Effect of the adrenergic neurone blocker, ?-TM 10, on the depletion of noradrenaline induced by denervation or reserpine

Hennemann, H; Trendelenburg, U.

doi:10.1007/bf00997194

Cited by 10 publications

(2 citation statements)

References 11 publications

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“…It is interesting to note that the secretion occurs within the period during which the transmitter vanishes from the gland (Benmiloud & Euler, 1963;Hennemann & Trendelenburg, 1970). It is obvious that during that period at least some of the noradrenaline is not destroyed in the degenerating axons but is released and reaches the effector cells.…”

Section: Resultsmentioning

confidence: 99%

Degeneration secretion of saliva in the rat following sympathectomy

Delfs¹,

Emmelin²

1974

The Journal of Physiology

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SUMMARY1. After previous extirpation of the superior cervical ganglion saliva was found to flow from the cannulated submaxillary duct of rats under chloralose anaesthesia. The secretion started 13-14'5 hr after sympathectomy, increased gradually in rate and then slowed down and ceased, lasting for about 12 hr.2. Injection of ax-or /-adrenoreceptor blocking drugs reduced the flow and a combination of both types of drugs abolished it. It is concluded that the secretion was caused by noradrenaline released from the degenerating nerves, and that the phenomenon is an example of the degeneration activity described in other preparations as an effect of section of postganglionic autonomic nerves.3. A similar, but less pronounced, secretion was found in the parotid gland of the rat.

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Section: Resultsmentioning

confidence: 99%

Degeneration secretion of saliva in the rat following sympathectomy

Delfs¹,

Emmelin²

1974

The Journal of Physiology

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“…This is due to the fact that salivary glands are rich in adrenergic nerve endings [4,6,16] and that they have a high content of norepinephrine [1,11,22] which induces the formation of glandular cAMP. In arterial hypertensive diseases the cAMP excretion rate in saliva is increased in man [17] and renovascular hypertensive rats (Schmid et al, unpublished data).…”

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confidence: 99%

Technique of continuous collection of parotid saliva in the rat

et al. 1978

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A method is described, which is suitable to collect continuously and quantitatively saliva from both parotid glands in rats under in vivo conditions and which allows to investigate salivary electrolyte composition in relation to flow rate during several hours. This might be of expanding scientific interest in disturbances of transepithelial electrolyte transport in various pathophysiological situations (for instance different forms of experimental hypertension, endstage renal failure and so on).

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Degeneration activity after parasympathetic or sympathetic denervation

Emmelin¹,

Trendelenburg

1972

Ergebnisse Der Physiologie Reviews of Physiology, Volume 66

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Effect of the adrenergic neurone blocker, ?-TM 10, on the depletion of noradrenaline induced by denervation or reserpine

Cited by 10 publications

References 11 publications

Degeneration secretion of saliva in the rat following sympathectomy

Degeneration secretion of saliva in the rat following sympathectomy

Technique of continuous collection of parotid saliva in the rat

Degeneration activity after parasympathetic or sympathetic denervation

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