Effect of thalidomide dithiocarbamate analogs on the intercellular adhesion molecule-1 expression

Cereblon binding molecules in multiple myeloma

“…CBMs can alter this cross talk between MM and bone marrow stroma cells (BMSCs) [33,34], by downregulation of various cell surface adhesion molecules [35][36][37][38][39][40][41][42][43] leading to reduced cell-cell interactions and altered cell migration [44]. CBMs decrease the osteoclast (OC) growth and survival factor MIP-1α [45] and inhibit OC activation by BAFF and APRIL inhibition [33].…”

Synthesis and biological evaluation of phthalimide dithiocarbamate and dithioate derivatives as anti-proliferative and anti-angiogenic agents-I

“…Based on these results and assumption, new series of phthalimide derivatives were synthesized and evaluated as potential antitumor drug candidates [6,7]. Recently, our group reported the potency of the thalidomide dithiocarbamate analogs as novel antitumor derivatives [8][9][10][11][12][13][14]. On the other hand, dithiocarbamic acid esters have drawn a great attention due to their cancer chemopreventive and antitumor activities [15,16].…”

“…On the other hand, dithiocarbamic acid esters have drawn a great attention due to their cancer chemopreventive and antitumor activities [15,16]. Some molecules that incorporated dithiocarbamic acid ester functionality, as a linker between different pharmacophores, showed significant anticancer activities, such as TH derivatives [8][9][10][11][12][13][14], chromones [17], quinazolinones [18] and naphthalimide derivatives [19].…”

“…Our research interest is still existing in development of TH analogs and potential antitumor compounds [8][9][10][11][12][13][14][20][21][22]. So, we herein describe the design, synthesis and biological evaluation of novel dithiocarbamate analogs connected either through methylene or ethylene bridges to phthalimide pharmacophoric core.…”

Synthesis, Biological Evaluation, Docking and QSAR Studies of Some Novel Naphthalimide Dithiocarbamate Analogs as Antitumor and Anti- Inflammatory Agents

“…Dithiocarbamates have been attracting considerable interest because of their diverse activities [21][22][23][24] and in the treatment of cancer [25,26]. Our group recently reported the synthesis of a novel thalidomide-containing dithiocarbamate moiety; several derivatives exhibited potent anti-cancer activity [27,28]. Based on the research for potential antitumor agents, the introduction of alkylamino groups into some pharmacophores can enhance their antitumor activity [29].…”