Effect of the aggregated protein dye YAT2150 on
Leishmania
parasite viability
Lucía Román-Álamo,
Yunuen Avalos-Padilla,
Inés Bouzón-Arnáiz
et al.
Abstract:The problems associated with the drugs currently used to treat leishmaniasis, including resistance, toxicity, and the high cost of some formulations, call for the urgent identification of new therapeutic agents with novel modes of action. The aggregated protein dye YAT2150 has been found to be a potent antileishmanial compound, with a half-maximal inhibitory concentration (IC
50
) of approximately 0.5 µM against promastigote and amastigote stages of
Leishmania infantum… Show more
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