Effect of the Aqueous Extract of <i>Schumanniophyton magnificum</i> Harms on Sexual Maturation and Fertility of Immature (K. schum) Female Rat

Abstract

The aim of the study was to bring scientific evidence of the curative action of the stem bark aqueous extract of Schumanniophyton magnificum (ASMa) on the sexual maturation and fertility of the immature female Wistar rat. Forty immature female rats were randomized and divided into 4 groups of ten animals each and orally treated with the ASMa at doses of 0 (distilled water), 200 mg/kg, 400 mg/kg and 800 mg/kg /BW/day for 30 consecutive days. Body weight and food intake were recorded throughout the experimental period. The precocity of the puberty onset in treated animals was evaluated through the determination of their age at vaginal opening. At the end of the experimental period, 5 animals in each group were sacrificed and blood samples were collected for hormonal assay. Their ovaries and uteri were removed, blotted, weighted and prepared for biochemical analysis. The remaining rats (5 per group) were crossed with males of proven fertility. After laparotomy (ten days after mating) and delivery, fertility and gestational parameters were recorded. It was noticed that, body weight gain increased significantly at all doses although there was no significant difference in food intake. The sexual maturation of treated animal was reduced to 5 days when compared to control. This was associated with the simultaneous elevation of FSH and LH (p < 0.0001) at dose of 800 mg/kg and FSH alone (p < 0.001) at dose of 400 mg/kg. However, the ovarian cholesterol significantly decreased (p < 0.0001) at all doses while the uterine protein significantly increased (p < 0.05; p < 0.0001) respectively at dose of 400 mg/kg and 800 mg/kg. The animal treated at doses

Assessment of in vivo estrogenic and anti-inflammatory activities of the hydro-ethanolic extract and polyphenolic fraction of parsley (Petroselinum sativum Hoffm.)

“…Here, uterine protein determination revealed that our extracts exhibit a positive effect on uterine proteins synthesis. Similarly, other researchers have demonstrated the positive effects of estrogenic substances in increasing proteins level (Bend et al, 2018;Lee and Lee, 1996).…”

Effect of the Aqueous Stem Bark Extract of &lt;i&gt;Schumanniophyton magnificum&lt;/i&gt; on Reproductive Functions on Wistar Strain Mature Female Rats

“…In Cameroon, Schumanniophyton magnificum has been recognized as a plant relieving infertile women. Subsequent studies have shown the accelerating and stimulating effect of Schumanniophyton magnificum on the growth and fertility of immature rats [6]. Recent phytochemical studies revealed the presence of secondary metabolites, such as flavonoids, alkaloids, polyphenols and steroids [7] [8].…”

Bioassay-guided fractionation, phospholipase A2-inhibitory activity and structure elucidation of compounds from leaves of Schumanniophyton magnificum

“… 2007 ), and ability of the stem bark aqueous extract to improve fertility has also been demonstrated (Bend et al. 2018 ). S. magnificum is used as a snake bite remedy and as snake repellent in Nigeria.…”

“…Its stem bark is also used in Congo as an antiseptic for the treatment of gonorrhoea and ulcers. The stem bark extracts are also effective against Plasmodium falciparum (Bickii et al 2007), and ability of the stem bark aqueous extract to improve fertility has also been demonstrated (Bend et al 2018). S. magnificum is used as a snake bite remedy and as snake repellent in Nigeria.…”