Effect of the aggregation state of amorphous calcium phosphate on hydroxyapatite nucleation kinetics

Jiang, Shuqin; Jin, Wenjing; Wang, Yanan; Pan, Haihua; Sun, Zhiwei; Tang, Ruikang

doi:10.1039/c7ra02208e

Cited by 41 publications

(43 citation statements)

References 43 publications

(55 reference statements)

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“…To keep the ionic product of ACP, {Ca 2+ } needs to be increased, which can promote the ACP-mediated crystallization ( Figure 8). This model can also be applied to explain the stability change of ACP by its aggregation state [86] and its size [85]. It should be noted that our model is applicable when a crystal phase is nucleated directly from an amorphous phase.…”

Section: Amorphous Phase Mediated Nucleationmentioning

confidence: 99%

“…This model can also be applied to explain the stability change of ACP by its aggregation state [86] and its size [85]. system, the effective supersaturation can be taken as a constant regardless of how much calcium and phosphate ions were initially put into solution.…”

Section: Amorphous Phase Mediated Nucleationmentioning

confidence: 99%

“…The surface area of ACP and the activity of calcium ions in solution are the key factors for controlling nucleation kinetics [6,7]. Citrate [84], poly-Asp [11], silicate [85], solution pH [10], and the aggregation stated of ACP [86] can either modify the ACP surface or the surface area or change the activity of calcium in solution that leads to the inhibition or promotion of ACP phase transformation. In addition to the surface-mediated nucleation pathway, ACP-HAP crystallization might also go through other pathways, such as multiple sites nucleation inside ACP [58], HAP nucleation at ACP inter-particles boundary [87], and structure-rearrangement of the Ca 9 (PO 4 ) 6 unit (called Posner cluster) in ACP [33,61], which indicate that the CaP crystallization pathway is solution chemical-sensitive.…”

Section: Mineralization Mediummentioning

confidence: 99%

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Amorphous Phase Mediated Crystallization: Fundamentals of Biomineralization

et al. 2018

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Many biomineralization systems start from transient amorphous precursor phases, but the exact crystallization pathways and mechanisms remain largely unknown. The study of a well-defined biomimetic crystallization system is key for elucidating the possible mechanisms of biomineralization and monitoring the detailed crystallization pathways. In this review, we focus on amorphous phase mediated crystallization (APMC) pathways and their crystallization mechanisms in bio-and biomimetic-mineralization systems. The fundamental questions of biomineralization as well as the advantages and limitations of biomimetic model systems are discussed. This review could provide a full landscape of APMC systems for biomineralization and inspire new experiments aimed at some unresolved issues for understanding biomineralization.

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Section: Amorphous Phase Mediated Nucleationmentioning

confidence: 99%

Section: Amorphous Phase Mediated Nucleationmentioning

confidence: 99%

Section: Mineralization Mediummentioning

confidence: 99%

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Amorphous Phase Mediated Crystallization: Fundamentals of Biomineralization

et al. 2018

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“…The formation of brushite or amorphous Ca-phosphates (ACP) can be ruled out based on X-ray diffraction data. Brushite typically exhibits diffraction peaks at 11.6°and 20.6°(RRUFF R070554) and the formation of ACP is characterized by a diffusive broad peak between 27°and 37° (Posner and Betts, 1975;Sauer and Wuthier, 1988;Gadaleta et al, 1996;Dorozhkin, 2009;Jiang et al, 2017). Thus, we conclude that the precipitates are Ca-deficient and are most likely formed of non-stoichiometric HAP or OCP rather than other Ca-phosphates such as brushite or ACP.…”

Section: àmentioning

confidence: 81%

Mineralogical, nanostructural, and Ca isotopic evidence for non-classical calcium phosphate mineralization at circum-neutral pH

Schilling

Brown

Lammers

2018

Geochimica et Cosmochimica Acta

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Growth pathways of calcium (Ca) phosphate minerals are still under debate, but non-classical growth pathways, which encompass any mode of growth involving attachment of primary particles instead of monomer ions, are currently thought to dominate over classical mechanisms under a wide range of growth conditions. Cation desolvation during ion-by-ion growth is associated with the preferential uptake of isotopically light Ca in Ca-bearing phases, so the Ca isotope composition of Cabearing minerals can help to elucidate the dominant growth mechanism. Here, we combine stable Ca isotope analysis with mineralogical characterization and nanoscale imaging of growth features to determine for the first time the rate-dependent Ca isotope fractionation during seeded growth of hydroxyapatite (HAP) involving an octacalcium phosphate (OCP) precursor. Our data reveal that growth rates are strongly attenuated by pH, and that Ca isotope fractionation between the solid and growth solution is independent of growth rate between 1.9 Â 10 À9 and 2.8 Â 10 À8 mol Ca m À2 s À1. Moreover, nanoscale images of surface topography reveal direct deposition of primary particles on the HAP seed surface following sustained growth, providing visual evidence of a non-classical growth pathway. Together, these findings support the hypothesis that hydroxyapatite growth is dominantly non-classical. The process of cluster nucleation from the bulk solution and attachment of these clusters to the seeded HAP apparently does not involve a significant kinetic isotope effect, which implies that abiogenically formed Ca-phosphates likely preserve the Ca isotope composition of the fluid from which the crystals originated.

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“…The aggregation state of ACP is among the key factors determining its further transformation [2,28,29]. Compared to aggregation of nanoparticles, aggregation of ACP is a more complex process that proceeds simultaneously at significantly different length scales.…”

Section: Introductionmentioning

confidence: 99%

Amorphous Calcium Phosphate Formation and Aggregation Process Revealed by Light Scattering Techniques

et al. 2018

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Amorphous calcium phosphate (ACP) attracts attention as a precursor of crystalline calcium phosphates (CaPs) formation in vitro and in vivo as well as due to its excellent biological properties. Its formation can be considered to be an aggregation process. Although aggregation of ACP is of interest for both gaining a fundamental understanding of biominerals formation and in the synthesis of novel materials, it has still not been investigated in detail. In this work, the ACP aggregation was followed by two widely applied techniques suitable for following nanoparticles aggregation in general: dynamic light scattering (DLS) and laser diffraction (LD). In addition, the ACP formation was followed by potentiometric measurements and formed precipitates were characterized by Fourier transform infrared spectroscopy (FTIR), powder X-ray diffraction (PXRD), transmission electron microscopy (TEM), and atomic force microscopy (AFM). The results showed that aggregation of ACP particles is a process which from the earliest stages simultaneously takes place at wide length scales, from nanometers to micrometers, leading to a highly polydisperse precipitation system, with polydispersity and vol. % of larger aggregates increasing with concentration. Obtained results provide insight into developing a way of regulating ACP and consequently CaP formation by controlling aggregation on the scale of interest.

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Effect of the aggregation state of amorphous calcium phosphate on hydroxyapatite nucleation kinetics

Abstract: In the ACP-mediated HAP nucleation pathway, the nucleation rate of HAP increases when ACP is in the separated state.

Cited by 41 publications

References 43 publications

Amorphous Phase Mediated Crystallization: Fundamentals of Biomineralization

Amorphous Phase Mediated Crystallization: Fundamentals of Biomineralization

Mineralogical, nanostructural, and Ca isotopic evidence for non-classical calcium phosphate mineralization at circum-neutral pH

Amorphous Calcium Phosphate Formation and Aggregation Process Revealed by Light Scattering Techniques

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