Effect of thalidomide and arsenic trioxide on the release of tumor necrosis factor-α and vascular endothelial growth factor from the KG-1a human acute myelogenous leukemia cell line

Girgis, Erian; Mahoney, John P.; Khalil, Rafaat; Soliman, Magdi R.I.

doi:10.3892/ol_00000116

Cited by 3 publications

(3 citation statements)

References 23 publications

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“…This mechanism seems to be important in AML biology. VEGF secretion by AML cells was confirmed in adults as for pediatric AML patients [10][11][12] . In a pediatric model, significant increase in VEGF secretion for M4/M5 AML according to the FAB classification was found.…”

Section: Cadherinsmentioning

confidence: 99%

The role of adhesion molecules in acute myeloid leukemia and (hemato)oncology: A systematic review

Kupsa¹,

Horáček²,

Jebavý³

2015

BIOMED PAP

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Background. The treatment of malignancies like acute myeloid leukemia (AML) is often complicated by the heterogeneity of the disease and the mechanisms of the disease progression. This heterogeneity is often not reflected in standard treatment approaches which provide predictable outcomes in the majority of patients but fail in individual cases even with high-dose multi-agent chemotherapy regimens and allogeneic stem cell transplantation. Further, the unselective effect of chemotherapy causes high treatment-related toxicity and accelerates the risk of infection during prolonged pancytopenia, preventing further dose escalation. Despite rapid progress in therapeutic strategies, the fatality of high-grade malignancies remains enormous. Objectives. Adhesive interactions trigger signal transduction pathway activation and this prevents the apoptosis of both normal and malignant cells. A correlation between expression of defined adhesion molecules and patient outcome has been found for several malignant diseases including AML. We aim to describe how disruption of these signalling pathways can overcome the high resistance to treatment and increase the selectivity of targeting malignant cells. This could effectively reduce the overall treatment-related toxicity and improve the general outcome. Conclusions. Adhesion molecules facilitate growth of malignant diseases. This review provides a deeper insight into these processes. Modulation of adhesion molecules-mediated interactions is an innovative and feasible approach in treatment of AML and many other malignancies. Due to expected low toxicity it is an acceptable addition to standard chemotherapeutical regimens for all age groups of patients. This approach could improve the overall treatment outcome in the future.

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Section: Cadherinsmentioning

confidence: 99%

The role of adhesion molecules in acute myeloid leukemia and (hemato)oncology: A systematic review

Kupsa¹,

Horáček²,

Jebavý³

2015

BIOMED PAP

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“…MCP-1 was moderately negatively correlated with E-selectin (r = -0.53) and positively correlated with IFN-γ (r = 0.50), corrected P = 0.0119 and P = 0.0386 respectively. The levels of EGF and VEGF correlated 1.0000 1.0000 1.0000 1.0000 1.0000 0.1709 0.5601 1.0000 1.0000 1.0000 1.0000 1.0000 1.0000 1.0000 1.0000 1.0000 1.0000 1.0000 1.0000 1.0000 IL- 4 1.0000 1.0000 1.0000 1.0000 1.0000 0.0609 1.0000 1.0000 1.0000 1.0000 1.0000 1.0000 1.0000 1.0000 1.0000 1.0000 1.0000 1.0000 1.0000 1.0000 IL- 6 1.0000 1.0000 1.0000 1.0000 1.0000 1.0000 1.0000 1.0000 1.0000 1.0000 1.0000 1.0000 1.0000 1.0000 1.0000 1.0000 1.0000 1.0000 1.0000 0.0000 VEGF 1.0000 1.0000 1.0000 1.0000 1.0000 1.0000 1.0000 1.0000 0.0020 1.0000 1.0000 1.0000 0.6044 1.0000 0.3800 1.0000 1.0000 1.0000 1.0000 1.0000 INF-G 1.0000 1.0000 1.0000 1.0000…”

Section: Cytokines and Soluble Adhesion Molecules Levelsunclassified

“…Tumor necrosis factor alpha (TNF-α) and other cytokines are involved in the pathogenesis of acute myeloid leukemia (AML) and high-risk myelodysplastic syndromes (MDS). TNF-α secretion by AML cells and its´ involvement in the activation of signal transduction pathways and disease progression have been reported 4,5 . In a prospective study on newly diagnosed AML patients, lower TNF-α levels were associated with higher rates of complete remission and better event-free survival (EFS) in univariate analyses.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of cytokines and soluble adhesion molecules in patients with newly diagnosed acute myeloid leukemia: the role of TNF-alpha and FLT3-ITD

Kupsa¹,

Vaněk²,

Vašatová³

et al. 2016

BIOMED PAP

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Objectives. Acute myeloid leukemia (AML) cells are highly resistant to therapy. The presumed molecular basis of this resistance is the effect of tumor necrosis factor alpha (TNF-α) and other cytokines on endothelial adhesion molecule expression. The aim of this study was to test the hypothesis that cytokines and soluble adhesion molecules correlate in AML. Methods. Baseline serum levels of 17 cytokines and 5 soluble adhesion molecules were measured in 53 AML patients using biochip array technology. Age, leukocyte count, secondary AML, CRP, FLT3-ITD and remission were variables. Statistical analysis was performed in R version 3.1.2. Results. VCAM-1 correlated with ICAM-1 (P < 0.0001), E-selectin (P < 0.0001), leukocyte count (P = 0.0005) and TNF-α (P = 0.0035). E-selectin correlated with leukocyte count (P < 0.0001), P-selectin (P = 0.0032) and MCP-1 (P = 0.0119). CRP correlated with IL-6 (P < 0.0001), leukocyte count negatively correlated with IL-7 (P = 0.0318). FLT3-ITD was associated with higher E-selectin (P = 0.0010) and lower IL-7 (P = 0.0252). Secondary AML patients were older. Failure of induction therapy was associated with significantly higher CRP and lower P-selectin. Leukocyte count (P < 0.0001), FLT3-ITD (P = 0.0017) and secondary AML (P = 0.0439) influenced the principal component. Conclusions. Leukemic cells can modulate the microenvironment. Cytokine, adhesion molecule levels and leukocyte count correlate in AML. Understanding these mechanisms may form the basis of novel therapeutic approaches.

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Effects of thalidomide on growth and VEGF-A expression in SW480 colon cancer cells

Zhang

Luo

2017

Oncol Lett

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Abstract. Lymphatic and hematogenous spread are the most common ways for tumors to metastasize. Angiogenesis is essential for tumor growth and metastasis. Vascular endothelial growth factor (VEGF) particularly VEGF-A is important in the process of angiogenesis. The current research has indicated that thalidomide (THD) may be able to inhibit angiogenesis, stimulate the activity of the immune system and inhibit the adherence of cancer cells to stromal cells. These changes may lead to suppression of tumor occurrence and development. To date, to the best of our knowledge, the effects of THD on colon cancer SW480 cells have not been reported. In the present study, the effects of THD and a combination of THD and oxaliplatin (L-OHP) on the proliferation of SW480 cells have been investigated. Furthermore, the expression of VEGF-A and hypoxia-inducible factor 1 (HIF-1) was analyzed using MTT assay, quantitative polymerase chain reaction and western blot analysis. The results indicated that THD was able to inhibit SW480 cells in dose-and-time dependent manner and inhibit the expression of VEGF-A and HIF-1α. Furthermore, treatment with THD and L-OHP had synergistic inhibitory effect, which may provide a novel treatment strategy for advanced colorectal cancer.

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Effect of thalidomide and arsenic trioxide on the release of tumor necrosis factor-α and vascular endothelial growth factor from the KG-1a human acute myelogenous leukemia cell line

Cited by 3 publications

References 23 publications

The role of adhesion molecules in acute myeloid leukemia and (hemato)oncology: A systematic review

The role of adhesion molecules in acute myeloid leukemia and (hemato)oncology: A systematic review

Evaluation of cytokines and soluble adhesion molecules in patients with newly diagnosed acute myeloid leukemia: the role of TNF-alpha and FLT3-ITD

Effects of thalidomide on growth and VEGF-A expression in SW480 colon cancer cells

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