Effect of Texture on the Rate of Hydroxyapatite Formation on Gel‐Silica Surface

Pereira, Marivalda M.; Clark, A. E.; Hench, Larry L.

doi:10.1111/j.1151-2916.1995.tb08686.x

Cited by 239 publications

(161 citation statements)

References 26 publications

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“…The results from ICP analysis showed the considerable reduction of phosphate concentration after 24 h and the increase of Ca concentration which are markers for HCA layer precipitation. Indeed, the high-surface area and CaO content of BG nanopowders and its fast dissolution kinetics prepared the ideal conditions for HCA layer formation on the BG nanopowders [6,[28][29][30][31][32]. Balamurugan et al evaluated in-vitro antibacterial activity of silver-incorporated bioglass (AGBG) in comparison with the ternary sol-gel glass (BG) on Escherichia coli bacterium.…”

Section: Discussionmentioning

confidence: 99%

Copper-doped and copper-free bioactive glass nanopowders cytotoxicity and antibacterial activity assessment

Soltani-Dehnavi

Mehdikhani-Nahrkhalaji

Rafienia

et al. 2017

Scientia Iranica

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Abstract. The purpose of this study is to evaluate the antibacterial activity and cytotoxicity of copper-doped (Cu45SBG) and copper-free bioactive glass (45SBG) nanopowders. The antibacterial e ect was studied using Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) bacteria. The BG nanopowders were synthesized by the sol-gel technique. They were characterized by various techniques and their cytotoxicity was evaluated by MTT assay. Chemical compositions of BGs were as the same as the predicted compositions. The size of the BGs with an amorphous structure was measured to be around 100 nm. Both BG nanopowders have no antibacterial e ect on broth concentrations less than 12.5 mg/ml. They demonstrated similar antibacterial activity on E. coli with Minimum Bactericidal Concentration (MBC) of 12.5 mg/ml. Cu45SBG nanopowders with the MBC of 25 mg/ml were more e cient on S. aureous bacteria than 45SBG nanopowders with the MBC of 50 mg/ml. Compared to 45SBG, Cu45SBG showed much more cytotoxicity. 45SBG demonstrated similar cells viability to the control. It was concluded that to overcome cytotoxic e ect, Cu content of BGs nanopowders must be lower than the amount used in this research. Therefore, 45SBG nanopowders with considerable antibacterial activity could be used as a good candidate for biomedical applications.

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Section: Discussionmentioning

confidence: 99%

Copper-doped and copper-free bioactive glass nanopowders cytotoxicity and antibacterial activity assessment

Soltani-Dehnavi

Mehdikhani-Nahrkhalaji

Rafienia

et al. 2017

Scientia Iranica

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“…Sol-gel derived bioactive glasses can be produced at low temperatures and formed into monolithic scaffolds in situ by direct foaming [24][25][26][27], freeze-casting [28][29][30], and even fibrous structures via electrospinning and air-spraying (a process analogous to SBS) [31,32]. Notably, bioactive glasses with compositions that contain calcium and phosphate exhibit more bioactivity than pure silica based glasses [33,34]. However, these materials can be brittle and it can be challenging to incorporate therapeutic ions into the glass network, especially when low/non-toxic materials are desired [35,36].…”

Section: Introductionmentioning

confidence: 99%

Hybrid sol–gel inorganic/gelatin porous fibres via solution blow spinning

et al. 2017

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Hybrid sol-gel inorganic-organic fibres offer great potential in tissue engineering and regenerative medicine. A significant challenge is to process them using scalable technologies into useful scaffolds that provide control over fibre diameter, morphology, mechanical properties, ion release, degradation and cell response. In this work we develop formulations that are amenable to processing via solution blow spinning (SBS), a rapid technique using simple equipment to spray nano-/ micro-fibres without any electric fields. The technique is extended to produce porous class I and II hybrid fibres using cryogenic SBS, with formulations developed based on tetraethyl orthosilicate/gelatin that are relatively facile to lyophilise. The formulations developed here take advantage of the reversible thermally activated conformation change of gelatin in aqueous solutions from random coil to triple helix to enable viscosity tuning and therefore fibre spinning. Gelatin is functionalised with (3-glycidyloxypropyl)trimethoxysilane to produce class II hybrids which exhibit controllable time-and temperature-dependent viscosity profiles which can be tuned for spinning into highly porous fibres.Ryan D. Greenhalgh and William S. Ambler are joint first authors due to equal contribution.

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“…[13][14][15] This behaviour is considered an indication of in vivo bioactivity. [16][17][18] The sol-gel method has been proposed as a suitable procedure to produce protective [19][20][21] and bioactive 22,23 coatings. The advantages and technological significance of these sol-gel coatings over those produced by other methods have been widely demonstrated.…”

Section: Introductionmentioning

confidence: 99%

Sol–gel coatings for protection and bioactivation of metals used in orthopaedic devices

et al. 2004

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The aim of this work is the production and characterisation of sol-gel coatings for protection and bioactivation of metals used as standard surgical implant materials, such as stainless steel 316 L (ASTM F138), Co based alloys (ASTM F75) and titanium alloy Ti-6Al-4V (ASTM F67). These films should both prevent degradation of the substrates by wear or corrosion, and bioactivate the material for inducing the formation of a hydroxyapatite (HA) rich layer onto the material surface, thereby permitting a natural bonding to living tissues. Formation of HA layers can be observed on performing in vitro tests by soaking the material in simulated body solutions. The work describes the development of coatings containing bioactive glass and glass-ceramic particles in hybrid methyl-triethoxysilane (MTES) and tetraethylorthosilicate (TEOS) acidic sol, applied by dip-coating to surgical alloys, AISI 316 L, ASTM F75 and ASTM 67, with the aim of accomplishing both high corrosion resistance of the metal in the body environment and adhesion of the implant to the surrounding tissue. The performance of the coated metal was evaluated in vitro by electrochemical techniques including potentiodynamic polarisation curves and electrochemical impedance spectroscopy, to follow the formation of hydroxyapatite on the surface, as well as the in vitro release of ions by plasma atomic emission spectroscopy (ICP-MS) after up to one year of immersion. In vivo behaviour was evaluated by subcutaneous tests and endomedullar implantation in Hokaido rats to study possible rejection reactions and natural bonding to living tissue.

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Effect of Texture on the Rate of Hydroxyapatite Formation on Gel‐Silica Surface

Cited by 239 publications

References 26 publications

Copper-doped and copper-free bioactive glass nanopowders cytotoxicity and antibacterial activity assessment

Copper-doped and copper-free bioactive glass nanopowders cytotoxicity and antibacterial activity assessment

Hybrid sol–gel inorganic/gelatin porous fibres via solution blow spinning

Sol–gel coatings for protection and bioactivation of metals used in orthopaedic devices

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