulls were genotyped for TG5 (c. −422C > T) and LEP (c. 239C > T) polymorphisms and reared under the same fattening conditions. Controlled slaughter was conducted at 18 months of age. Subsequently, the experimental animals were evaluated to determine their slaughter traits and the chemical and FA composition of ground beef and the longissimus dorsi muscle. Results: The results showed that the TG5 (c. −422C > T) polymorphism significantly (p < 0.05) affected the differentiation of bulls in terms of the synthesis of stearic acid, linolenic acid, and total polyunsaturated FAs, as well as the fat and dry matter content in the longissimus dorsi muscle. Conversely, the presence of the T allele in the LEP (c. 239C > T) polymorphism was associated with increased dry matter and fat in ground beef, carcass weight, and internal fat weight. Conclusion: The analysis of slaughter traits and the chemical and FA composition of meat from the Simmental bulls genotyped for the TG5 and LEP genes revealed a genetic basis for the quantitative and qualitative characteristics of meat productivity. Thus, the genetic variability of bulls regarding the LEP and TG5 genes can be used to improve the quantitative and qualitative indicators of meat productivity in Simmental cattle through marker-assisted selection. Keywords: chemical composition, fatty acid, leptin, meat productivity, polymorphism, Simmental, thyroglobulin.

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Effect of the bovine TG5 gene polymorphism on milk- and meat-producing ability

Cited by 8 publications

References 16 publications

Genetic polymorphisms of MASP2, TG5, and DQA1 genes in Holstein and Brown Swiss dairy cows

Genetic polymorphisms of MASP2, TG5, and DQA1 genes in Holstein and Brown Swiss dairy cows

Polymorphism of Genes and Their Impact on Beef Quality

Effect of TG5 and LEP polymorphisms on the productivity, chemical composition, and fatty acid profile of meat from Simmental bulls

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