Effect of Text Messaging Plus Peer Navigation on Viral Suppression Among Youth With HIV in the iCARE Nigeria Pilot Study

Taiwo, Babafemi; Kuti, Kehinde M.; Kuhns, Lisa M.; Omigbodun, Olayinka; Awolude, Olutosin; Adetunji, A.; Berzins, Baiba; Janulis, Patrick; Johnson, Amy K.; Okonkwor, Ogochukwu; Oladeji, Bibilola D.; Muldoon, Abigail L.; Adewumi, Olubusuyi M; Amoo, Paul; Atunde, Hannah; Kapogiannis, Bill G.; Garofalo, Robert

doi:10.1097/qai.0000000000002694

Cited by 13 publications

(10 citation statements)

References 40 publications

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“…This study makes a unique contribution to the literature on adherence among YLH. Compared with prior studies, [44][45][46] self-reported medication adherence was highly related to viral load and was about 10% higher than previous reports. About 79% of participants who self-reported adherence were suppressed compared with 61% of those who reported nonadherence were virally suppressed.…”

Section: Discussioncontrasting

confidence: 82%

Factors Associated With Antiretroviral Adherence Among Youth Living With HIV

Arnold,

Kamal,

Rotheram-Borus

et al. 2024

JAIDS Journal of Acquired Immune Deficiency Syndromes

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Background: Youth living with HIV (YLH) have an increased risk for psychosocial stressors that can impact their antiretroviral (ARV) adherence. We examined factors associated with self-reported ARV adherence among YLH ages 12-24 years old. Setting: YLH (N=147) were recruited in Los Angeles, California, and New Orleans, Louisiana from 2017-2020. Methods: YLH whose self-reported recent (30 days) ARV adherence was “excellent” or “very good” were compared to non-adherent YLH on sociodemographic, clinical, and psychosocial factors using both univariate and multivariate analyses. Results: Participants were predominantly male (88%), and 81% identified as gay, bisexual, transgender, queer, or other. The mean duration on ARV was 27 months (range: 0-237 months). Most YLH (71.2%) self-reported being adherent, and 79% of those who self-reported adherence were also virally suppressed (<200 copies/mL). Multivariate analysis indicated being adherent was significantly associated with white race [aOR=8.07, (CI=1.45, 74.0)], Hispanic/Latinx ethnicity [aOR=3.57, CI=(1.16, 12.80)], more social support [aOR=1.11, (CI=1.05, 1.18)], and being on ARV for a shorter duration [aOR=0.99, (CI=0.97, 0.99)]. Mental health symptoms, substance use, age, and history of homelessness or incarceration were unrelated to adherence. Conclusions: Enhancing efforts to provide support for adherence to non-white youth, as well as those with limited social support and who have been on ARV treatment longer, may help increase viral suppression among YHL.

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Section: Discussioncontrasting

confidence: 82%

Factors Associated With Antiretroviral Adherence Among Youth Living With HIV

Arnold,

Kamal,

Rotheram-Borus

et al. 2024

JAIDS Journal of Acquired Immune Deficiency Syndromes

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“…Table 1 outlines the characteristics of the eight studies [22][23][24][25][26][27][28][29][30][31][32][33][34][35]. All studies proposed pilot and preparatory research during the initial 2 years, followed by a randomized controlled trial in the subsequent 3 years of the project.…”

Section: Resultsmentioning

confidence: 99%

Accelerating adolescent HIV research in low-income and middle-income countries: evidence from a research consortium

Tucker

Iwelunmor

Abrams

et al. 2021

Aids

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Objective: Many adolescents and young adults (AYA) have unmet HIV prevention needs. We describe the Prevention and Treatment through a Comprehensive Care Continuum for HIV-affected Adolescents in Resource Constrained Settings (PATC 3 H) consortium organization, transition milestones, and youth engagement strategies. The PATC 3 H consortium focuses on reducing HIV incidence and related health disparities among AYA.Design and Methods: Organizational data were obtained from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) and supplemented with a brief survey completed by study principal investigators. Transition from the initial phase (years 1 and 2) to the subsequent phase (years 3 and 5) was contingent on meeting prespecified milestones. We reviewed the structure and function of the research consortium, identified shared elements of transition milestones, and examined common youth engagement strategies. Results:The PATC 3 H consortium supports eight research studies through a milestone transition mechanism. The consortium includes AYA HIV research studies in seven

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“…Although there is sufficient literature confirming that mobile and electronic health interventions for ALHIV are feasible and acceptable [42][43][44][45], evidence regarding the efficacy and effectiveness of these interventions in SSA is lacking. The few randomized controlled trials available display minimal and/or mixed effects regarding the efficacy of mHealth interventions for ALHIV in SSA [46][47][48], with only a few demonstrating promising effects [49,50].…”

Section: Perceived Individual-level Impactsmentioning

confidence: 99%

Impact of COVID-19 on Adolescent HIV Prevention and Treatment Services in the AHISA Network

et al. 2022

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We investigated perceived impacts of COVID-19 on the delivery of adolescent HIV treatment and prevention services in sub-Saharan Africa (SSA) by administering a survey to members of the Adolescent HIV Prevention and Treatment Implementation Science Alliance (AHISA) from February to April 2021. We organized COVID-19 impacts, as perceived by AHISA teams, under three themes: service interruptions, service adjustments, and perceived individual-level health impacts. AHISA teams commonly reported interruptions to prevention programs, diagnostic testing, and access to antiretroviral therapy (ART). Common service adjustments included decentralization of ART refills, expanded multi-month ART distribution, and digital technology use. Perceived individual-level impacts included social isolation, loss to follow-up, food insecurity, poverty, and increases in adolescent pregnancies and sexually transmitted infections. The need for collaboration among stakeholders were commonly cited as lessons learned by AHISA teams. Survey findings highlight the need for implementation science research to evaluate the effects of pandemic-related HIV service adaptations in SSA.

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Effect of Text Messaging Plus Peer Navigation on Viral Suppression Among Youth With HIV in the iCARE Nigeria Pilot Study

Abstract: Supplemental Digital Content is Available in the Text.

Cited by 13 publications

References 40 publications

Factors Associated With Antiretroviral Adherence Among Youth Living With HIV

Factors Associated With Antiretroviral Adherence Among Youth Living With HIV

Accelerating adolescent HIV research in low-income and middle-income countries: evidence from a research consortium

Impact of COVID-19 on Adolescent HIV Prevention and Treatment Services in the AHISA Network

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